Quantitative EEG and medial temporal lobe atrophy in Alzheimer′s dementia: Preliminary study
Backgrounds: The electroencephalogram (EEG) abnormalities in Alzheimer′s disease (AD) have been widely reported, and medial temporal lobe atrophy (MTLA) is one of the hallmarks in early stage of AD. We aimed to assess the relationship between EEG abnormalities and MTLA and its clinical validity. Mat...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2015-01-01
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| Series: | Annals of Indian Academy of Neurology |
| Subjects: | |
| Online Access: | http://www.annalsofian.org/article.asp?issn=0972-2327;year=2015;volume=18;issue=1;spage=10;epage=14;aulast=Lee |
| _version_ | 1818279944214544384 |
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| author | Soo-Ji Lee Min-Ho Park Sang-Soon Park Jin-Young Ahn Jae-Hyeok Heo |
| author_facet | Soo-Ji Lee Min-Ho Park Sang-Soon Park Jin-Young Ahn Jae-Hyeok Heo |
| author_sort | Soo-Ji Lee |
| collection | DOAJ |
| description | Backgrounds: The electroencephalogram (EEG) abnormalities in Alzheimer′s disease (AD) have been widely reported, and medial temporal lobe atrophy (MTLA) is one of the hallmarks in early stage of AD. We aimed to assess the relationship between EEG abnormalities and MTLA and its clinical validity. Materials and Methods: A total of 18 patients with AD were recruited (the mean age: 77.83 years). Baseline EEGs were analyzed with quantitative spectral analysis. MTLA was assessed by a T1-axial visual rating scale (VRS). Results: In relative power spectrum analysis according to the right MTLA severity, the power of theta waves in C4, T4, F4, F8, and T5 increased significantly and the power of beta waves in T6, C4, T4, F8, T5, P3, T3, and F7 decreased significantly in severe atrophy group. In relative power spectrum analysis according to the left MTLA severity, the power of theta waves in T3 increased significantly and that of beta waves in P4, T6, C4, F4, F8, T5, P3, C3, T3, F3, and F7 decreased significantly in severe atrophy group. Conclusion: The severe MTLA group, regardless of laterality, showed more severe quantitative EEG alterations. These results suggest that quantitative EEG abnormalities are correlated with the MTLA, which may play an important role in AD process. |
| first_indexed | 2024-12-12T23:41:22Z |
| format | Article |
| id | doaj.art-781985365a3840a1a5f5ff0c8ff613b5 |
| institution | Directory Open Access Journal |
| issn | 0972-2327 1998-3549 |
| language | English |
| last_indexed | 2024-12-12T23:41:22Z |
| publishDate | 2015-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Annals of Indian Academy of Neurology |
| spelling | doaj.art-781985365a3840a1a5f5ff0c8ff613b52022-12-22T00:07:08ZengWolters Kluwer Medknow PublicationsAnnals of Indian Academy of Neurology0972-23271998-35492015-01-01181101410.4103/0972-2327.145284Quantitative EEG and medial temporal lobe atrophy in Alzheimer′s dementia: Preliminary studySoo-Ji LeeMin-Ho ParkSang-Soon ParkJin-Young AhnJae-Hyeok HeoBackgrounds: The electroencephalogram (EEG) abnormalities in Alzheimer′s disease (AD) have been widely reported, and medial temporal lobe atrophy (MTLA) is one of the hallmarks in early stage of AD. We aimed to assess the relationship between EEG abnormalities and MTLA and its clinical validity. Materials and Methods: A total of 18 patients with AD were recruited (the mean age: 77.83 years). Baseline EEGs were analyzed with quantitative spectral analysis. MTLA was assessed by a T1-axial visual rating scale (VRS). Results: In relative power spectrum analysis according to the right MTLA severity, the power of theta waves in C4, T4, F4, F8, and T5 increased significantly and the power of beta waves in T6, C4, T4, F8, T5, P3, T3, and F7 decreased significantly in severe atrophy group. In relative power spectrum analysis according to the left MTLA severity, the power of theta waves in T3 increased significantly and that of beta waves in P4, T6, C4, F4, F8, T5, P3, C3, T3, F3, and F7 decreased significantly in severe atrophy group. Conclusion: The severe MTLA group, regardless of laterality, showed more severe quantitative EEG alterations. These results suggest that quantitative EEG abnormalities are correlated with the MTLA, which may play an important role in AD process.http://www.annalsofian.org/article.asp?issn=0972-2327;year=2015;volume=18;issue=1;spage=10;epage=14;aulast=LeeAlzheimer′s diseasemedial temporal lobe atrophyquantitative EEG |
| spellingShingle | Soo-Ji Lee Min-Ho Park Sang-Soon Park Jin-Young Ahn Jae-Hyeok Heo Quantitative EEG and medial temporal lobe atrophy in Alzheimer′s dementia: Preliminary study Annals of Indian Academy of Neurology Alzheimer′s disease medial temporal lobe atrophy quantitative EEG |
| title | Quantitative EEG and medial temporal lobe atrophy in Alzheimer′s dementia: Preliminary study |
| title_full | Quantitative EEG and medial temporal lobe atrophy in Alzheimer′s dementia: Preliminary study |
| title_fullStr | Quantitative EEG and medial temporal lobe atrophy in Alzheimer′s dementia: Preliminary study |
| title_full_unstemmed | Quantitative EEG and medial temporal lobe atrophy in Alzheimer′s dementia: Preliminary study |
| title_short | Quantitative EEG and medial temporal lobe atrophy in Alzheimer′s dementia: Preliminary study |
| title_sort | quantitative eeg and medial temporal lobe atrophy in alzheimer s dementia preliminary study |
| topic | Alzheimer′s disease medial temporal lobe atrophy quantitative EEG |
| url | http://www.annalsofian.org/article.asp?issn=0972-2327;year=2015;volume=18;issue=1;spage=10;epage=14;aulast=Lee |
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