High dose and low dose oxytocin regimens as determinants of successful labor induction: a multicenter comparative study
Abstract Background Induction of labor by Oxytocin is a routine obstetric procedure. However, little is known regarding the optimal dose of oxytocin so as to bring successful induction. This study was aimed at comparing the effects of high dose versus low dose oxytocin regimens on success of labor i...
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| Format: | Article |
| Language: | English |
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BMC
2020-04-01
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| Series: | BMC Pregnancy and Childbirth |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12884-020-02938-4 |
| _version_ | 1817995053790920704 |
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| author | Melese Gezahegn Tesemma Demisew Amenu Sori Desta Hiko Gemeda |
| author_facet | Melese Gezahegn Tesemma Demisew Amenu Sori Desta Hiko Gemeda |
| author_sort | Melese Gezahegn Tesemma |
| collection | DOAJ |
| description | Abstract Background Induction of labor by Oxytocin is a routine obstetric procedure. However, little is known regarding the optimal dose of oxytocin so as to bring successful induction. This study was aimed at comparing the effects of high dose versus low dose oxytocin regimens on success of labor induction. Methods Hospital-based comparative cross-sectional study was conducted in four selected hospitals in Ethiopia prospectively from October 1, 2017 to May 30, 2018. A total of 216 pregnant women who undergo induction of labor at gestational age of 37 weeks and above were included. Data were entered into Epi-data version 3.1 and then exported to SPSS version 20 for cleaning and analysis. Chi-square test and logistic regression were done to look for determinants of successful induction. The result was presented using 95% confidence interval of crude and adjusted odds ratios. P-value < 0.05 was used to declare statistical significance. Result The mean “Induction to delivery time” was 5.9 h and 6.3 h for participants who received high dose Oxytocin and low dose Oxytocin respectively. Higher successful induction (72.2% versus 61.1%) and lower Cesarean Section rate (27.8% vs. 38.9) were observed among participants who received low dose Oxytocin compared to high dose. Favourable bishop score [AOR 4.0 95% CI 1.9, 8.5], elective induction [AOR 0.2 95% CI 0.1, 0.4], performing artificial rupture of membrane [AOR 10.1 95% CI 3.2, 32.2], neonatal birth weight of <4Kg [AOR 4.3, 95% CI 1.6, 11.6] and being parous [AOR 2.1 95% CI 1.1, 4.0] were significantly associated with success of induction. Conclusions In this study, Different oxytocin regimens didn’t show significant association with success of induction. But, high dose oxytocin regimen was significantly associated with slightly shorter induction to delivery time. Favourable bishop score, emergency induction, performing artificial rupture of membrane and delivery to non-macrosomic fetuses were positive determinants of successful induction. We recommend researchers to conduct multicenter research on a large number of patients that controls confounders to see the real effects of different oxytocin regimens on success of labor induction. |
| first_indexed | 2024-04-14T02:00:07Z |
| format | Article |
| id | doaj.art-780f514cbe364fe780d6493b808bc60e |
| institution | Directory Open Access Journal |
| issn | 1471-2393 |
| language | English |
| last_indexed | 2024-04-14T02:00:07Z |
| publishDate | 2020-04-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pregnancy and Childbirth |
| spelling | doaj.art-780f514cbe364fe780d6493b808bc60e2022-12-22T02:18:52ZengBMCBMC Pregnancy and Childbirth1471-23932020-04-012011810.1186/s12884-020-02938-4High dose and low dose oxytocin regimens as determinants of successful labor induction: a multicenter comparative studyMelese Gezahegn Tesemma0Demisew Amenu Sori1Desta Hiko Gemeda2Department of Obstetrics and Gynecology, Arsi UniversityDepartment of Obstetrics and Gynecology, Jimma UniversityDepartment of Epidemiology, Jimma UniversityAbstract Background Induction of labor by Oxytocin is a routine obstetric procedure. However, little is known regarding the optimal dose of oxytocin so as to bring successful induction. This study was aimed at comparing the effects of high dose versus low dose oxytocin regimens on success of labor induction. Methods Hospital-based comparative cross-sectional study was conducted in four selected hospitals in Ethiopia prospectively from October 1, 2017 to May 30, 2018. A total of 216 pregnant women who undergo induction of labor at gestational age of 37 weeks and above were included. Data were entered into Epi-data version 3.1 and then exported to SPSS version 20 for cleaning and analysis. Chi-square test and logistic regression were done to look for determinants of successful induction. The result was presented using 95% confidence interval of crude and adjusted odds ratios. P-value < 0.05 was used to declare statistical significance. Result The mean “Induction to delivery time” was 5.9 h and 6.3 h for participants who received high dose Oxytocin and low dose Oxytocin respectively. Higher successful induction (72.2% versus 61.1%) and lower Cesarean Section rate (27.8% vs. 38.9) were observed among participants who received low dose Oxytocin compared to high dose. Favourable bishop score [AOR 4.0 95% CI 1.9, 8.5], elective induction [AOR 0.2 95% CI 0.1, 0.4], performing artificial rupture of membrane [AOR 10.1 95% CI 3.2, 32.2], neonatal birth weight of <4Kg [AOR 4.3, 95% CI 1.6, 11.6] and being parous [AOR 2.1 95% CI 1.1, 4.0] were significantly associated with success of induction. Conclusions In this study, Different oxytocin regimens didn’t show significant association with success of induction. But, high dose oxytocin regimen was significantly associated with slightly shorter induction to delivery time. Favourable bishop score, emergency induction, performing artificial rupture of membrane and delivery to non-macrosomic fetuses were positive determinants of successful induction. We recommend researchers to conduct multicenter research on a large number of patients that controls confounders to see the real effects of different oxytocin regimens on success of labor induction.http://link.springer.com/article/10.1186/s12884-020-02938-4InductionHigh dose oxytocinLow dose oxytocinSuccessful inductionFailed inductionInduction to delivery time |
| spellingShingle | Melese Gezahegn Tesemma Demisew Amenu Sori Desta Hiko Gemeda High dose and low dose oxytocin regimens as determinants of successful labor induction: a multicenter comparative study BMC Pregnancy and Childbirth Induction High dose oxytocin Low dose oxytocin Successful induction Failed induction Induction to delivery time |
| title | High dose and low dose oxytocin regimens as determinants of successful labor induction: a multicenter comparative study |
| title_full | High dose and low dose oxytocin regimens as determinants of successful labor induction: a multicenter comparative study |
| title_fullStr | High dose and low dose oxytocin regimens as determinants of successful labor induction: a multicenter comparative study |
| title_full_unstemmed | High dose and low dose oxytocin regimens as determinants of successful labor induction: a multicenter comparative study |
| title_short | High dose and low dose oxytocin regimens as determinants of successful labor induction: a multicenter comparative study |
| title_sort | high dose and low dose oxytocin regimens as determinants of successful labor induction a multicenter comparative study |
| topic | Induction High dose oxytocin Low dose oxytocin Successful induction Failed induction Induction to delivery time |
| url | http://link.springer.com/article/10.1186/s12884-020-02938-4 |
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