A Novel Shigella O-Polysaccharide–IpaB Conjugate Vaccine Elicits Robust Antibody Responses and Confers Protection against Multiple Shigella Serotypes

A Novel Shigella O-Polysaccharide–IpaB Conjugate Vaccine Elicits Robust Antibody Responses and Confers Protection against Multiple Shigella Serotypes

ABSTRACT Shigella is responsible for high burdens of diarrhea and dysentery globally. Children living in areas of endemicity are the most affected, and currently, there are no licensed vaccines to prevent shigellosis. Vaccine approaches have traditionally targeted the bacterial lipopolysaccharide as...

Full description

Bibliographic Details
Main Authors: Girmay Desalegn, Neeraj Kapoor, Lucy Pill-Pepe, Leslie Bautista, Lu Yin, Esther Ndungo, Edwin V. Oaks, Jeff Fairman, Marcela F. Pasetti
Format: Article
Language:English
Published: American Society for Microbiology 2023-06-01
Series:mSphere
Subjects:
Shigella
conjugate vaccine
O-polysaccharide (OPS)
IpaB
antibody
protection
Online Access:https://journals.asm.org/doi/10.1128/msphere.00019-23

Internet

https://journals.asm.org/doi/10.1128/msphere.00019-23

Similar Items