Relationship of Bacteria Isolated from Antral Gastric Biopsy with the Incidence of Dyspepsia in Patients Referred to Mehrad and Labbafinejad Hospitals, Tehran, Iran, in 2018
Introduction: This descriptive cross-sectional study examined the association between the presence of four non-Helicobacter-pylori bacterial species (e.g., Staphylococcus aureus, Lactobacillus acidophilus, Pseudomonas aeruginosa, and Streptococcus sanguis) and dyspepsia. Material & Methods: This...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | fas |
| Published: |
Ilam University of Medical Sciences
2022-03-01
|
| Series: | Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Īlām |
| Subjects: | |
| Online Access: | http://sjimu.medilam.ac.ir/article-1-7104-en.html |
| _version_ | 1828265889643888640 |
|---|---|
| author | Mahnaz Mohammadi Amin Talebi Bezmin Abadi Farid Rahimi Mojgan Forootan |
| author_facet | Mahnaz Mohammadi Amin Talebi Bezmin Abadi Farid Rahimi Mojgan Forootan |
| author_sort | Mahnaz Mohammadi |
| collection | DOAJ |
| description | Introduction: This descriptive cross-sectional study examined the association between the presence of four non-Helicobacter-pylori bacterial species (e.g., Staphylococcus aureus, Lactobacillus acidophilus, Pseudomonas aeruginosa, and Streptococcus sanguis) and dyspepsia.
Material & Methods: This study included a total of 100 antral biopsy samples isolated from dyspeptic (n=50) or non-dyspeptic (healthy control) (n=50) patients referred to Mehrad and Labafinejad Hospitals, Tehran, Iran, in 2018. Following that, the presence of Staphylococcus aureus, Lactobacillus acidophilus, Pseudomonas aeruginosa, and Streptococcus sanguis was investigated by PCR and using their respective primers, including nuc, PA431CF, iga, and 16s rRNA.
Ethics Code (IR.MODARES.REC.1397.241) .
Findings: In this study, a total of 50 antral biopsies were isolated from patients with dyspepsia, and 50 antral biopsy specimens were isolated from individuals without dyspepsia during endoscopy. The mean age of the subjects was 48 years (age range: 16-80 years); moreover, the highest age group belonged to the group of 26-46 (24%) years, and the lowest age belonged to the group of 16-26 years (0.06%). The age ranges used in this study had a relatively good population distribution. According to the results of the PCR test, the prevalence rates of Staphylococcus aureus, Lactobacillus acidophilus, Pseudomonas aeruginosa, and Streptococcus sanguis in dyspeptic patients (n=50) were 23 (46%), 3 (6%), 42 (84%), and 0 (0 %), respectively. Moreover, the corresponding prevalence values were 19 (38%), 10 (20%), 45 (90%), and 2 (4%) among the non-dyspeptic control individuals. The presence of these bacteria showed no statistically significant association with the incidence of dyspepsia (P˃0.05).
Discussion & Conclusion: Bacterial species living in this area can be highly diverse, and therefore, in addition to other epigenetic involved factors, the studying of other factors, such as environment, nutrition, lifestyle, and the host's genetic, will increase our understanding of the pathogenesis of this complex disorder |
| first_indexed | 2024-04-13T04:45:07Z |
| format | Article |
| id | doaj.art-7816909abcb1454fbc15f0aff5b58863 |
| institution | Directory Open Access Journal |
| issn | 1563-4728 2588-3135 |
| language | fas |
| last_indexed | 2024-04-13T04:45:07Z |
| publishDate | 2022-03-01 |
| publisher | Ilam University of Medical Sciences |
| record_format | Article |
| series | Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Īlām |
| spelling | doaj.art-7816909abcb1454fbc15f0aff5b588632022-12-22T03:01:52ZfasIlam University of Medical SciencesMajallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Īlām1563-47282588-31352022-03-013018594Relationship of Bacteria Isolated from Antral Gastric Biopsy with the Incidence of Dyspepsia in Patients Referred to Mehrad and Labbafinejad Hospitals, Tehran, Iran, in 2018Mahnaz Mohammadi0Amin Talebi Bezmin Abadi1Farid Rahimi2Mojgan Forootan3 Dept of Bacteriology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran Dept of Bacteriology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran School of Biological Research, University of Canberra, Canberra, Australia Dept of Gastroenterology and Hepatology, Faculty of Medical Sciences, Shahid Beheshti University, Tehran, Iran Introduction: This descriptive cross-sectional study examined the association between the presence of four non-Helicobacter-pylori