New 3′,8′′-Linked Biflavonoids from Selaginella uncinata Displaying Protective Effect against Anoxia
Seven 3′,8′′-linked bioflavonoids, including one new compound, (2′′S)-2′′, 3′′-dihydroamentoflavone-4′-methyl ether (1) and six known compounds: (2S)-2,3- dihydroamentoflavone-4′-methyl ether (2), (2S,2′′S)-2,3,2′′,3′′-tetrahydroamento- flavone-4′-methyl ether (3), (2S,2′′S)-tetrahydroamentoflavone...
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| Format: | Article |
| Language: | English |
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MDPI AG
2011-07-01
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| Series: | Molecules |
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| Online Access: | http://www.mdpi.com/1420-3049/16/8/6206/ |
| _version_ | 1818345057720205312 |
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| author | Ming Fan Zhi-Yun Du Kun Zhang Ming-Ming Li Li-Ying Wu Yan-Xiong Fang Nai-Li Wang Hui Zhi Yi Dai Jun-Xia Zheng Yang Zheng |
| author_facet | Ming Fan Zhi-Yun Du Kun Zhang Ming-Ming Li Li-Ying Wu Yan-Xiong Fang Nai-Li Wang Hui Zhi Yi Dai Jun-Xia Zheng Yang Zheng |
| author_sort | Ming Fan |
| collection | DOAJ |
| description | Seven 3′,8′′-linked bioflavonoids, including one new compound, (2′′S)-2′′, 3′′-dihydroamentoflavone-4′-methyl ether (1) and six known compounds: (2S)-2,3- dihydroamentoflavone-4′-methyl ether (2), (2S,2′′S)-2,3,2′′,3′′-tetrahydroamento- flavone-4′-methyl ether (3), (2S,2′′S)-tetrahydroamentoflavone (4), (2S)-2,3-dihydro- amentoflavone (5) and (2′′S)-2′′,3′′-dihydroamentoflavone (6) and amentoflavone (7), were isolated from the 60% ethanolic extract of Selaginella uncinata (Desv.) Spring. The structures of these compounds were elucidated mainly by analysis of their 1D and 2D NMR spectroscopic data, and their absolute configurations were determined by circular-dichroism (CD) spectroscopy. All the seven compounds showed protective effect against anoxia in the anoxic PC12 cells assay, in which compound 6 displayed particularly potent activity. |
| first_indexed | 2024-12-13T16:56:19Z |
| format | Article |
| id | doaj.art-77fc226bf47e4f91b5a677f24c537712 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-13T16:56:19Z |
| publishDate | 2011-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-77fc226bf47e4f91b5a677f24c5377122022-12-21T23:37:55ZengMDPI AGMolecules1420-30492011-07-011686206621410.3390/molecules16086206New 3′,8′′-Linked Biflavonoids from Selaginella uncinata Displaying Protective Effect against AnoxiaMing FanZhi-Yun DuKun ZhangMing-Ming LiLi-Ying WuYan-Xiong FangNai-Li WangHui ZhiYi DaiJun-Xia ZhengYang ZhengSeven 3′,8′′-linked bioflavonoids, including one new compound, (2′′S)-2′′, 3′′-dihydroamentoflavone-4′-methyl ether (1) and six known compounds: (2S)-2,3- dihydroamentoflavone-4′-methyl ether (2), (2S,2′′S)-2,3,2′′,3′′-tetrahydroamento- flavone-4′-methyl ether (3), (2S,2′′S)-tetrahydroamentoflavone (4), (2S)-2,3-dihydro- amentoflavone (5) and (2′′S)-2′′,3′′-dihydroamentoflavone (6) and amentoflavone (7), were isolated from the 60% ethanolic extract of Selaginella uncinata (Desv.) Spring. The structures of these compounds were elucidated mainly by analysis of their 1D and 2D NMR spectroscopic data, and their absolute configurations were determined by circular-dichroism (CD) spectroscopy. All the seven compounds showed protective effect against anoxia in the anoxic PC12 cells assay, in which compound 6 displayed particularly potent activity.http://www.mdpi.com/1420-3049/16/8/6206/Selaginella uncinata (Desv.) Spring3′,8′′-linked biflavonoidsprotective effect against anoxia(2′′S) 2′′,3′′-dihydroamentoflavone-4′-methyl ether |
| spellingShingle | Ming Fan Zhi-Yun Du Kun Zhang Ming-Ming Li Li-Ying Wu Yan-Xiong Fang Nai-Li Wang Hui Zhi Yi Dai Jun-Xia Zheng Yang Zheng New 3′,8′′-Linked Biflavonoids from Selaginella uncinata Displaying Protective Effect against Anoxia Molecules Selaginella uncinata (Desv.) Spring 3′,8′′-linked biflavonoids protective effect against anoxia (2′′S) 2′′,3′′-dihydroamentoflavone-4′-methyl ether |
| title | New 3′,8′′-Linked Biflavonoids from Selaginella uncinata Displaying Protective Effect against Anoxia |
| title_full | New 3′,8′′-Linked Biflavonoids from Selaginella uncinata Displaying Protective Effect against Anoxia |
| title_fullStr | New 3′,8′′-Linked Biflavonoids from Selaginella uncinata Displaying Protective Effect against Anoxia |
| title_full_unstemmed | New 3′,8′′-Linked Biflavonoids from Selaginella uncinata Displaying Protective Effect against Anoxia |
| title_short | New 3′,8′′-Linked Biflavonoids from Selaginella uncinata Displaying Protective Effect against Anoxia |
| title_sort | new 3 8 linked biflavonoids from selaginella uncinata displaying protective effect against anoxia |
| topic | Selaginella uncinata (Desv.) Spring 3′,8′′-linked biflavonoids protective effect against anoxia (2′′S) 2′′,3′′-dihydroamentoflavone-4′-methyl ether |
| url | http://www.mdpi.com/1420-3049/16/8/6206/ |
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