Diphenyleneiodonium Triggers Cell Death of Acute Myeloid Leukemia Cells by Blocking the Mitochondrial Respiratory Chain, and Synergizes with Cytarabine

Diphenyleneiodonium Triggers Cell Death of Acute Myeloid Leukemia Cells by Blocking the Mitochondrial Respiratory Chain, and Synergizes with Cytarabine

Acute myeloid leukemia (AML) is characterized by the accumulation of undifferentiated blast cells in the bone marrow and blood. In most cases of AML, relapse frequently occurs due to resistance to chemotherapy. Compelling research results indicate that drug resistance in cancer cells is highly depen...

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Bibliographic Details
Main Authors: Hassan Dakik, Maya El Dor, Jérôme Bourgeais, Farah Kouzi, Olivier Herault, Fabrice Gouilleux, Kazem Zibara, Frédéric Mazurier
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Cancers
Subjects:
DPI
mitochondria
leukemia
oxidative stress
OxPhos
Ara-C
Online Access:https://www.mdpi.com/2072-6694/14/10/2485

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