Bioavailability of Polyphenol Liposomes: A Challenge Ahead
Dietary polyphenols, including flavonoids, have long been recognized as a source of important molecules involved in the prevention of several diseases, including cancer. However, because of their poor bioavailability, polyphenols remain difficult to be employed clinically. Over the past few years, a...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2013-09-01
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| Series: | Pharmaceutics |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1999-4923/5/3/457 |
| _version_ | 1828352918300917760 |
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| author | Guy G. Chabot Nathalie Mignet Johanne Seguin |
| author_facet | Guy G. Chabot Nathalie Mignet Johanne Seguin |
| author_sort | Guy G. Chabot |
| collection | DOAJ |
| description | Dietary polyphenols, including flavonoids, have long been recognized as a source of important molecules involved in the prevention of several diseases, including cancer. However, because of their poor bioavailability, polyphenols remain difficult to be employed clinically. Over the past few years, a renewed interest has been devoted to the use of liposomes as carriers aimed at increasing the bioavailability and, hence, the therapeutic benefits of polyphenols. In this paper, we review the causes of the poor bioavailability of polyphenols and concentrate on their liposomal formulations, which offer a means of improving their pharmacokinetics and pharmacodynamics. The problems linked to their development and their potential therapeutic advantages are reviewed. Future directions for liposomal polyphenol development are suggested. |
| first_indexed | 2024-04-14T02:01:38Z |
| format | Article |
| id | doaj.art-781c5ca4610744cea334520eba06ac43 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-04-14T02:01:38Z |
| publishDate | 2013-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-781c5ca4610744cea334520eba06ac432022-12-22T02:18:50ZengMDPI AGPharmaceutics1999-49232013-09-015345747110.3390/pharmaceutics5030457Bioavailability of Polyphenol Liposomes: A Challenge AheadGuy G. ChabotNathalie MignetJohanne SeguinDietary polyphenols, including flavonoids, have long been recognized as a source of important molecules involved in the prevention of several diseases, including cancer. However, because of their poor bioavailability, polyphenols remain difficult to be employed clinically. Over the past few years, a renewed interest has been devoted to the use of liposomes as carriers aimed at increasing the bioavailability and, hence, the therapeutic benefits of polyphenols. In this paper, we review the causes of the poor bioavailability of polyphenols and concentrate on their liposomal formulations, which offer a means of improving their pharmacokinetics and pharmacodynamics. The problems linked to their development and their potential therapeutic advantages are reviewed. Future directions for liposomal polyphenol development are suggested.http://www.mdpi.com/1999-4923/5/3/457polyphenolsflavonoidsliposomeslipid polyphenol interactionbioavailability |
| spellingShingle | Guy G. Chabot Nathalie Mignet Johanne Seguin Bioavailability of Polyphenol Liposomes: A Challenge Ahead Pharmaceutics polyphenols flavonoids liposomes lipid polyphenol interaction bioavailability |
| title | Bioavailability of Polyphenol Liposomes: A Challenge Ahead |
| title_full | Bioavailability of Polyphenol Liposomes: A Challenge Ahead |
| title_fullStr | Bioavailability of Polyphenol Liposomes: A Challenge Ahead |
| title_full_unstemmed | Bioavailability of Polyphenol Liposomes: A Challenge Ahead |
| title_short | Bioavailability of Polyphenol Liposomes: A Challenge Ahead |
| title_sort | bioavailability of polyphenol liposomes a challenge ahead |
| topic | polyphenols flavonoids liposomes lipid polyphenol interaction bioavailability |
| url | http://www.mdpi.com/1999-4923/5/3/457 |
| work_keys_str_mv | AT guygchabot bioavailabilityofpolyphenolliposomesachallengeahead AT nathaliemignet bioavailabilityofpolyphenolliposomesachallengeahead AT johanneseguin bioavailabilityofpolyphenolliposomesachallengeahead |