Enhanced MRI T 2 Relaxivity in Contrast-Probed Anchor-Free PEGylated Iron Oxide Nanoparticles
Abstract Superparamagnetic iron oxide nanoparticles (SPIONs, ~11-nm cores) were PEGylated without anchoring groups and studied as efficient MRI T 2 contrast agents (CAs). The ether group of PEG is efficiently and directly linked to the positively charged surface of SPIONs, and mediated through a dip...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2017-04-01
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| Series: | Nanoscale Research Letters |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s11671-017-2084-y |
| _version_ | 1827886322938806272 |
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| author | Bibek Thapa Daysi Diaz-Diestra Juan Beltran-Huarac Brad R. Weiner Gerardo Morell |
| author_facet | Bibek Thapa Daysi Diaz-Diestra Juan Beltran-Huarac Brad R. Weiner Gerardo Morell |
| author_sort | Bibek Thapa |
| collection | DOAJ |
| description | Abstract Superparamagnetic iron oxide nanoparticles (SPIONs, ~11-nm cores) were PEGylated without anchoring groups and studied as efficient MRI T 2 contrast agents (CAs). The ether group of PEG is efficiently and directly linked to the positively charged surface of SPIONs, and mediated through a dipole-cation covalent interaction. Anchor-free PEG-SPIONs exhibit a spin-spin relaxivity of 123 ± 6 mM−1s−1, which is higher than those of PEG-SPIONs anchored with intermediate biomolecules, iron oxide nanoworms, or Feridex. They do not induce a toxic response for Fe concentrations below 2.5 mM, as tested on four different cell lines with and without an external magnetic field. Magnetic resonance phantom imaging studies show that anchor-free PEG-SPIONs produce a significant contrast in the range of 0.1–0.4 [Fe] mM. Our findings reveal that the PEG molecules attached to the cores immobilize water molecules in large regions of ~85 nm, which would lead to blood half-life of a few tens of minutes. This piece of research represents a step forward in the development of next-generation CAs for nascent-stage cancer detection. Graphical Abstract Contrast-probed anchor-free PEGylated iron oxide contrast agent |
| first_indexed | 2024-03-12T20:00:53Z |
| format | Article |
| id | doaj.art-77fd7fa4699d43f6906b0a282f0799f6 |
| institution | Directory Open Access Journal |
| issn | 1931-7573 1556-276X |
| language | English |
| last_indexed | 2024-03-12T20:00:53Z |
| publishDate | 2017-04-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Nanoscale Research Letters |
| spelling | doaj.art-77fd7fa4699d43f6906b0a282f0799f62023-08-02T02:25:14ZengSpringerOpenNanoscale Research Letters1931-75731556-276X2017-04-0112111310.1186/s11671-017-2084-yEnhanced MRI T 2 Relaxivity in Contrast-Probed Anchor-Free PEGylated Iron Oxide NanoparticlesBibek Thapa0Daysi Diaz-Diestra1Juan Beltran-Huarac2Brad R. Weiner3Gerardo Morell4Department of Physics, University of Puerto RicoMolecular Sciences Research Center, University of Puerto RicoDepartment of Physics, University of Puerto RicoMolecular Sciences Research Center, University of Puerto RicoDepartment of Physics, University of Puerto RicoAbstract Superparamagnetic iron oxide nanoparticles (SPIONs, ~11-nm cores) were PEGylated without anchoring groups and studied as efficient MRI T 2 contrast agents (CAs). The ether group of PEG is efficiently and directly linked to the positively charged surface of SPIONs, and mediated through a dipole-cation covalent interaction. Anchor-free PEG-SPIONs exhibit a spin-spin relaxivity of 123 ± 6 mM−1s−1, which is higher than those of PEG-SPIONs anchored with intermediate biomolecules, iron oxide nanoworms, or Feridex. They do not induce a toxic response for Fe concentrations below 2.5 mM, as tested on four different cell lines with and without an external magnetic field. Magnetic resonance phantom imaging studies show that anchor-free PEG-SPIONs produce a significant contrast in the range of 0.1–0.4 [Fe] mM. Our findings reveal that the PEG molecules attached to the cores immobilize water molecules in large regions of ~85 nm, which would lead to blood half-life of a few tens of minutes. This piece of research represents a step forward in the development of next-generation CAs for nascent-stage cancer detection. Graphical Abstract Contrast-probed anchor-free PEGylated iron oxide contrast agenthttp://link.springer.com/article/10.1186/s11671-017-2084-yPEGylationMagnetic iron oxide nanopaticlesT 2 relaxivityMRI contrast agents |
| spellingShingle | Bibek Thapa Daysi Diaz-Diestra Juan Beltran-Huarac Brad R. Weiner Gerardo Morell Enhanced MRI T 2 Relaxivity in Contrast-Probed Anchor-Free PEGylated Iron Oxide Nanoparticles Nanoscale Research Letters PEGylation Magnetic iron oxide nanopaticles T 2 relaxivity MRI contrast agents |
| title | Enhanced MRI T 2 Relaxivity in Contrast-Probed Anchor-Free PEGylated Iron Oxide Nanoparticles |
| title_full | Enhanced MRI T 2 Relaxivity in Contrast-Probed Anchor-Free PEGylated Iron Oxide Nanoparticles |
| title_fullStr | Enhanced MRI T 2 Relaxivity in Contrast-Probed Anchor-Free PEGylated Iron Oxide Nanoparticles |
| title_full_unstemmed | Enhanced MRI T 2 Relaxivity in Contrast-Probed Anchor-Free PEGylated Iron Oxide Nanoparticles |
| title_short | Enhanced MRI T 2 Relaxivity in Contrast-Probed Anchor-Free PEGylated Iron Oxide Nanoparticles |
| title_sort | enhanced mri t 2 relaxivity in contrast probed anchor free pegylated iron oxide nanoparticles |
| topic | PEGylation Magnetic iron oxide nanopaticles T 2 relaxivity MRI contrast agents |
| url | http://link.springer.com/article/10.1186/s11671-017-2084-y |
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