A case study of disseminated histoplasmosis linked to common variable immunodeficiency
Histoplasma capsulatum, a ground fungus, can infect humans, normally in endemic areas; the resulting disease can be asymptomatic or it can have a benign development, but in rare cases it can develop into a serious clinical condition and can even be fatal. Its most characteristic initial location is...
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| Format: | Article |
| Language: | English |
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Elsevier
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| Series: | Brazilian Journal of Infectious Diseases |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702003000400007&lng=en&tlng=en |
| _version_ | 1819050625049034752 |
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| author | Acir Rachid Lucila Stange Rezende Suzelle Freitas de Moura Paulo C. Loffy Francisco Luiz Gomide M. Magalhães |
| author_facet | Acir Rachid Lucila Stange Rezende Suzelle Freitas de Moura Paulo C. Loffy Francisco Luiz Gomide M. Magalhães |
| author_sort | Acir Rachid |
| collection | DOAJ |
| description | Histoplasma capsulatum, a ground fungus, can infect humans, normally in endemic areas; the resulting disease can be asymptomatic or it can have a benign development, but in rare cases it can develop into a serious clinical condition and can even be fatal. Its most characteristic initial location is in the lungs, resembling tuberculosis, often accompanied by mediastinitis and an exuberant fibrotic response. The spread of this infection can be caused by the concomitance of another illness that alters the immunological balance. Sometimes such an association is not clear. Therefore, disseminated histoplasmosis is defined as a clinical condition where the fungus is present in more than one location. Common variable immunodeficiency is characterized by a generalized failure in the synthesis of antibodies, leading the affected individuals to present recurrent infections, especially those caused by encapsulated bacteria, most often involving the respiratory tract. We studied a serious case of disseminated histoplasmosis, accompanied by common variable immunodeficiency, observed at the Infirmary of the department of Medical Practice of the Federal University at Paraná Hospital das Clínicas. |
| first_indexed | 2024-12-21T11:51:01Z |
| format | Article |
| id | doaj.art-781588eaa5dd4143a2ed653d3b00fc23 |
| institution | Directory Open Access Journal |
| issn | 1678-4391 |
| language | English |
| last_indexed | 2024-12-21T11:51:01Z |
| publisher | Elsevier |
| record_format | Article |
| series | Brazilian Journal of Infectious Diseases |
| spelling | doaj.art-781588eaa5dd4143a2ed653d3b00fc232022-12-21T19:05:04ZengElsevierBrazilian Journal of Infectious Diseases1678-43917426827210.1590/S1413-86702003000400007S1413-86702003000400007A case study of disseminated histoplasmosis linked to common variable immunodeficiencyAcir Rachid0Lucila Stange Rezende1Suzelle Freitas de Moura2Paulo C. Loffy3Francisco Luiz Gomide M. Magalhães4Universidade Federal do ParanáUniversidade Federal do ParanáUniversidade Federal do ParanáUniversidade Federal do ParanáUniversidade Federal do ParanáHistoplasma capsulatum, a ground fungus, can infect humans, normally in endemic areas; the resulting disease can be asymptomatic or it can have a benign development, but in rare cases it can develop into a serious clinical condition and can even be fatal. Its most characteristic initial location is in the lungs, resembling tuberculosis, often accompanied by mediastinitis and an exuberant fibrotic response. The spread of this infection can be caused by the concomitance of another illness that alters the immunological balance. Sometimes such an association is not clear. Therefore, disseminated histoplasmosis is defined as a clinical condition where the fungus is present in more than one location. Common variable immunodeficiency is characterized by a generalized failure in the synthesis of antibodies, leading the affected individuals to present recurrent infections, especially those caused by encapsulated bacteria, most often involving the respiratory tract. We studied a serious case of disseminated histoplasmosis, accompanied by common variable immunodeficiency, observed at the Infirmary of the department of Medical Practice of the Federal University at Paraná Hospital das Clínicas.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702003000400007&lng=en&tlng=enDisseminated histoplasmosiscommon variable immunodeficiencyimmunoglobulins |
| spellingShingle | Acir Rachid Lucila Stange Rezende Suzelle Freitas de Moura Paulo C. Loffy Francisco Luiz Gomide M. Magalhães A case study of disseminated histoplasmosis linked to common variable immunodeficiency Brazilian Journal of Infectious Diseases Disseminated histoplasmosis common variable immunodeficiency immunoglobulins |
| title | A case study of disseminated histoplasmosis linked to common variable immunodeficiency |
| title_full | A case study of disseminated histoplasmosis linked to common variable immunodeficiency |
| title_fullStr | A case study of disseminated histoplasmosis linked to common variable immunodeficiency |
| title_full_unstemmed | A case study of disseminated histoplasmosis linked to common variable immunodeficiency |
| title_short | A case study of disseminated histoplasmosis linked to common variable immunodeficiency |
| title_sort | case study of disseminated histoplasmosis linked to common variable immunodeficiency |
| topic | Disseminated histoplasmosis common variable immunodeficiency immunoglobulins |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702003000400007&lng=en&tlng=en |
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