Genetic variant in microRNA-146a gene is associated with risk of rheumatoid arthritis
AbstractObjective To investigated the association between single nucleotide polymorphisms (SNPs) in microRNA-146a (miR-146a) gene and susceptibility of rheumatoid arthritis (RA).Methods We systemically extracted the genetic data of miR-146a from previous genome-wide association studies (GWASs) of RA...
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| Language: | English |
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Taylor & Francis Group
2021-01-01
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| Series: | Annals of Medicine |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/07853890.2021.1933163 |
| _version_ | 1797385699667738624 |
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| author | Lin-Lin Zhang Xiao-Xiao Wu Xu-Fan Wang Dong-Sheng Di Qian Huang Rui-Shan Liu Zong-Wen Shuai Dong-Qing Ye Rui-Xue Leng |
| author_facet | Lin-Lin Zhang Xiao-Xiao Wu Xu-Fan Wang Dong-Sheng Di Qian Huang Rui-Shan Liu Zong-Wen Shuai Dong-Qing Ye Rui-Xue Leng |
| author_sort | Lin-Lin Zhang |
| collection | DOAJ |
| description | AbstractObjective To investigated the association between single nucleotide polymorphisms (SNPs) in microRNA-146a (miR-146a) gene and susceptibility of rheumatoid arthritis (RA).Methods We systemically extracted the genetic data of miR-146a from previous genome-wide association studies (GWASs) of RA. Subsequently, we performed a replication study in an independent Chinese cohort for selected variant. A meta-analysis combined the previous GWASs with the replication study was also conducted. The epigenetic annotation and cytokine assay were used for exploring potential variant function.Results The extracted genetic association data from three previous GWASs showed that the allele T of functional SNP rs2431697 increased RA susceptibility. The significant association for the SNP was also found in the Chinese replication cohort (OR = 1.24, 95% CI = 1.06–1.46, p = 8.69E-03). The estimated effect size for this SNP was larger in Asian population than that in European population (Asian meta-analysis: OR = 1.15, 95% CI = 1.09–1.22, p = 4.37E-07; Tran-ethnic meta-analysis: OR = 1.07, 95% CI = 1.04–1.10, p = 1.79E-06). The cytokine assay also showed that the risk allele T of the SNP rs2431697 is inversely associated with plasma TNF-α levels in health controls (p = .016).Conclusions In summary, this study supports that genetic variant in miR-146a gene is associated with RA risk.KEY MESSAGESThe association between SNPs in miR-146a gene and susceptibility of RA was unclear.We investigated the genetic association using GWASs data and a replication study.The SNP rs2431697 in miR-146a gene is associated with RA risk. |
| first_indexed | 2024-03-08T21:58:04Z |
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| id | doaj.art-7816e6216e094ba7a122f6bbbe8e1e23 |
| institution | Directory Open Access Journal |
| issn | 0785-3890 1365-2060 |
| language | English |
| last_indexed | 2024-03-08T21:58:04Z |
| publishDate | 2021-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Annals of Medicine |
| spelling | doaj.art-7816e6216e094ba7a122f6bbbe8e1e232023-12-19T16:46:27ZengTaylor & Francis GroupAnnals of Medicine0785-38901365-20602021-01-0153182482910.1080/07853890.2021.1933163Genetic variant in microRNA-146a gene is associated with risk of rheumatoid arthritisLin-Lin Zhang0Xiao-Xiao Wu1Xu-Fan Wang2Dong-Sheng Di3Qian Huang4Rui-Shan Liu5Zong-Wen Shuai6Dong-Qing Ye7Rui-Xue Leng8Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, PR ChinaDepartment of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, PR ChinaDepartment of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, PR ChinaDepartment of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, PR ChinaDepartment of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, PR ChinaDepartment of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, PR ChinaDepartment of Rheumatology and Immunology, the First Affiliated Hospital of Anhui Medical University, Hefei, PR ChinaDepartment of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, PR ChinaDepartment of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, PR ChinaAbstractObjective To investigated the association between single nucleotide polymorphisms (SNPs) in microRNA-146a (miR-146a) gene and susceptibility of rheumatoid arthritis (RA).Methods We systemically extracted the genetic data of miR-146a from previous genome-wide association studies (GWASs) of RA. Subsequently, we performed a replication study in an independent Chinese cohort for selected variant. A meta-analysis combined the previous GWASs with the replication study was also conducted. The epigenetic annotation and cytokine assay were used for exploring potential variant function.Results The extracted genetic association data from three previous GWASs showed that the allele T of functional SNP rs2431697 increased RA susceptibility. The significant association for the SNP was also found in the Chinese replication cohort (OR = 1.24, 95% CI = 1.06–1.46, p = 8.69E-03). The estimated effect size for this SNP was larger in Asian population than that in European population (Asian meta-analysis: OR = 1.15, 95% CI = 1.09–1.22, p = 4.37E-07; Tran-ethnic meta-analysis: OR = 1.07, 95% CI = 1.04–1.10, p = 1.79E-06). The cytokine assay also showed that the risk allele T of the SNP rs2431697 is inversely associated with plasma TNF-α levels in health controls (p = .016).Conclusions In summary, this study supports that genetic variant in miR-146a gene is associated with RA risk.KEY MESSAGESThe association between SNPs in miR-146a gene and susceptibility of RA was unclear.We investigated the genetic association using GWASs data and a replication study.The SNP rs2431697 in miR-146a gene is associated with RA risk.https://www.tandfonline.com/doi/10.1080/07853890.2021.1933163MiR-146asingle nucleotide polymorphismssusceptibilityrheumatoid arthritiscytokine |
| spellingShingle | Lin-Lin Zhang Xiao-Xiao Wu Xu-Fan Wang Dong-Sheng Di Qian Huang Rui-Shan Liu Zong-Wen Shuai Dong-Qing Ye Rui-Xue Leng Genetic variant in microRNA-146a gene is associated with risk of rheumatoid arthritis Annals of Medicine MiR-146a single nucleotide polymorphisms susceptibility rheumatoid arthritis cytokine |
| title | Genetic variant in microRNA-146a gene is associated with risk of rheumatoid arthritis |
| title_full | Genetic variant in microRNA-146a gene is associated with risk of rheumatoid arthritis |
| title_fullStr | Genetic variant in microRNA-146a gene is associated with risk of rheumatoid arthritis |
| title_full_unstemmed | Genetic variant in microRNA-146a gene is associated with risk of rheumatoid arthritis |
| title_short | Genetic variant in microRNA-146a gene is associated with risk of rheumatoid arthritis |
| title_sort | genetic variant in microrna 146a gene is associated with risk of rheumatoid arthritis |
| topic | MiR-146a single nucleotide polymorphisms susceptibility rheumatoid arthritis cytokine |
| url | https://www.tandfonline.com/doi/10.1080/07853890.2021.1933163 |
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