LncRNA CRNDE attenuates chemoresistance in gastric cancer via SRSF6-regulated alternative splicing of PICALM

LncRNA CRNDE attenuates chemoresistance in gastric cancer via SRSF6-regulated alternative splicing of PICALM

Abstract De novo and acquired resistance, which are mainly mediated by genetic alterations, are barriers to effective routine chemotherapy. However, the mechanisms underlying gastric cancer (GC) resistance to chemotherapy are still unclear. We showed that the long noncoding RNA CRNDE was related to...

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Bibliographic Details
Main Authors: Feifei Zhang, Hui Wang, Jiang Yu, Xueqing Yao, Shibin Yang, Weidong Li, Lijun Xu, Liang Zhao
Format: Article
Language:English
Published: BMC 2021-01-01
Series:Molecular Cancer
Subjects:
Gastric cancer
Long noncoding RNA CRNDE
Chemoresistant
Autophagy
Protein splicing
Online Access:https://doi.org/10.1186/s12943-020-01299-y

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