Mechanisms of resistance to EGFR-targeted therapies in colorectal cancer: more than just genetics
The development of acquired resistance to anti-EGFR therapies remains poorly understood, with most research to date exploring, and trying to overcome, various genomic mechanisms of resistance. However, recent work supports a model of resistance whereby transcriptomic mechanisms of resistance predomi...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-09-01
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| Series: | Frontiers in Cell and Developmental Biology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2023.1176657/full |
| _version_ | 1797682401114062848 |
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| author | Christine Parseghian Madhulika Eluri Scott Kopetz Kanwal Raghav |
| author_facet | Christine Parseghian Madhulika Eluri Scott Kopetz Kanwal Raghav |
| author_sort | Christine Parseghian |
| collection | DOAJ |
| description | The development of acquired resistance to anti-EGFR therapies remains poorly understood, with most research to date exploring, and trying to overcome, various genomic mechanisms of resistance. However, recent work supports a model of resistance whereby transcriptomic mechanisms of resistance predominate in the presence of active cytotoxic chemotherapy combined with anti-EGFR therapy in the first-line setting, with a greater predominance of acquired MAPK mutations after single-agent anti-EGFR therapy in the later-line setting. The proposed model has implications for prospective studies evaluating anti-EGFR rechallenge strategies guided by acquired MAPK mutations and highlights the need to address transcriptional mechanisms of resistance. |
| first_indexed | 2024-03-11T23:59:13Z |
| format | Article |
| id | doaj.art-78087fab0b044a409a49a51765c1fb0e |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-03-11T23:59:13Z |
| publishDate | 2023-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-78087fab0b044a409a49a51765c1fb0e2023-09-18T06:27:14ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2023-09-011110.3389/fcell.2023.11766571176657Mechanisms of resistance to EGFR-targeted therapies in colorectal cancer: more than just geneticsChristine Parseghian0Madhulika Eluri1Scott Kopetz2Kanwal Raghav3Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, United StatesDivision of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, United StatesDepartment of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, United StatesDepartment of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, United StatesThe development of acquired resistance to anti-EGFR therapies remains poorly understood, with most research to date exploring, and trying to overcome, various genomic mechanisms of resistance. However, recent work supports a model of resistance whereby transcriptomic mechanisms of resistance predominate in the presence of active cytotoxic chemotherapy combined with anti-EGFR therapy in the first-line setting, with a greater predominance of acquired MAPK mutations after single-agent anti-EGFR therapy in the later-line setting. The proposed model has implications for prospective studies evaluating anti-EGFR rechallenge strategies guided by acquired MAPK mutations and highlights the need to address transcriptional mechanisms of resistance.https://www.frontiersin.org/articles/10.3389/fcell.2023.1176657/fullanti-EGFRanti-EGFR rechallengegenomic mechanisms of resistance to anti-EGFRnon-genomic mechanisms of resistance to anti-EGFRanti-EGFR resistance |
| spellingShingle | Christine Parseghian Madhulika Eluri Scott Kopetz Kanwal Raghav Mechanisms of resistance to EGFR-targeted therapies in colorectal cancer: more than just genetics Frontiers in Cell and Developmental Biology anti-EGFR anti-EGFR rechallenge genomic mechanisms of resistance to anti-EGFR non-genomic mechanisms of resistance to anti-EGFR anti-EGFR resistance |
| title | Mechanisms of resistance to EGFR-targeted therapies in colorectal cancer: more than just genetics |
| title_full | Mechanisms of resistance to EGFR-targeted therapies in colorectal cancer: more than just genetics |
| title_fullStr | Mechanisms of resistance to EGFR-targeted therapies in colorectal cancer: more than just genetics |
| title_full_unstemmed | Mechanisms of resistance to EGFR-targeted therapies in colorectal cancer: more than just genetics |
| title_short | Mechanisms of resistance to EGFR-targeted therapies in colorectal cancer: more than just genetics |
| title_sort | mechanisms of resistance to egfr targeted therapies in colorectal cancer more than just genetics |
| topic | anti-EGFR anti-EGFR rechallenge genomic mechanisms of resistance to anti-EGFR non-genomic mechanisms of resistance to anti-EGFR anti-EGFR resistance |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2023.1176657/full |
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