Lipid peroxidation and antioxidant status in blood of patients with uterine myoma, endometrial polypus, hyperplastic and malignant endometrium
Oxidative stress is considered to be involved in pathogenesis of many disorders of the female genital tract. In this study, we explored the lipid peroxidation levels and antioxidant enzyme activities in women diagnosed with different forms of uterine diseases in order to evaluate the extent of oxida...
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| Format: | Article |
| Language: | English |
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BMC
2006-01-01
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| Series: | Biological Research |
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| Online Access: | http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602006000500005 |
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| author | SNEZANA PEJIC JELENA KASAPOVIC ANA TODOROVIC VESNA STOJILJKOVIC SNEZANA B PAJOVIC |
| author_facet | SNEZANA PEJIC JELENA KASAPOVIC ANA TODOROVIC VESNA STOJILJKOVIC SNEZANA B PAJOVIC |
| author_sort | SNEZANA PEJIC |
| collection | DOAJ |
| description | Oxidative stress is considered to be involved in pathogenesis of many disorders of the female genital tract. In this study, we explored the lipid peroxidation levels and antioxidant enzyme activities in women diagnosed with different forms of uterine diseases in order to evaluate the extent of oxidative stress in blood of such patients. Blood samples of healthy subjects and gynecological patients were collected and subjected to assays for superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase and lipid hydroperoxides. The results show that alterations of measured parameters vary with the enzyme type and diagnosis. However, both reduction in antioxidants and elevation of lipid peroxidation were observed in general. Lipid hydroperoxides level was negatively correlated to superoxide dismutase and glutathione peroxidase activities, as well as positively correlated to catalase activity. In addition, the lipid hydroperoxides/ glutathione peroxidase ratio was found to be increased, according to the type of uterine disease. The obtained results show that perturbation of antioxidant status is more pronounced in blood of patients with premalignant (hyperplastic) and malignant (adenocarcinoma) lesions, compared to those with benign uterine changes such as polypus and myoma |
| first_indexed | 2024-12-12T17:46:45Z |
| format | Article |
| id | doaj.art-78252a9685dd4bd38cefb24e4102802a |
| institution | Directory Open Access Journal |
| issn | 0716-9760 0717-6287 |
| language | English |
| last_indexed | 2024-12-12T17:46:45Z |
| publishDate | 2006-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Biological Research |
| spelling | doaj.art-78252a9685dd4bd38cefb24e4102802a2022-12-22T00:16:54ZengBMCBiological Research0716-97600717-62872006-01-01394619629Lipid peroxidation and antioxidant status in blood of patients with uterine myoma, endometrial polypus, hyperplastic and malignant endometriumSNEZANA PEJICJELENA KASAPOVICANA TODOROVICVESNA STOJILJKOVICSNEZANA B PAJOVICOxidative stress is considered to be involved in pathogenesis of many disorders of the female genital tract. In this study, we explored the lipid peroxidation levels and antioxidant enzyme activities in women diagnosed with different forms of uterine diseases in order to evaluate the extent of oxidative stress in blood of such patients. Blood samples of healthy subjects and gynecological patients were collected and subjected to assays for superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase and lipid hydroperoxides. The results show that alterations of measured parameters vary with the enzyme type and diagnosis. However, both reduction in antioxidants and elevation of lipid peroxidation were observed in general. Lipid hydroperoxides level was negatively correlated to superoxide dismutase and glutathione peroxidase activities, as well as positively correlated to catalase activity. In addition, the lipid hydroperoxides/ glutathione peroxidase ratio was found to be increased, according to the type of uterine disease. The obtained results show that perturbation of antioxidant status is more pronounced in blood of patients with premalignant (hyperplastic) and malignant (adenocarcinoma) lesions, compared to those with benign uterine changes such as polypus and myomahttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602006000500005antioxidant enzymesendometrial polypusendometrial hyperplasiaendometrial adenocarcinomalipid peroxidationuterine myoma |
| spellingShingle | SNEZANA PEJIC JELENA KASAPOVIC ANA TODOROVIC VESNA STOJILJKOVIC SNEZANA B PAJOVIC Lipid peroxidation and antioxidant status in blood of patients with uterine myoma, endometrial polypus, hyperplastic and malignant endometrium Biological Research antioxidant enzymes endometrial polypus endometrial hyperplasia endometrial adenocarcinoma lipid peroxidation uterine myoma |
| title | Lipid peroxidation and antioxidant status in blood of patients with uterine myoma, endometrial polypus, hyperplastic and malignant endometrium |
| title_full | Lipid peroxidation and antioxidant status in blood of patients with uterine myoma, endometrial polypus, hyperplastic and malignant endometrium |
| title_fullStr | Lipid peroxidation and antioxidant status in blood of patients with uterine myoma, endometrial polypus, hyperplastic and malignant endometrium |
| title_full_unstemmed | Lipid peroxidation and antioxidant status in blood of patients with uterine myoma, endometrial polypus, hyperplastic and malignant endometrium |
| title_short | Lipid peroxidation and antioxidant status in blood of patients with uterine myoma, endometrial polypus, hyperplastic and malignant endometrium |
| title_sort | lipid peroxidation and antioxidant status in blood of patients with uterine myoma endometrial polypus hyperplastic and malignant endometrium |
| topic | antioxidant enzymes endometrial polypus endometrial hyperplasia endometrial adenocarcinoma lipid peroxidation uterine myoma |
| url | http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602006000500005 |
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