bacterial species (e.g., Staphylococcus aureus, Lactobacillus acidophilus, Pseudomonas aeruginosa, and Streptococcus sanguis) and dyspepsia. Material & Methods: This study included a total of 100 antral biopsy samples isolated from dyspeptic (n=50) or non-dyspeptic (healthy control) (n=50) patients referred to Mehrad and Labafinejad Hospitals, Tehran, Iran, in 2018. Following that, the presence of Staphylococcus aureus, Lactobacillus acidophilus, Pseudomonas aeruginosa, and Streptococcus sanguis was investigated by PCR and using their respective primers, including nuc, PA431CF, iga, and 16s rRNA. Ethics Code (IR.MODARES.REC.1397.241) . Findings: In this study, a total of 50 antral biopsies were isolated from patients with dyspepsia, and 50 antral biopsy specimens were isolated from individuals without dyspepsia during endoscopy. The mean age of the subjects was 48 years (age range: 16-80 years); moreover, the highest age group belonged to the group of 26-46 (24%) years, and the lowest age belonged to the group of 16-26 years (0.06%). The age ranges used in this study had a relatively good population distribution. According to the results of the PCR test, the prevalence rates of Staphylococcus aureus, Lactobacillus acidophilus, Pseudomonas aeruginosa, and Streptococcus sanguis in dyspeptic patients (n=50) were 23 (46%), 3 (6%), 42 (84%), and 0 (0 %), respectively. Moreover, the corresponding prevalence values were 19 (38%), 10 (20%), 45 (90%), and 2 (4%) among the non-dyspeptic control individuals. The presence of these bacteria showed no statistically significant association with the incidence of dyspepsia (P˃0.05). Discussion & Conclusion: Bacterial species living in this area can be highly diverse, and therefore, in addition to other epigenetic involved factors, the studying of other factors, such as environment, nutrition, lifestyle, and the host's genetic, will increase our understanding of the pathogenesis of this complex disorderhttp://sjimu.medilam.ac.ir/article-1-7104-en.htmlcolonizationdyspepsiagastric microbiotapseudomonas aeruginosastaphylococcus aureus |
| spellingShingle | Mahnaz Mohammadi Amin Talebi Bezmin Abadi Farid Rahimi Mojgan Forootan Relationship of Bacteria Isolated from Antral Gastric Biopsy with the Incidence of Dyspepsia in Patients Referred to Mehrad and Labbafinejad Hospitals, Tehran, Iran, in 2018 Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Īlām colonization dyspepsia gastric microbiota pseudomonas aeruginosa staphylococcus aureus |
| title | Relationship of Bacteria Isolated from Antral Gastric Biopsy with the Incidence of Dyspepsia in Patients Referred to Mehrad and Labbafinejad Hospitals, Tehran, Iran, in 2018 |
| title_full | Relationship of Bacteria Isolated from Antral Gastric Biopsy with the Incidence of Dyspepsia in Patients Referred to Mehrad and Labbafinejad Hospitals, Tehran, Iran, in 2018 |
| title_fullStr | Relationship of Bacteria Isolated from Antral Gastric Biopsy with the Incidence of Dyspepsia in Patients Referred to Mehrad and Labbafinejad Hospitals, Tehran, Iran, in 2018 |
| title_full_unstemmed | Relationship of Bacteria Isolated from Antral Gastric Biopsy with the Incidence of Dyspepsia in Patients Referred to Mehrad and Labbafinejad Hospitals, Tehran, Iran, in 2018 |
| title_short | Relationship of Bacteria Isolated from Antral Gastric Biopsy with the Incidence of Dyspepsia in Patients Referred to Mehrad and Labbafinejad Hospitals, Tehran, Iran, in 2018 |
| title_sort | relationship of bacteria isolated from antral gastric biopsy with the incidence of dyspepsia in patients referred to mehrad and labbafinejad hospitals tehran iran in 2018 |
| topic | colonization dyspepsia gastric microbiota pseudomonas aeruginosa staphylococcus aureus |
| url | http://sjimu.medilam.ac.ir/article-1-7104-en.html |
| work_keys_str_mv | AT mahnazmohammadi relationshipofbacteriaisolatedfromantralgastricbiopsywiththeincidenceofdyspepsiainpatientsreferredtomehradandlabbafinejadhospitalstehraniranin2018 AT amintalebibezminabadi relationshipofbacteriaisolatedfromantralgastricbiopsywiththeincidenceofdyspepsiainpatientsreferredtomehradandlabbafinejadhospitalstehraniranin2018 AT faridrahimi relationshipofbacteriaisolatedfromantralgastricbiopsywiththeincidenceofdyspepsiainpatientsreferredtomehradandlabbafinejadhospitalstehraniranin2018 AT mojganforootan relationshipofbacteriaisolatedfromantralgastricbiopsywiththeincidenceofdyspepsiainpatientsreferredtomehradandlabbafinejadhospitalstehraniranin2018 |