Coiled-coil structure of meiosis protein TEX12 and conformational regulation by its C-terminal tip

The X-ray crystal structures of C-terminal mutants of the coiled-coil protein cancer testis antigen TEX12 in combination with modeling of the TEX12 wild-type dimer reveal the protein’s control of its oligomeric state, which resembles assembly of its complex with synaptonemal complex central element...

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Bibliographic Details
Main Authors: James M. Dunce, Lucy J. Salmon, Owen R. Davies
Format: Article
Language:English
Published: Nature Portfolio 2022-09-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-022-03886-9