The ERK MAP kinase-PEA3/ETV4-MMP-1 axis is operative in oesophageal adenocarcinoma
<p>Abstract</p> <p>Background</p> <p>Many members of the ETS-domain transcription factor family are important drivers of tumourigenesis. In this context, their activation by Ras-ERK pathway signaling is particularly relevant to the tumourigenic properties of many ETS-do...
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| Format: | Article |
| Language: | English |
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BMC
2010-12-01
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| Series: | Molecular Cancer |
| Online Access: | http://www.molecular-cancer.com/content/9/1/313 |
| _version_ | 1811245839385886720 |
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| author | Gulmann Christian Downey Paul Guo Baoqiang Keld Richard Ang Yeng S Sharrocks Andrew D |
| author_facet | Gulmann Christian Downey Paul Guo Baoqiang Keld Richard Ang Yeng S Sharrocks Andrew D |
| author_sort | Gulmann Christian |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Many members of the ETS-domain transcription factor family are important drivers of tumourigenesis. In this context, their activation by Ras-ERK pathway signaling is particularly relevant to the tumourigenic properties of many ETS-domain transcription factors. The PEA3 subfamily of ETS-domain transcription factors have been implicated in tumour metastasis in several different cancers.</p> <p>Results</p> <p>Here, we have studied the expression of the PEA3 subfamily members PEA3/ETV4 and ER81/ETV1 in oesophageal adenocarcinomas and determined their role in oesophageal adenocarcinoma cell function. PEA3 plays an important role in controlling both the proliferation and invasive properties of OE33 oesophageal adenocarcinoma cells. A key target gene is <it>MMP-1</it>. The ERK MAP kinase pathway activates PEA3 subfamily members and also plays a role in these PEA3 controlled events, establishing the ERK-PEA3-MMP-1 axis as important in OE33 cells. PEA3 subfamily members are upregulated in human adenocarcinomas and expression correlates with <it>MMP-1 </it>expression and late stage metastatic disease. Enhanced ERK signaling is also more prevalent in late stage oesophageal adenocarcinomas.</p> <p>Conclusions</p> <p>This study shows that the ERK-PEA3-MMP-1 axis is upregulated in oesophageal adenocarcinoma cells and is a potentially important driver of the metastatic progression of oesophageal adenocarcinomas.</p> |
| first_indexed | 2024-04-12T14:45:20Z |
| format | Article |
| id | doaj.art-781e1ad23a374745bf35872446103fc8 |
| institution | Directory Open Access Journal |
| issn | 1476-4598 |
| language | English |
| last_indexed | 2024-04-12T14:45:20Z |
| publishDate | 2010-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Molecular Cancer |
| spelling | doaj.art-781e1ad23a374745bf35872446103fc82022-12-22T03:28:41ZengBMCMolecular Cancer1476-45982010-12-019131310.1186/1476-4598-9-313The ERK MAP kinase-PEA3/ETV4-MMP-1 axis is operative in oesophageal adenocarcinomaGulmann ChristianDowney PaulGuo BaoqiangKeld RichardAng Yeng SSharrocks Andrew D<p>Abstract</p> <p>Background</p> <p>Many members of the ETS-domain transcription factor family are important drivers of tumourigenesis. In this context, their activation by Ras-ERK pathway signaling is particularly relevant to the tumourigenic properties of many ETS-domain transcription factors. The PEA3 subfamily of ETS-domain transcription factors have been implicated in tumour metastasis in several different cancers.</p> <p>Results</p> <p>Here, we have studied the expression of the PEA3 subfamily members PEA3/ETV4 and ER81/ETV1 in oesophageal adenocarcinomas and determined their role in oesophageal adenocarcinoma cell function. PEA3 plays an important role in controlling both the proliferation and invasive properties of OE33 oesophageal adenocarcinoma cells. A key target gene is <it>MMP-1</it>. The ERK MAP kinase pathway activates PEA3 subfamily members and also plays a role in these PEA3 controlled events, establishing the ERK-PEA3-MMP-1 axis as important in OE33 cells. PEA3 subfamily members are upregulated in human adenocarcinomas and expression correlates with <it>MMP-1 </it>expression and late stage metastatic disease. Enhanced ERK signaling is also more prevalent in late stage oesophageal adenocarcinomas.</p> <p>Conclusions</p> <p>This study shows that the ERK-PEA3-MMP-1 axis is upregulated in oesophageal adenocarcinoma cells and is a potentially important driver of the metastatic progression of oesophageal adenocarcinomas.</p>http://www.molecular-cancer.com/content/9/1/313 |
| spellingShingle | Gulmann Christian Downey Paul Guo Baoqiang Keld Richard Ang Yeng S Sharrocks Andrew D The ERK MAP kinase-PEA3/ETV4-MMP-1 axis is operative in oesophageal adenocarcinoma Molecular Cancer |
| title | The ERK MAP kinase-PEA3/ETV4-MMP-1 axis is operative in oesophageal adenocarcinoma |
| title_full | The ERK MAP kinase-PEA3/ETV4-MMP-1 axis is operative in oesophageal adenocarcinoma |
| title_fullStr | The ERK MAP kinase-PEA3/ETV4-MMP-1 axis is operative in oesophageal adenocarcinoma |
| title_full_unstemmed | The ERK MAP kinase-PEA3/ETV4-MMP-1 axis is operative in oesophageal adenocarcinoma |
| title_short | The ERK MAP kinase-PEA3/ETV4-MMP-1 axis is operative in oesophageal adenocarcinoma |
| title_sort | erk map kinase pea3 etv4 mmp 1 axis is operative in oesophageal adenocarcinoma |
| url | http://www.molecular-cancer.com/content/9/1/313 |
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