Prevalence of prediabetes by the fasting plasma glucose and HbA1c screening criteria among the children and adolescents of Shenzhen, China
BackgroundPrediabetes is associated with an increased risk of cardiovascular diseases and all-cause mortality. Rare research in China has evaluated the prevalence of prediabetes among children and adolescents using the HbA1c criterion or the combined FPG-or-HbA1c diagnostic criterion, and researcher...
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Frontiers Media S.A.
2024-01-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2024.1301921/full |
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| author | Chen Yang Chen Yang Shaohua Li Liangyan Wu Zan Ding Hua Zhou Ying Pan Chufu Yang Jinjun Lin Qiang Li Yingbin You Xu Zhong Yuyuan Chen Yu Zhao |
| author_facet | Chen Yang Chen Yang Shaohua Li Liangyan Wu Zan Ding Hua Zhou Ying Pan Chufu Yang Jinjun Lin Qiang Li Yingbin You Xu Zhong Yuyuan Chen Yu Zhao |
| author_sort | Chen Yang |
| collection | DOAJ |
| description | BackgroundPrediabetes is associated with an increased risk of cardiovascular diseases and all-cause mortality. Rare research in China has evaluated the prevalence of prediabetes among children and adolescents using the HbA1c criterion or the combined FPG-or-HbA1c diagnostic criterion, and researchers paid no attention to the distributions of blood glucose in Shenzhen, especially for juveniles.MethodsWe conducted a school-based cross-sectional study based on the first-year students from 17 primary, middle, and high schools. Prediabetes was defined as FPG of 5.6–6.9 mmol/L or HbA1c of 5.7%–6.4%. The crude and standardized prevalence of prediabetes with 95% confidence interval (95% CI) was estimated.ResultsA total of 7519 participants, aged 6 to 17 years, were included. For all subjects, the crude prevalence (95% CI) of prediabetes was 1.49% (1.21–1.77), 8.72% (8.08–9.36), and 9.80% (9.13–10.47) by the FPG-only, HbA1c-only, and FPG-or-HbA1c criteria, respectively. Based on the 2010 Shenzhen census population, the standardized prevalence was 1.56% (males 1.85%, females 1.19%), 11.05% (males 11.47%, females 10.53%), and 12.19% (males 13.01%, females 11.15%) by the corresponding criteria. The proportion of prediabetes was higher for males than females, and the prevalence decreased with grade for males but increased for females. The association of BMI and prediabetes was U-shaped curve, indicating higher rates of prediabetes for underweight and obesity people.ConclusionThe blood glucose status of children and adolescents in Shenzhen is worrisome, and the early detection and management of prediabetes are imperative. |
| first_indexed | 2024-03-08T12:56:19Z |
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| id | doaj.art-7818662a8e1b419cb9557beff590dd84 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-03-08T12:56:19Z |
| publishDate | 2024-01-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Endocrinology |
| spelling | doaj.art-7818662a8e1b419cb9557beff590dd842024-01-19T17:10:54ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922024-01-011510.3389/fendo.2024.13019211301921Prevalence of prediabetes by the fasting plasma glucose and HbA1c screening criteria among the children and adolescents of Shenzhen, ChinaChen Yang0Chen Yang1Shaohua Li2Liangyan Wu3Zan Ding4Hua Zhou5Ying Pan6Chufu Yang7Jinjun Lin8Qiang Li9Yingbin You10Xu Zhong11Yuyuan Chen12Yu Zhao13Department of Endocrinology, Baoan Central Hospital of Shenzhen, The 5th Affiliated Hospital of Shenzhen University Health Science Center, Shenzhen, Guangdong, ChinaDepartment of Endocrinology and Metabolism, Zhuhai People's Hospital (Zhuhai Clinical Medical College of Jinan University), Zhuhai, Guangdong, ChinaWards of Cadres, Zhuhai People's Hospital (Zhuhai Clinical Medical College of Jinan University), Zhuhai, Guangdong, ChinaDepartment of Endocrinology and Metabolism, The First Affiliated Hospital of Jinan University, Guangzhou, ChinaDepartment of Science and Education, Baoan Central Hospital of Shenzhen, Shenzhen, Guangdong, ChinaDepartment of Administrative, Baoan Central Hospital of Shenzhen, Shenzhen, Guangdong, ChinaDepartment of Endocrinology, Baoan Central Hospital of Shenzhen, The 5th Affiliated Hospital of Shenzhen