From Rust to Quantum Biology: The Role of Iron in Retina Physiopathology
Iron is essential for cell survival and function. It is a transition metal, that could change its oxidation state from Fe<sup>2+</sup> to Fe<sup>3+</sup> involving an electron transfer, the key of vital functions but also organ dysfunctions. The goal of this review is to illu...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-03-01
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| Series: | Cells |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2073-4409/9/3/705 |
| _version_ | 1827853565531521024 |
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| author | Emilie Picard Alejandra Daruich Jenny Youale Yves Courtois Francine Behar-Cohen |
| author_facet | Emilie Picard Alejandra Daruich Jenny Youale Yves Courtois Francine Behar-Cohen |
| author_sort | Emilie Picard |
| collection | DOAJ |
| description | Iron is essential for cell survival and function. It is a transition metal, that could change its oxidation state from Fe<sup>2+</sup> to Fe<sup>3+</sup> involving an electron transfer, the key of vital functions but also organ dysfunctions. The goal of this review is to illustrate the primordial role of iron and local iron homeostasis in retinal physiology and vision, as well as the pathological consequences of iron excess in animal models of retinal degeneration and in human retinal diseases. We summarize evidence of the potential therapeutic effect of iron chelation in retinal diseases and especially the interest of transferrin, a ubiquitous endogenous iron-binding protein, having the ability to treat or delay degenerative retinal diseases. |
| first_indexed | 2024-03-12T11:07:34Z |
| format | Article |
| id | doaj.art-7803174363dd40d6a83560130a3ed785 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-12T11:07:34Z |
| publishDate | 2020-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-7803174363dd40d6a83560130a3ed7852023-09-02T03:34:05ZengMDPI AGCells2073-44092020-03-019370510.3390/cells9030705cells9030705From Rust to Quantum Biology: The Role of Iron in Retina PhysiopathologyEmilie Picard0Alejandra Daruich1Jenny Youale2Yves Courtois3Francine Behar-Cohen4Centre de Recherche des Cordeliers, INSERM, Sorbonne Université, USPC, Université Paris Descartes, Team 17, F-75006 Paris, FranceCentre de Recherche des Cordeliers, INSERM, Sorbonne Université, USPC, Université Paris Descartes, Team 17, F-75006 Paris, FranceCentre de Recherche des Cordeliers, INSERM, Sorbonne Université, USPC, Université Paris Descartes, Team 17, F-75006 Paris, FranceCentre de Recherche des Cordeliers, INSERM, Sorbonne Université, USPC, Université Paris Descartes, Team 17, F-75006 Paris, FranceCentre de Recherche des Cordeliers, INSERM, Sorbonne Université, USPC, Université Paris Descartes, Team 17, F-75006 Paris, FranceIron is essential for cell survival and function. It is a transition metal, that could change its oxidation state from Fe<sup>2+</sup> to Fe<sup>3+</sup> involving an electron transfer, the key of vital functions but also organ dysfunctions. The goal of this review is to illustrate the primordial role of iron and local iron homeostasis in retinal physiology and vision, as well as the pathological consequences of iron excess in animal models of retinal degeneration and in human retinal diseases. We summarize evidence of the potential therapeutic effect of iron chelation in retinal diseases and especially the interest of transferrin, a ubiquitous endogenous iron-binding protein, having the ability to treat or delay degenerative retinal diseases.https://www.mdpi.com/2073-4409/9/3/705ironretinatransferrin |
| spellingShingle | Emilie Picard Alejandra Daruich Jenny Youale Yves Courtois Francine Behar-Cohen From Rust to Quantum Biology: The Role of Iron in Retina Physiopathology Cells iron retina transferrin |
| title | From Rust to Quantum Biology: The Role of Iron in Retina Physiopathology |
| title_full | From Rust to Quantum Biology: The Role of Iron in Retina Physiopathology |
| title_fullStr | From Rust to Quantum Biology: The Role of Iron in Retina Physiopathology |
| title_full_unstemmed | From Rust to Quantum Biology: The Role of Iron in Retina Physiopathology |
| title_short | From Rust to Quantum Biology: The Role of Iron in Retina Physiopathology |
| title_sort | from rust to quantum biology the role of iron in retina physiopathology |
| topic | iron retina transferrin |
| url | https://www.mdpi.com/2073-4409/9/3/705 |
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