Ethyl pyruvate protects against hypoxic-ischemic brain injury via anti-cell death and anti-inflammatory mechanisms

Ethyl pyruvate protects against hypoxic-ischemic brain injury via anti-cell death and anti-inflammatory mechanisms

Ethyl pyruvate (EP) is protective in experimental models of many illnesses. This study investigates whether EP can protect against neonatal hypoxic-ischemic (H-I) brain injury. Pre-treatment with EP significantly reduced brain damage at 7 days post-H-I, with 50 mg/kg EP achieving over 50% recovery i...

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Bibliographic Details
Main Authors: Hongxia Shen, Xiaoming Hu, Can Liu, Suping Wang, Wenting Zhang, Hui Gao, R. Anne Stetler, Yanqin Gao, Jun Chen
Format: Article
Language:English
Published: Elsevier 2010-03-01
Series:Neurobiology of Disease
Subjects:
Neonatal hypoxia-ischemia
Neuroprotection
Cell death
Inflammation
Microglia
Calpain
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996109003659

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