Beta-Thalassemia Minor and SARS-CoV-2: Physiopathology, Prevalence, Severity, Morbidity, and Mortality
Background: Since the first year of the COVID-19 global pandemic, a hypothesis concerning the possible protection/immunity of beta-thalassemia carriers has remained in abeyance. Methods: Three databases (Pubmed Central, Scopus, and Google Scholar) were screened and checked in order to extract all st...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-01-01
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| Series: | Thalassemia Reports |
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| Online Access: | https://www.mdpi.com/2039-4365/13/1/3 |
| _version_ | 1797608851466354688 |
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| author | Edouard Lansiaux Emmanuel Drouin Carsten Bolm |
| author_facet | Edouard Lansiaux Emmanuel Drouin Carsten Bolm |
| author_sort | Edouard Lansiaux |
| collection | DOAJ |
| description | Background: Since the first year of the COVID-19 global pandemic, a hypothesis concerning the possible protection/immunity of beta-thalassemia carriers has remained in abeyance. Methods: Three databases (Pubmed Central, Scopus, and Google Scholar) were screened and checked in order to extract all studies about the incidence of confirmed COVID-19 cases, mortality rate, severity assessment, or ICU admission among patients with beta-thalassemia minor, were included in this analysis. The language was limited to English. Studies such as case reports, review studies, and studies that did not have complete data for calculating incidences were excluded. Results and discussion: a total of 3 studies out of 2265 were selected. According to our systematic-review meta-analysis, beta-thalassemia carriers could be less affected by COVID-19 than the general population [IRR = 0.9250 (0.5752; 1.4877)], affected by COVID-19 with a worst severity [OR = 1.5933 (0.4884; 5.1981)], less admissible into the ICU [IRR = 0.3620 (0.0025; 51.6821)], and more susceptible to die from COVID-19 or one of its consequences [IRR = 1.8542 (0.7819; 4.3970)]. However, all of those results remain insignificant with a bad <i>p</i>-value (respectively 0.7479, 0.4400, 0.6881, and 0.1610). Other large case-control or registry studies are needed to confirm these trends. |
| first_indexed | 2024-03-11T05:49:20Z |
| format | Article |
| id | doaj.art-781cfc5911424b56be372c9c1e42bbfd |
| institution | Directory Open Access Journal |
| issn | 2039-4365 |
| language | English |
| last_indexed | 2024-03-11T05:49:20Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Thalassemia Reports |
| spelling | doaj.art-781cfc5911424b56be372c9c1e42bbfd2023-11-17T14:12:05ZengMDPI AGThalassemia Reports2039-43652023-01-01131213210.3390/thalassrep13010003Beta-Thalassemia Minor and SARS-CoV-2: Physiopathology, Prevalence, Severity, Morbidity, and MortalityEdouard Lansiaux0Emmanuel Drouin1Carsten Bolm2Henry Warembourg School of Medicine, Lille University, 2 Avenue Eugène Avinée, 59120 Loos, FranceNeurology Service, Lille Catholic Institute Hospital Group, GHICL (Groupe Hospitalier de l’Institut Catholique de Lille), 115 Rue du Grand But, 59462 Lomme, FranceInstitute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, D-52074 Aachen, GermanyBackground: Since the first year of the COVID-19 global pandemic, a hypothesis concerning the possible protection/immunity of beta-thalassemia carriers has remained in abeyance. Methods: Three databases (Pubmed Central, Scopus, and Google Scholar) were screened and checked in order to extract all studies about the incidence of confirmed COVID-19 cases, mortality rate, severity assessment, or ICU admission among patients with beta-thalassemia minor, were included in this analysis. The language was limited to English. Studies such as case reports, review studies, and studies that did not have complete data for calculating incidences were excluded. Results and discussion: a total of 3 studies out of 2265 were selected. According to our systematic-review meta-analysis, beta-thalassemia carriers could be less affected by COVID-19 than the general population [IRR = 0.9250 (0.5752; 1.4877)], affected by COVID-19 with a worst severity [OR = 1.5933 (0.4884; 5.1981)], less admissible into the ICU [IRR = 0.3620 (0.0025; 51.6821)], and more susceptible to die from COVID-19 or one of its consequences [IRR = 1.8542 (0.7819; 4.3970)]. However, all of those results remain insignificant with a bad <i>p</i>-value (respectively 0.7479, 0.4400, 0.6881, and 0.1610). Other large case-control or registry studies are needed to confirm these trends.https://www.mdpi.com/2039-4365/13/1/3COVID-19SARS-CoV-2respiratory distressbeta thalassemiaminorimmunization |
| spellingShingle | Edouard Lansiaux Emmanuel Drouin Carsten Bolm Beta-Thalassemia Minor and SARS-CoV-2: Physiopathology, Prevalence, Severity, Morbidity, and Mortality Thalassemia Reports COVID-19 SARS-CoV-2 respiratory distress beta thalassemia minor immunization |
| title | Beta-Thalassemia Minor and SARS-CoV-2: Physiopathology, Prevalence, Severity, Morbidity, and Mortality |
| title_full | Beta-Thalassemia Minor and SARS-CoV-2: Physiopathology, Prevalence, Severity, Morbidity, and Mortality |
| title_fullStr | Beta-Thalassemia Minor and SARS-CoV-2: Physiopathology, Prevalence, Severity, Morbidity, and Mortality |
| title_full_unstemmed | Beta-Thalassemia Minor and SARS-CoV-2: Physiopathology, Prevalence, Severity, Morbidity, and Mortality |
| title_short | Beta-Thalassemia Minor and SARS-CoV-2: Physiopathology, Prevalence, Severity, Morbidity, and Mortality |
| title_sort | beta thalassemia minor and sars cov 2 physiopathology prevalence severity morbidity and mortality |
| topic | COVID-19 SARS-CoV-2 respiratory distress beta thalassemia minor immunization |
| url | https://www.mdpi.com/2039-4365/13/1/3 |
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