Proteomic profiling of postmortem prefrontal cortex tissue of suicide completers
Abstract Suicide is a leading cause of death worldwide, presenting a serious public health problem. We aimed to investigate the biological basis of suicide completion using proteomics on postmortem brain tissue. Thirty-six postmortem brain samples (23 suicide completers and 13 controls) were collect...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2022-04-01
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| Series: | Translational Psychiatry |
| Online Access: | https://doi.org/10.1038/s41398-022-01896-z |
| _version_ | 1819210467202039808 |
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| author | Min Ji Kim Misol Do Dohyun Han Minsoo Son Dongyoon Shin Injoon Yeo Young Hyun Yun Seong Ho Yoo Hyung Jin Choi Daun Shin Sang Jin Rhee Yong Min Ahn Youngsoo Kim |
| author_facet | Min Ji Kim Misol Do Dohyun Han Minsoo Son Dongyoon Shin Injoon Yeo Young Hyun Yun Seong Ho Yoo Hyung Jin Choi Daun Shin Sang Jin Rhee Yong Min Ahn Youngsoo Kim |
| author_sort | Min Ji Kim |
| collection | DOAJ |
| description | Abstract Suicide is a leading cause of death worldwide, presenting a serious public health problem. We aimed to investigate the biological basis of suicide completion using proteomics on postmortem brain tissue. Thirty-six postmortem brain samples (23 suicide completers and 13 controls) were collected. We evaluated the proteomic profile in the prefrontal cortex (Broadmann area 9, 10) using tandem mass tag-based quantification with liquid chromatography–tandem mass spectrometry. Bioinformatics tools were used to elucidate the biological mechanisms related to suicide. Subgroup analysis was conducted to identify common differentially expressed proteins among clinically different groups. Of 9801 proteins identified, 295 were differentially expressed between groups. Suicide completion samples were mostly enriched in the endocannabinoid and apoptotic pathways (CAPNS1, CSNK2B, PTP4A2). Among the differentially expressed proteins, GSTT1 was identified as a potential biomarker among suicide completers with psychiatric disorders. Our findings suggest that the previously under-recognized endocannabinoid system and apoptotic processes are highly involved in suicide. |
| first_indexed | 2024-12-23T06:11:38Z |
| format | Article |
| id | doaj.art-7808445bba3047748e7a33f1ea45295a |
| institution | Directory Open Access Journal |
| issn | 2158-3188 |
| language | English |
| last_indexed | 2024-12-23T06:11:38Z |
| publishDate | 2022-04-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Translational Psychiatry |
| spelling | doaj.art-7808445bba3047748e7a33f1ea45295a2022-12-21T17:57:27ZengNature Publishing GroupTranslational Psychiatry2158-31882022-04-0112111010.1038/s41398-022-01896-zProteomic profiling of postmortem prefrontal cortex tissue of suicide completersMin Ji Kim0Misol Do1Dohyun Han2Minsoo Son3Dongyoon Shin4Injoon Yeo5Young Hyun Yun6Seong Ho Yoo7Hyung Jin Choi8Daun Shin9Sang Jin Rhee10Yong Min Ahn11Youngsoo Kim12Department of Neuropsychiatry, Seoul National University HospitalDepartment of Biomedical Engineering, Seoul National University College of MedicineBiomedical Research Institute, Seoul National University HospitalDepartment of Biomedical Engineering, Seoul National University College of MedicineDepartment of Biomedical Sciences, Seoul National University College of MedicineDepartment of Biomedical Engineering, Seoul National University College of MedicineDepartment of Anatomy and Cell Biology, Seoul National University College of MedicineDepartment of Forensic Medicine, Seoul National University College of MedicineDepartment of Biomedical Sciences, Seoul National University College of MedicineDepartment of Neuropsychiatry, Seoul National University HospitalDepartment of Neuropsychiatry, Seoul National University HospitalDepartment of Neuropsychiatry, Seoul National University HospitalDepartment of Biomedical Engineering, Seoul National University College of MedicineAbstract Suicide is a leading cause of death worldwide, presenting a serious public health problem. We aimed to investigate the biological basis of suicide completion using proteomics on postmortem brain tissue. Thirty-six postmortem brain samples (23 suicide completers and 13 controls) were collected. We evaluated the proteomic profile in the prefrontal cortex (Broadmann area 9, 10) using tandem mass tag-based quantification with liquid chromatography–tandem mass spectrometry. Bioinformatics tools were used to elucidate the biological mechanisms related to suicide. Subgroup analysis was conducted to identify common differentially expressed proteins among clinically different groups. Of 9801 proteins identified, 295 were differentially expressed between groups. Suicide completion samples were mostly enriched in the endocannabinoid and apoptotic pathways (CAPNS1, CSNK2B, PTP4A2). Among the differentially expressed proteins, GSTT1 was identified as a potential biomarker among suicide completers with psychiatric disorders. Our findings suggest that the previously under-recognized endocannabinoid system and apoptotic processes are highly involved in suicide.https://doi.org/10.1038/s41398-022-01896-z |
| spellingShingle | Min Ji Kim Misol Do Dohyun Han Minsoo Son Dongyoon Shin Injoon Yeo Young Hyun Yun Seong Ho Yoo Hyung Jin Choi Daun Shin Sang Jin Rhee Yong Min Ahn Youngsoo Kim Proteomic profiling of postmortem prefrontal cortex tissue of suicide completers Translational Psychiatry |
| title | Proteomic profiling of postmortem prefrontal cortex tissue of suicide completers |
| title_full | Proteomic profiling of postmortem prefrontal cortex tissue of suicide completers |
| title_fullStr | Proteomic profiling of postmortem prefrontal cortex tissue of suicide completers |
| title_full_unstemmed | Proteomic profiling of postmortem prefrontal cortex tissue of suicide completers |
| title_short | Proteomic profiling of postmortem prefrontal cortex tissue of suicide completers |
| title_sort | proteomic profiling of postmortem prefrontal cortex tissue of suicide completers |
| url | https://doi.org/10.1038/s41398-022-01896-z |
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