Dynapenic Obesity and Prevalence of Type 2 Diabetes in Middle-Aged Japanese Men
Background: The independent and combined associations of muscle strength and obesity on the prevalence of type 2 diabetes in Japanese men remain unclear. Methods: Hand grip strength was cross-sectionally evaluated between 2011 and 2013 to assess muscle strength in 5039 male workers aged 40 to 64 ye...
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| Format: | Article |
| Language: | English |
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Japan Epidemiological Association
2015-11-01
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| Series: | Journal of Epidemiology |
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| Online Access: | https://www.jstage.jst.go.jp/article/jea/25/10/25_JE20140256/_pdf |
| _version_ | 1818750116318674944 |
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| author | Ryoko Kawakami |
| author_facet | Ryoko Kawakami |
| author_sort | Ryoko Kawakami |
| collection | DOAJ |
| description | Background: The independent and combined associations of muscle strength and obesity on the prevalence of type 2 diabetes in Japanese men remain unclear.
Methods: Hand grip strength was cross-sectionally evaluated between 2011 and 2013 to assess muscle strength in 5039 male workers aged 40 to 64 years. Weight and height were measured, and overweight/obesity was defined as a body mass index ≥25 kg/m2. The prevalence of type 2 diabetes, defined as fasting plasma glucose ≥126 mg/dL and/or hemoglobin A1c ≥6.5% and/or self-reported physician-diagnosed diabetes, was evaluated. Odds ratios (OR) and 95% confidence intervals (95% CI) for the prevalence of type 2 diabetes were obtained using a logistic regression model.
Results: In total, 611 participants had type 2 diabetes, and 1763 participants were overweight/obese. After adjustment for covariates, we found an inverse association between muscle strength and the prevalence of type 2 diabetes (P for trend <0.01). In addition, when the analyses were stratified by obesity status, the multivariable-adjusted OR per 2-standard-deviation increase in muscle strength was 0.64 (95% CI, 0.49–0.83) in the overweight/obese group, compared to a weaker relationship in the normal-weight group (OR 0.79 per 2-standard-deviation increase; 95% CI, 0.60–1.06).
Conclusions: Dynapenia, an age-related decrease in muscle strength, is associated with increased prevalence of type 2 diabetes, and this relationship is stronger in overweight/obese middle-aged Japanese men than in normal-weight men. |
| first_indexed | 2024-12-18T04:14:33Z |
| format | Article |
| id | doaj.art-77fe33f4bda64e109379f12b283d4f62 |
| institution | Directory Open Access Journal |
| issn | 0917-5040 1349-9092 |
| language | English |
| last_indexed | 2024-12-18T04:14:33Z |
| publishDate | 2015-11-01 |
| publisher | Japan Epidemiological Association |
| record_format | Article |
| series | Journal of Epidemiology |
| spelling | doaj.art-77fe33f4bda64e109379f12b283d4f622022-12-21T21:21:23ZengJapan Epidemiological AssociationJournal of Epidemiology0917-50401349-90922015-11-01251065666210.2188/jea.JE20140256Dynapenic Obesity and Prevalence of Type 2 Diabetes in Middle-Aged Japanese MenRyoko Kawakami0Graduate School of Sport Sciences, Waseda UniversityBackground: The independent and combined associations of muscle strength and obesity on the prevalence of type 2 diabetes in Japanese men remain unclear. Methods: Hand grip strength was cross-sectionally evaluated between 2011 and 2013 to assess muscle strength in 5039 male workers aged 40 to 64 years. Weight and height were measured, and overweight/obesity was defined as a body mass index ≥25 kg/m2. The prevalence of type 2 diabetes, defined as fasting plasma glucose ≥126 mg/dL and/or hemoglobin A1c ≥6.5% and/or self-reported physician-diagnosed diabetes, was evaluated. Odds ratios (OR) and 95% confidence intervals (95% CI) for the prevalence of type 2 diabetes were obtained using a logistic regression model. Results: In total, 611 participants had type 2 diabetes, and 1763 participants were overweight/obese. After adjustment for covariates, we found an inverse association between muscle strength and the prevalence of type 2 diabetes (P for trend <0.01). In addition, when the analyses were stratified by obesity status, the multivariable-adjusted OR per 2-standard-deviation increase in muscle strength was 0.64 (95% CI, 0.49–0.83) in the overweight/obese group, compared to a weaker relationship in the normal-weight group (OR 0.79 per 2-standard-deviation increase; 95% CI, 0.60–1.06). Conclusions: Dynapenia, an age-related decrease in muscle strength, is associated with increased prevalence of type 2 diabetes, and this relationship is stronger in overweight/obese middle-aged Japanese men than in normal-weight men.https://www.jstage.jst.go.jp/article/jea/25/10/25_JE20140256/_pdfmuscle strengthhand strengthbody mass indexhyperglycemiadynapenia |
| spellingShingle | Ryoko Kawakami Dynapenic Obesity and Prevalence of Type 2 Diabetes in Middle-Aged Japanese Men Journal of Epidemiology muscle strength hand strength body mass index hyperglycemia dynapenia |
| title | Dynapenic Obesity and Prevalence of Type 2 Diabetes in Middle-Aged Japanese Men |
| title_full | Dynapenic Obesity and Prevalence of Type 2 Diabetes in Middle-Aged Japanese Men |
| title_fullStr | Dynapenic Obesity and Prevalence of Type 2 Diabetes in Middle-Aged Japanese Men |
| title_full_unstemmed | Dynapenic Obesity and Prevalence of Type 2 Diabetes in Middle-Aged Japanese Men |
| title_short | Dynapenic Obesity and Prevalence of Type 2 Diabetes in Middle-Aged Japanese Men |
| title_sort | dynapenic obesity and prevalence of type 2 diabetes in middle aged japanese men |
| topic | muscle strength hand strength body mass index hyperglycemia dynapenia |
| url | https://www.jstage.jst.go.jp/article/jea/25/10/25_JE20140256/_pdf |
| work_keys_str_mv | AT ryokokawakami dynapenicobesityandprevalenceoftype2diabetesinmiddleagedjapanesemen |