Contribution of MMP14-expressing cancer-associated fibroblasts in the tumor immune microenvironment to progression of colorectal cancer

Contribution of MMP14-expressing cancer-associated fibroblasts in the tumor immune microenvironment to progression of colorectal cancer

Matrix metalloproteinase 14 (MMP14) expression is implicated in progression of colorectal cancer, but its role in the tumor microenvironment (TME) has been unclear. The relevance of MMP14 to colorectal cancer progression was explored by analysis of transcriptomic data for colorectal adenocarcinoma p...

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Bibliographic Details
Main Authors: Yusuke Makutani, Hisato Kawakami, Takahiro Tsujikawa, Kanako Yoshimura, Yasutaka Chiba, Akihiko Ito, Junichiro Kawamura, Koji Haratani, Kazuhiko Nakagawa
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Oncology
Subjects:
colorectal cancer
matrix metalloproteinase 14 (MMP14)
multiplex immunohistochemistry (mIHC)
cancer-associated fibroblast (CAF)
M2 tumor-associated macrophages (M2-TAMs)
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.956270/full

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https://www.frontiersin.org/articles/10.3389/fonc.2022.956270/full

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