Whole Brain Radiotherapy Combined with Simultaneous Integrated Boost for Brain Metastases of Lung Cancer: Its Clinical Effectiveness and Prognosis
Objective To investigate the shorter-term curative efficacy and safety of whole brain radio therapy(WBRT) combined with simultaneous integrated boost versus sequential integrated boost using image-guided intensity-modulated radiotherapy (IG-IMRT) for lung cancer patients with 1-4 brain metastases, a...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | zho |
| Published: |
Magazine House of Cancer Research on Prevention and Treatment
2018-08-01
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| Series: | Zhongliu Fangzhi Yanjiu |
| Subjects: | |
| Online Access: | http://html.rhhz.net/ZLFZYJ/html/8578.2018.17.1223.htm |
| _version_ | 1818303269036883968 |
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| author | HE Jun ZHANG Chengda JIA Lin HAN Jianjun GAO Fei WANG Yun JIA Li JIA Dong CHEN Yan |
| author_facet | HE Jun ZHANG Chengda JIA Lin HAN Jianjun GAO Fei WANG Yun JIA Li JIA Dong CHEN Yan |
| author_sort | HE Jun |
| collection | DOAJ |
| description | Objective To investigate the shorter-term curative efficacy and safety of whole brain radio therapy(WBRT) combined with simultaneous integrated boost versus sequential integrated boost using image-guided intensity-modulated radiotherapy (IG-IMRT) for lung cancer patients with 1-4 brain metastases, and to confirm the optimal treatment scheme of lung cancer patients with brain metastases. Methods We analyzed retrospectively the data of 98 patients diagnosed as brain metastases from lung cancer and admitted in our hospital from May 2014 to May 2017. The patients were divided into two groups: WBRT combined with simultaneous integrated boost (observation group, n=49) or WBRT combined with sequential integrated boost (control group, n=49) using image-guided intensity-modulated radiotherapy to compare the curative efficacy and safety. In the process of treatment, cone-beam CT(CBCT) was used to correct the position. Results The total effective rate, local control rate and 1-year survival rate in the observation group were higher than those in the control group(87.80%(43/49) vs. 61.20%(30/49), 95.92%(47/49) vs. 81.60% (40/49), 65.31% (32/49) vs. 44.90% (22/49) (all P < 0.05). Median survival time in the observation group was higher than that in the control group(15 vs. 12 months). In addition, no 3-4 grades acute or late toxicities occurred. The main adverse effects included alopecia, nausea, vomiting, cognitive impairment and memory injury. Conclusion Wholebrain radiotherapy combined with simultaneous integrated boost using image-guided intensity-modulated radiotherapy is a safe and effective treatment for the lung cancer patients with brain metastases. |
| first_indexed | 2024-12-13T05:52:07Z |
| format | Article |
| id | doaj.art-77fc201418ea4ec393a9d5952af06464 |
| institution | Directory Open Access Journal |
| issn | 1000-8578 1000-8578 |
| language | zho |
| last_indexed | 2024-12-13T05:52:07Z |
| publishDate | 2018-08-01 |
| publisher | Magazine House of Cancer Research on Prevention and Treatment |
| record_format | Article |
| series | Zhongliu Fangzhi Yanjiu |
| spelling | doaj.art-77fc201418ea4ec393a9d5952af064642022-12-21T23:57:32ZzhoMagazine House of Cancer Research on Prevention and TreatmentZhongliu Fangzhi Yanjiu1000-85781000-85782018-08-0145858759210.3971/j.issn.1000-8578.2018.17.12238578.2018.17.1223Whole Brain Radiotherapy Combined with Simultaneous Integrated Boost for Brain Metastases of Lung Cancer: Its Clinical Effectiveness and PrognosisHE Jun0ZHANG Chengda1JIA Lin2HAN Jianjun3GAO Fei4WANG Yun5JIA Li6JIA Dong7CHEN Yan8Department of Oncology, The Third Hospital of Mianyang(Sichuan Mental Health Center), Mianyang 621000, ChinaDepartment of Gastroenterology, The Third Hospital of Mianyang(Sichuan Mental Health Center), Mianyang 621000, ChinaDepartment of Oncology, The Third Hospital of Mianyang(Sichuan Mental Health Center), Mianyang 621000, ChinaDepartment of