The Effect of Fenugreek (Trigonella Foecum Graecum) Intake on the Oxidative Stress in Hypercholesterolaemic Subjects
Introduction: The consumption of fenugreek (Trigonella Foecum Graecum) has been seen to have antidiabetic and hypolipedaemic effects. Hypercholesterolemia is a substrate for lipid per oxidation. An increased lipid per oxidation leads to oxidative stress. When the lipid levels are lowered, we can...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Pvt. Ltd.
2013-01-01
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| Series: | National Journal of Laboratory Medicine |
| Subjects: | |
| Online Access: | http://www.njlm.net/articles/PDF/1963/2-%204616_E(C)_PF1(R)_F(P)_PFA(P)_OLF(P)_U_4_PF1(PH)pdf.pdf |
| Summary: | Introduction: The consumption of fenugreek (Trigonella
Foecum Graecum) has been seen to have antidiabetic and
hypolipedaemic effects. Hypercholesterolemia is a substrate
for lipid per oxidation. An increased lipid per oxidation leads
to oxidative stress. When the lipid levels are lowered, we can
expect a reduction in the lipid per oxidation, which reduces
the oxidative stress. Oxidative stress is a well established
factor in the pathogenesis of ageing to deadly disease like
carcinoma.
Objective: The purpose of this research was to study the
effect of fenugreek intake on the oxidant and the antioxidant
status in hyperlipedaemic subjects.
Method: Twenty subjects with an elevated lipid profile were
included in this study. A detailed history was taken and
clinical examinations were done for all the patients. They
were grouped into two. The first group was treated with
placebo for 30 days. The second group was treated with
Trigonella Foecum powder (fenugreek) for 30 days. Fasting
blood samples were taken from both the groups before and
after the 30th day of the intake of placebo and fenugreek.
The blood levels of MDA (oxidant) and Caeruloplasmin
(antioxidant were estimated. Their levels before and after
the intake of placebo and fenugreek were compared
statistically.
Results: The levels of MDA and Caeruloplasmin were
found to be reduced significantly following the fenugreek
consumption as compared to their pre treatment levels.
No significant difference was found in the controls who
consumed placebo.
Conclusion: This study proved that a regular intake of
fenugreek could reduce the oxidative stress by reducing the
lipid per oxidation. |
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| ISSN: | 2277-8551 2455-6882 |