Association of Low Vitamin D Level Status and Risk of Pre-Eclampsia and Preterm Birth in Women Using Low-Dose Aspirin

Objective: To determine the association between low Vitamin-D status and risk of pre-eclampsia and preterm birth in women using low-dose Aspirin in the tertiary care setting. Study Design: Prospective comparative study. Place and Duration of Study: Gynecology and Obstetrics Department, Pak Em...

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Main Authors: Urooj Hina, Abeera Choudry, Saira Saeed, Faiza Khanam, Uzma Urooj
Format: Article
Language:English
Published: Army Medical College Rawalpindi 2022-11-01
Series:Pakistan Armed Forces Medical Journal
Subjects:
Online Access:https://www.pafmj.org/index.php/PAFMJ/article/view/5383
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author Urooj Hina
Abeera Choudry
Saira Saeed
Faiza Khanam
Uzma Urooj
author_facet Urooj Hina
Abeera Choudry
Saira Saeed
Faiza Khanam
Uzma Urooj
author_sort Urooj Hina
collection DOAJ
description Objective: To determine the association between low Vitamin-D status and risk of pre-eclampsia and preterm birth in women using low-dose Aspirin in the tertiary care setting. Study Design: Prospective comparative study. Place and Duration of Study: Gynecology and Obstetrics Department, Pak Emirates Military Hospital, Rawalpindi Pakistan from Sep 2018 to Sep 2019. Methodology: A total of 383 pregnant women were divided into three Groups. Pregnant women were included based on the criteria; if one of the five high-risk factors or more than one moderate risk factors were met. High-risk factors were; 1) Type-1 or 2 diabetes mellitus, 2) chronic hypertension, 3) hypertensive disease in previous pregnancy, 4) autoimmune disease such as systemic lupus erythematous or antiphospholipid syndrome, 5) chronic kidney disease. Results: There were 127 pregnant women in Group-1 with Vitamin-D deficiency. In Group-2, there were pregnant women with Vitamin-D insufficiency; in Group-3, there were 18 pregnant women with Vitamin-D sufficiency. The mean Vitamin-D level in Group-1 was 22.40±1.50 nmol/L, the mean Vitamin-D level in Group-2 was 32.82±9.80nmol/L and in Group-3 mean Vitamin-D level was 76.63±8.00 nmol/L. Early onset pre-eclampsia, chronic hypertension with superimposed pre-eclampsia,gestational diabetes, spontaneous-vaginal delivery and delivery at term were found to statistically significant among the Groups (p<0.05). Conclusion: We aimed to determine whether vitamin D status was linked with high-risk pregnancies, which could overshadow the impact of vitamin D under existing conditions. Our findings help relate the status and pre-eclampsia of maternal vitamin D to preterm birth.
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spelling doaj.art-7807a46b240742629a37c0f2d9c329412022-12-22T04:36:21ZengArmy Medical College RawalpindiPakistan Armed Forces Medical Journal0030-96482411-88422022-11-0172510.51253/pafmj.v72i5.5383Association of Low Vitamin D Level Status and Risk of Pre-Eclampsia and Preterm Birth in Women Using Low-Dose AspirinUrooj Hina0Abeera Choudry1Saira Saeed2Faiza Khanam3Uzma Urooj4Combined Military Hospital, Quetta/National University of Medical Science (NUMS) PakistanPak Emirates Military Hospital/ National University of Medical Science (NUMS) Rawalpindi PakistanCombined Military Hospital, Quetta/National University of Medical Science (NUMS) PakistanCombined Military Hospital, Quetta/National University of Medical Science (NUMS) PakistanPak Emirates Military Hospital/ National University of Medical Science (NUMS) Rawalpindi Pakistan Objective: To determine the association between low Vitamin-D status and risk of pre-eclampsia and preterm birth in women using low-dose Aspirin in the tertiary care setting. Study Design: Prospective comparative study. Place and Duration of Study: Gynecology and Obstetrics Department, Pak Emirates Military Hospital, Rawalpindi Pakistan from Sep 2018 to Sep 2019. Methodology: A total of 383 pregnant women were divided into three Groups. Pregnant women were included based on the criteria; if one of the five high-risk factors or more than one moderate risk factors were met. High-risk factors were; 1) Type-1 or 2 diabetes mellitus, 2) chronic hypertension, 3) hypertensive disease in previous pregnancy, 4) autoimmune disease such as systemic lupus erythematous or antiphospholipid syndrome, 5) chronic kidney disease. Results: There were 127 pregnant women in Group-1 with Vitamin-D deficiency. In Group-2, there were pregnant women with Vitamin-D insufficiency; in Group-3, there were 18 pregnant women with Vitamin-D sufficiency. The mean Vitamin-D level in Group-1 was 22.40±1.50 nmol/L, the mean Vitamin-D level in Group-2 was 32.82±9.80nmol/L and in Group-3 mean Vitamin-D level was 76.63±8.00 nmol/L. Early onset pre-eclampsia, chronic hypertension with superimposed pre-eclampsia,gestational diabetes, spontaneous-vaginal delivery and delivery at term were found to statistically significant among the Groups (p<0.05). Conclusion: We aimed to determine whether vitamin D status was linked with high-risk pregnancies, which could overshadow the impact of vitamin D under existing conditions. Our findings help relate the status and pre-eclampsia of maternal vitamin D to preterm birth. https://www.pafmj.org/index.php/PAFMJ/article/view/5383AspirinLabourPre-eclampsiaVitamin-D
spellingShingle Urooj Hina
Abeera Choudry
Saira Saeed
Faiza Khanam
Uzma Urooj
Association of Low Vitamin D Level Status and Risk of Pre-Eclampsia and Preterm Birth in Women Using Low-Dose Aspirin
Pakistan Armed Forces Medical Journal
Aspirin
Labour
Pre-eclampsia
Vitamin-D
title Association of Low Vitamin D Level Status and Risk of Pre-Eclampsia and Preterm Birth in Women Using Low-Dose Aspirin
title_full Association of Low Vitamin D Level Status and Risk of Pre-Eclampsia and Preterm Birth in Women Using Low-Dose Aspirin
title_fullStr Association of Low Vitamin D Level Status and Risk of Pre-Eclampsia and Preterm Birth in Women Using Low-Dose Aspirin
title_full_unstemmed Association of Low Vitamin D Level Status and Risk of Pre-Eclampsia and Preterm Birth in Women Using Low-Dose Aspirin
title_short Association of Low Vitamin D Level Status and Risk of Pre-Eclampsia and Preterm Birth in Women Using Low-Dose Aspirin
title_sort association of low vitamin d level status and risk of pre eclampsia and preterm birth in women using low dose aspirin
topic Aspirin
Labour
Pre-eclampsia
Vitamin-D
url https://www.pafmj.org/index.php/PAFMJ/article/view/5383
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