Oral Vaccination With Recombinant Vesicular Stomatitis Virus Expressing Sin Nombre Virus Glycoprotein Prevents Sin Nombre Virus Transmission in Deer Mice

Oral Vaccination With Recombinant Vesicular Stomatitis Virus Expressing Sin Nombre Virus Glycoprotein Prevents Sin Nombre Virus Transmission in Deer Mice

Sin Nombre virus (SNV) is the major cause of hantavirus cardiopulmonary syndrome (HCPS) in North America, a severe respiratory disease with a high fatality rate. SNV is carried by Peromyscus maniculatus, or deer mice, and human infection occurs following inhalation of aerosolized virus in mouse excr...

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Bibliographic Details
Main Authors: Bryce M. Warner, Rohit K. Jangra, Bryan D. Griffin, Derek R. Stein, Darwyn Kobasa, Kartik Chandran, Gary P. Kobinger, David Safronetz
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
sin nombre virus
hantavirus
hantavirus cardiopulmonary syndrome
deer mice
Peromyscus maniculatus
Online Access:https://www.frontiersin.org/article/10.3389/fcimb.2020.00333/full

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