Evaluation of a Common Internal Standard Material to Reduce Inter-Laboratory Variation and Ensure the Quality, Safety and Efficacy of Expanded Newborn Screening Results When Using Flow Injection Analysis Tandem Mass Spectrometry with Internal Calibration

Evaluation of a Common Internal Standard Material to Reduce Inter-Laboratory Variation and Ensure the Quality, Safety and Efficacy of Expanded Newborn Screening Results When Using Flow Injection Analysis Tandem Mass Spectrometry with Internal Calibration

In 2015, the newborn screening (NBS) programmes in England and Wales were expanded to include four additional disorders: Classical Homocystinuria, Isovaleric Acidemia, Glutaric Aciduria Type 1 and Maple Syrup Urine Disease, bringing the total number of analytes quantified to eight: phenylalanine, ty...

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Bibliographic Details
Main Authors: Rachel S. Carling, Catharine John, Philippa Goddard, Caroline Griffith, Simon Cowen, Christopher Hopley, Stuart J. Moat
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:International Journal of Neonatal Screening
Subjects:
expanded screening
internal calibration
flow injection analysis tandem mass spectrometry
dried blood spots
inter-laboratory variation
isotope dilution
Online Access:https://www.mdpi.com/2409-515X/6/4/92

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