Oncology, The Third Hospital of Mianyang(Sichuan Mental Health Center), Mianyang 621000, ChinaDepartment of Oncology, The Third Hospital of Mianyang(Sichuan Mental Health Center), Mianyang 621000, ChinaDepartment of Oncology, The Third Hospital of Mianyang(Sichuan Mental Health Center), Mianyang 621000, ChinaDepartment of Oncology, The Third Hospital of Mianyang(Sichuan Mental Health Center), Mianyang 621000, ChinaDepartment of Oncology, The Third Hospital of Mianyang(Sichuan Mental Health Center), Mianyang 621000, ChinaDepartment of Oncology, The Third Hospital of Mianyang(Sichuan Mental Health Center), Mianyang 621000, ChinaObjective To investigate the shorter-term curative efficacy and safety of whole brain radio therapy(WBRT) combined with simultaneous integrated boost versus sequential integrated boost using image-guided intensity-modulated radiotherapy (IG-IMRT) for lung cancer patients with 1-4 brain metastases, and to confirm the optimal treatment scheme of lung cancer patients with brain metastases. Methods We analyzed retrospectively the data of 98 patients diagnosed as brain metastases from lung cancer and admitted in our hospital from May 2014 to May 2017. The patients were divided into two groups: WBRT combined with simultaneous integrated boost (observation group, n=49) or WBRT combined with sequential integrated boost (control group, n=49) using image-guided intensity-modulated radiotherapy to compare the curative efficacy and safety. In the process of treatment, cone-beam CT(CBCT) was used to correct the position. Results The total effective rate, local control rate and 1-year survival rate in the observation group were higher than those in the control group(87.80%(43/49) vs. 61.20%(30/49), 95.92%(47/49) vs. 81.60% (40/49), 65.31% (32/49) vs. 44.90% (22/49) (all P < 0.05). Median survival time in the observation group was higher than that in the control group(15 vs. 12 months). In addition, no 3-4 grades acute or late toxicities occurred. The main adverse effects included alopecia, nausea, vomiting, cognitive impairment and memory injury. Conclusion Wholebrain radiotherapy combined with simultaneous integrated boost using image-guided intensity-modulated radiotherapy is a safe and effective treatment for the lung cancer patients with brain metastases.http://html.rhhz.net/ZLFZYJ/html/8578.2018.17.1223.htmlung cancerbrain metastasiswholebrain radiotherapysimultaneous integrated boosthypofractionated |
| spellingShingle | HE Jun ZHANG Chengda JIA Lin HAN Jianjun GAO Fei WANG Yun JIA Li JIA Dong CHEN Yan Whole Brain Radiotherapy Combined with Simultaneous Integrated Boost for Brain Metastases of Lung Cancer: Its Clinical Effectiveness and Prognosis Zhongliu Fangzhi Yanjiu lung cancer brain metastasis wholebrain radiotherapy simultaneous integrated boost hypofractionated |
| title | Whole Brain Radiotherapy Combined with Simultaneous Integrated Boost for Brain Metastases of Lung Cancer: Its Clinical Effectiveness and Prognosis |
| title_full | Whole Brain Radiotherapy Combined with Simultaneous Integrated Boost for Brain Metastases of Lung Cancer: Its Clinical Effectiveness and Prognosis |
| title_fullStr | Whole Brain Radiotherapy Combined with Simultaneous Integrated Boost for Brain Metastases of Lung Cancer: Its Clinical Effectiveness and Prognosis |
| title_full_unstemmed | Whole Brain Radiotherapy Combined with Simultaneous Integrated Boost for Brain Metastases of Lung Cancer: Its Clinical Effectiveness and Prognosis |
| title_short | Whole Brain Radiotherapy Combined with Simultaneous Integrated Boost for Brain Metastases of Lung Cancer: Its Clinical Effectiveness and Prognosis |
| title_sort | whole brain radiotherapy combined with simultaneous integrated boost for brain metastases of lung cancer its clinical effectiveness and prognosis |
| topic | lung cancer brain metastasis wholebrain radiotherapy simultaneous integrated boost hypofractionated |
| url | http://html.rhhz.net/ZLFZYJ/html/8578.2018.17.1223.htm |
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