Epilepsy phenotype and response to KCNQ openers in mice harboring the Kcnq2 R207W voltage-sensor mutation

Epilepsy phenotype and response to KCNQ openers in mice harboring the Kcnq2 R207W voltage-sensor mutation

KCNQ2-encoded Kv7.2 subunits play a critical role in balancing neuronal excitability. Mutations in KCNQ2 are responsible for highly-heterogenous epileptic and neurodevelopmental phenotypes ranging from self-limited familial neonatal epilepsy (SeLFNE) to severe developmental and epileptic encephalopa...

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Bibliographic Details
Main Authors: Fuyun Tian, Birong Cao, Haiyan Xu, Li Zhan, Fajun Nan, Ning Li, Maurizio Taglialatela, Zhaobing Gao
Format: Article
Language:English
Published: Elsevier 2022-11-01
Series:Neurobiology of Disease
Subjects:
KCNQ2
Epilepsy
Mouse model
HN37 (pynegabine)
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996122002522

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