University Health Science Center, Shenzhen, Guangdong, ChinaDepartment of Huangtian Outpatient, Baoan Central Hospital of Shenzhen, Shenzhen, Guangdong, ChinaDepartment of Endocrinology, Baoan Central Hospital of Shenzhen, The 5th Affiliated Hospital of Shenzhen University Health Science Center, Shenzhen, Guangdong, ChinaDepartment of Endocrinology, Shenzhen University General Hospital, Shenzhen, Guangdong, ChinaDepartment of Administrative, Baoan Central Hospital of Shenzhen, Shenzhen, Guangdong, ChinaDepartment of Endocrinology, Baoan Central Hospital of Shenzhen, The 5th Affiliated Hospital of Shenzhen University Health Science Center, Shenzhen, Guangdong, ChinaDepartment of Endocrinology, Baoan Central Hospital of Shenzhen, The 5th Affiliated Hospital of Shenzhen University Health Science Center, Shenzhen, Guangdong, ChinaDepartment of Endocrinology, Baoan Central Hospital of Shenzhen, The 5th Affiliated Hospital of Shenzhen University Health Science Center, Shenzhen, Guangdong, ChinaBackgroundPrediabetes is associated with an increased risk of cardiovascular diseases and all-cause mortality. Rare research in China has evaluated the prevalence of prediabetes among children and adolescents using the HbA1c criterion or the combined FPG-or-HbA1c diagnostic criterion, and researchers paid no attention to the distributions of blood glucose in Shenzhen, especially for juveniles.MethodsWe conducted a school-based cross-sectional study based on the first-year students from 17 primary, middle, and high schools. Prediabetes was defined as FPG of 5.6–6.9 mmol/L or HbA1c of 5.7%–6.4%. The crude and standardized prevalence of prediabetes with 95% confidence interval (95% CI) was estimated.ResultsA total of 7519 participants, aged 6 to 17 years, were included. For all subjects, the crude prevalence (95% CI) of prediabetes was 1.49% (1.21–1.77), 8.72% (8.08–9.36), and 9.80% (9.13–10.47) by the FPG-only, HbA1c-only, and FPG-or-HbA1c criteria, respectively. Based on the 2010 Shenzhen census population, the standardized prevalence was 1.56% (males 1.85%, females 1.19%), 11.05% (males 11.47%, females 10.53%), and 12.19% (males 13.01%, females 11.15%) by the corresponding criteria. The proportion of prediabetes was higher for males than females, and the prevalence decreased with grade for males but increased for females. The association of BMI and prediabetes was U-shaped curve, indicating higher rates of prediabetes for underweight and obesity people.ConclusionThe blood glucose status of children and adolescents in Shenzhen is worrisome, and the early detection and management of prediabetes are imperative.https://www.frontiersin.org/articles/10.3389/fendo.2024.1301921/fulladolescentschildrenprediabetesprevalenceShenzhen |
| spellingShingle | Chen Yang Chen Yang Shaohua Li Liangyan Wu Zan Ding Hua Zhou Ying Pan Chufu Yang Jinjun Lin Qiang Li Yingbin You Xu Zhong Yuyuan Chen Yu Zhao Prevalence of prediabetes by the fasting plasma glucose and HbA1c screening criteria among the children and adolescents of Shenzhen, China Frontiers in Endocrinology adolescents children prediabetes prevalence Shenzhen |
| title | Prevalence of prediabetes by the fasting plasma glucose and HbA1c screening criteria among the children and adolescents of Shenzhen, China |
| title_full | Prevalence of prediabetes by the fasting plasma glucose and HbA1c screening criteria among the children and adolescents of Shenzhen, China |
| title_fullStr | Prevalence of prediabetes by the fasting plasma glucose and HbA1c screening criteria among the children and adolescents of Shenzhen, China |
| title_full_unstemmed | Prevalence of prediabetes by the fasting plasma glucose and HbA1c screening criteria among the children and adolescents of Shenzhen, China |
| title_short | Prevalence of prediabetes by the fasting plasma glucose and HbA1c screening criteria among the children and adolescents of Shenzhen, China |
| title_sort | prevalence of prediabetes by the fasting plasma glucose and hba1c screening criteria among the children and adolescents of shenzhen china |
| topic | adolescents children prediabetes prevalence Shenzhen |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2024.1301921/full |
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