The effect of magnesium supplementation and weight loss on liver enzymes in patients with nonalcoholic fatty liver disease

Background: There have been few studies to examine the effect of magnesium (Mg) supplementation on liver enzymes. The aim of this study was to evaluate the effect of Mg supplementation and weight loss on liver enzymes, lipid profile, and fasting blood sugar in patients with nonalcoholic fatty liver...

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Main Authors: Majid Karandish, Mahtab Tamimi, Ali Akbar Shayesteh, Mohammad Hosein Haghighizadeh, Mohammad Taha Jalali
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2013-01-01
Series:Journal of Research in Medical Sciences
Subjects:
Online Access:http://www.jmsjournal.net/article.asp?issn=1735-1995;year=2013;volume=18;issue=7;spage=573;epage=579;aulast=Karandish
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author Majid Karandish
Mahtab Tamimi
Ali Akbar Shayesteh
Mohammad Hosein Haghighizadeh
Mohammad Taha Jalali
author_facet Majid Karandish
Mahtab Tamimi
Ali Akbar Shayesteh
Mohammad Hosein Haghighizadeh
Mohammad Taha Jalali
author_sort Majid Karandish
collection DOAJ
description Background: There have been few studies to examine the effect of magnesium (Mg) supplementation on liver enzymes. The aim of this study was to evaluate the effect of Mg supplementation and weight loss on liver enzymes, lipid profile, and fasting blood sugar in patients with nonalcoholic fatty liver disease (NAFLD). Materials and Methods: This study was a double-blind, placebo-controlled, randomized clinical trial. Ultrasonography was used to diagnose fatty liver in patients with alanine aminotransferase (ALT) ≥ 40 U/L and without other hepatic diseases. A total of 68 participants (18-59 years) with NAFLD were randomly divided into two groups to receive either Mg supplement (350 mg elemental Mg per day) or placebo for 90 days. At baseline and at the end of the intervention serum ALT, aspartate aminotransferase (AST), alkaline phosphatase (ALP), total cholesterol (TCHO), high-density lipoprotein cholesterol (HDL-C), triglyceride (TG), blood sugar and serum insulin, and Mg levels were measured in fasting state. Low-density lipoprotein cholesterol (LDL-C) and insulin resistance (IR) were calculated using Friedewald formula and homeostasis model assessment of insulin resistance (HOMA-IR), respectively. All participants received lifestyle recommendations including low calorie diet and physical activity. Results: Significant decreases within the intervention and placebo groups were observed in ALT (57.00 (25) to 41.82 ± 19.40 U/L, P = 0.000; 68.50 ± 26.96 to 40.17 ± 19.40 U/L, P = 0.000 in Mg and placebo groups, respectively). Similar significant decreases were observed in AST and fasting serum insulin within the study groups. The decrease in weight was also significant in both groups (91.05 ± 13.77 to 87.60 ± 14.37 kg and 94.59 ± 16.85 to 91.45 ± 16.39 kg in Mg and placebo groups, respectively). LDL-C and TCHO were decreased significantly in placebo group but not in the intervention group. Serum Mg was increased significantly in the intervention group. No statistically significant differences were observed between the two study groups at baseline and after intervention. Conclusion: According to the findings of this study, Mg supplement does not affect liver enzymes but weight loss may have an important role in improving fatty liver disease.
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spelling doaj.art-781d4b21eef94315a74ddc7afbd5ca242022-12-21T22:21:02ZengWolters Kluwer Medknow PublicationsJournal of Research in Medical Sciences1735-19951735-71362013-01-01187573579The effect of magnesium supplementation and weight loss on liver enzymes in patients with nonalcoholic fatty liver diseaseMajid KarandishMahtab TamimiAli Akbar ShayestehMohammad Hosein HaghighizadehMohammad Taha JalaliBackground: There have been few studies to examine the effect of magnesium (Mg) supplementation on liver enzymes. The aim of this study was to evaluate the effect of Mg supplementation and weight loss on liver enzymes, lipid profile, and fasting blood sugar in patients with nonalcoholic fatty liver disease (NAFLD). Materials and Methods: This study was a double-blind, placebo-controlled, randomized clinical trial. Ultrasonography was used to diagnose fatty liver in patients with alanine aminotransferase (ALT) ≥ 40 U/L and without other hepatic diseases. A total of 68 participants (18-59 years) with NAFLD were randomly divided into two groups to receive either Mg supplement (350 mg elemental Mg per day) or placebo for 90 days. At baseline and at the end of the intervention serum ALT, aspartate aminotransferase (AST), alkaline phosphatase (ALP), total cholesterol (TCHO), high-density lipoprotein cholesterol (HDL-C), triglyceride (TG), blood sugar and serum insulin, and Mg levels were measured in fasting state. Low-density lipoprotein cholesterol (LDL-C) and insulin resistance (IR) were calculated using Friedewald formula and homeostasis model assessment of insulin resistance (HOMA-IR), respectively. All participants received lifestyle recommendations including low calorie diet and physical activity. Results: Significant decreases within the intervention and placebo groups were observed in ALT (57.00 (25) to 41.82 ± 19.40 U/L, P = 0.000; 68.50 ± 26.96 to 40.17 ± 19.40 U/L, P = 0.000 in Mg and placebo groups, respectively). Similar significant decreases were observed in AST and fasting serum insulin within the study groups. The decrease in weight was also significant in both groups (91.05 ± 13.77 to 87.60 ± 14.37 kg and 94.59 ± 16.85 to 91.45 ± 16.39 kg in Mg and placebo groups, respectively). LDL-C and TCHO were decreased significantly in placebo group but not in the intervention group. Serum Mg was increased significantly in the intervention group. No statistically significant differences were observed between the two study groups at baseline and after intervention. Conclusion: According to the findings of this study, Mg supplement does not affect liver enzymes but weight loss may have an important role in improving fatty liver disease.http://www.jmsjournal.net/article.asp?issn=1735-1995;year=2013;volume=18;issue=7;spage=573;epage=579;aulast=KarandishAlanine aminotransferaseaspartate aminotransferaseinsulinmagnesiumnonalcoholic fatty liver disease
spellingShingle Majid Karandish
Mahtab Tamimi
Ali Akbar Shayesteh
Mohammad Hosein Haghighizadeh
Mohammad Taha Jalali
The effect of magnesium supplementation and weight loss on liver enzymes in patients with nonalcoholic fatty liver disease
Journal of Research in Medical Sciences
Alanine aminotransferase
aspartate aminotransferase
insulin
magnesium
nonalcoholic fatty liver disease
title The effect of magnesium supplementation and weight loss on liver enzymes in patients with nonalcoholic fatty liver disease
title_full The effect of magnesium supplementation and weight loss on liver enzymes in patients with nonalcoholic fatty liver disease
title_fullStr The effect of magnesium supplementation and weight loss on liver enzymes in patients with nonalcoholic fatty liver disease
title_full_unstemmed The effect of magnesium supplementation and weight loss on liver enzymes in patients with nonalcoholic fatty liver disease
title_short The effect of magnesium supplementation and weight loss on liver enzymes in patients with nonalcoholic fatty liver disease
title_sort effect of magnesium supplementation and weight loss on liver enzymes in patients with nonalcoholic fatty liver disease
topic Alanine aminotransferase
aspartate aminotransferase
insulin
magnesium
nonalcoholic fatty liver disease
url http://www.jmsjournal.net/article.asp?issn=1735-1995;year=2013;volume=18;issue=7;spage=573;epage=579;aulast=Karandish
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