The Effect of Fenugreek (Trigonella Foecum Graecum) Intake on the Oxidative Stress in Hypercholesterolaemic Subjects
Introduction: The consumption of fenugreek (Trigonella Foecum Graecum) has been seen to have antidiabetic and hypolipedaemic effects. Hypercholesterolemia is a substrate for lipid per oxidation. An increased lipid per oxidation leads to oxidative stress. When the lipid levels are lowered, we can...
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| Format: | Article |
| Language: | English |
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JCDR Research and Publications Pvt. Ltd.
2013-01-01
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| Series: | National Journal of Laboratory Medicine |
| Subjects: | |
| Online Access: | http://www.njlm.net/articles/PDF/1963/2-%204616_E(C)_PF1(R)_F(P)_PFA(P)_OLF(P)_U_4_PF1(PH)pdf.pdf |
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| author | M.R. Renuka Dev B. Jaya R. Nandhini Madhanika Madhavan P. Saikumar |
| author_facet | M.R. Renuka Dev B. Jaya R. Nandhini Madhanika Madhavan P. Saikumar |
| author_sort | M.R. Renuka Dev |
| collection | DOAJ |
| description | Introduction: The consumption of fenugreek (Trigonella
Foecum Graecum) has been seen to have antidiabetic and
hypolipedaemic effects. Hypercholesterolemia is a substrate
for lipid per oxidation. An increased lipid per oxidation leads
to oxidative stress. When the lipid levels are lowered, we can
expect a reduction in the lipid per oxidation, which reduces
the oxidative stress. Oxidative stress is a well established
factor in the pathogenesis of ageing to deadly disease like
carcinoma.
Objective: The purpose of this research was to study the
effect of fenugreek intake on the oxidant and the antioxidant
status in hyperlipedaemic subjects.
Method: Twenty subjects with an elevated lipid profile were
included in this study. A detailed history was taken and
clinical examinations were done for all the patients. They
were grouped into two. The first group was treated with
placebo for 30 days. The second group was treated with
Trigonella Foecum powder (fenugreek) for 30 days. Fasting
blood samples were taken from both the groups before and
after the 30th day of the intake of placebo and fenugreek.
The blood levels of MDA (oxidant) and Caeruloplasmin
(antioxidant were estimated. Their levels before and after
the intake of placebo and fenugreek were compared
statistically.
Results: The levels of MDA and Caeruloplasmin were
found to be reduced significantly following the fenugreek
consumption as compared to their pre treatment levels.
No significant difference was found in the controls who
consumed placebo.
Conclusion: This study proved that a regular intake of
fenugreek could reduce the oxidative stress by reducing the
lipid per oxidation. |
| first_indexed | 2024-12-10T17:54:54Z |
| format | Article |
| id | doaj.art-781003e2716f4631bc2b5d2833d45e1a |
| institution | Directory Open Access Journal |
| issn | 2277-8551 2455-6882 |
| language | English |
| last_indexed | 2024-12-10T17:54:54Z |
| publishDate | 2013-01-01 |
| publisher | JCDR Research and Publications Pvt. Ltd. |
| record_format | Article |
| series | National Journal of Laboratory Medicine |
| spelling | doaj.art-781003e2716f4631bc2b5d2833d45e1a2022-12-22T01:38:58ZengJCDR Research and Publications Pvt. Ltd.National Journal of Laboratory Medicine2277-85512455-68822013-01-01215710.7860/NJLM/2013/4616:0003The Effect of Fenugreek (Trigonella Foecum Graecum) Intake on the Oxidative Stress in Hypercholesterolaemic SubjectsM.R. Renuka Dev0 B. Jaya1R. Nandhini2Madhanika Madhavan3P. Saikumar4Associate Professor, Department of Physiology, Sree Balaji Medical College And Hospital, Chromepet, Chennai-78,IndiaPost Graduate Department of Physiology, Sree Balaji Medical College And Hospital, Chromepet, Chennai-78, India.Professor, Department of Physiology, Sree Balaji Medical College And Hospital, Chromepet, Chennai-78, India.Professor, Department of Physiology, Sree Balaji Medical College And Hospital, Chromepet, Chennai-78, India.Professor And Hod, Department of Physiology, Sree Balaji Medical College And HoSpital, Chromepet, Chennai-78, India.Introduction: The consumption of fenugreek (Trigonella Foecum Graecum) has been seen to have antidiabetic and hypolipedaemic effects. Hypercholesterolemia is a substrate for lipid per oxidation. An increased lipid per oxidation leads to oxidative stress. When the lipid levels are lowered, we can expect a reduction in the lipid per oxidation, which reduces the oxidative stress. Oxidative stress is a well established factor in the pathogenesis of ageing to deadly disease like carcinoma. Objective: The purpose of this research was to study the effect of fenugreek intake on the oxidant and the antioxidant status in hyperlipedaemic subjects. Method: Twenty subjects with an elevated lipid profile were included in this study. A detailed history was taken and clinical examinations were done for all the patients. They were grouped into two. The first group was treated with placebo for 30 days. The second group was treated with Trigonella Foecum powder (fenugreek) for 30 days. Fasting blood samples were taken from both the groups before and after the 30th day of the intake of placebo and fenugreek. The blood levels of MDA (oxidant) and Caeruloplasmin (antioxidant were estimated. Their levels before and after the intake of placebo and fenugreek were compared statistically. Results: The levels of MDA and Caeruloplasmin were found to be reduced significantly following the fenugreek consumption as compared to their pre treatment levels. No significant difference was found in the controls who consumed placebo. Conclusion: This study proved that a regular intake of fenugreek could reduce the oxidative stress by reducing the lipid per oxidation.http://www.njlm.net/articles/PDF/1963/2-%204616_E(C)_PF1(R)_F(P)_PFA(P)_OLF(P)_U_4_PF1(PH)pdf.pdfcaeruloplasminmda (malon di aldehyde)fenugreekoxidative stress |
| spellingShingle | M.R. Renuka Dev B. Jaya R. Nandhini Madhanika Madhavan P. Saikumar The Effect of Fenugreek (Trigonella Foecum Graecum) Intake on the Oxidative Stress in Hypercholesterolaemic Subjects National Journal of Laboratory Medicine caeruloplasmin mda (malon di aldehyde) fenugreek oxidative stress |
| title | The Effect of Fenugreek (Trigonella Foecum Graecum) Intake on the Oxidative Stress in Hypercholesterolaemic Subjects |
| title_full | The Effect of Fenugreek (Trigonella Foecum Graecum) Intake on the Oxidative Stress in Hypercholesterolaemic Subjects |
| title_fullStr | The Effect of Fenugreek (Trigonella Foecum Graecum) Intake on the Oxidative Stress in Hypercholesterolaemic Subjects |
| title_full_unstemmed | The Effect of Fenugreek (Trigonella Foecum Graecum) Intake on the Oxidative Stress in Hypercholesterolaemic Subjects |
| title_short | The Effect of Fenugreek (Trigonella Foecum Graecum) Intake on the Oxidative Stress in Hypercholesterolaemic Subjects |
| title_sort | effect of fenugreek trigonella foecum graecum intake on the oxidative stress in hypercholesterolaemic subjects |
| topic | caeruloplasmin mda (malon di aldehyde) fenugreek oxidative stress |
| url | http://www.njlm.net/articles/PDF/1963/2-%204616_E(C)_PF1(R)_F(P)_PFA(P)_OLF(P)_U_4_PF1(PH)pdf.pdf |
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