Neolignans from Licaria chrysophylla and Licaria aurea with DNA topoisomerase II-α inhibitory activity

Neolignans from Licaria chrysophylla and Licaria aurea with DNA topoisomerase II-α inhibitory activity

Seven natural neolignans isolated from Licaria chrysophylla and Licaria aurea along with five semisynthetic derivatives were tested for their inhibitory action on DNA-topoisomerase by relaxation assays on pBR322 plasmid DNA. All compounds tested showed strong inhibition at a concentration of 100 µM,...

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Bibliographic Details
Main Authors: Amanda de Melo Bezerra, Antônio Cláudio da Silva Lins, Petrônio Filgueiras de Athayde-Filho, Marcelo Sobral da Silva, José Maria Barbosa-Filho, Celso Amorim Camara, Tania Maria Sarmento Silva, Vanessa da Silva Luna, Creusioni Figueredo dos Santos
Format: Article
Language:English
Published: Sociedade Brasileira de Química 2012-01-01
Series:Química Nova
Subjects:
Licaria
lignoids
topoisomerase
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422012001100024&lng=en&tlng=en
Description
Summary:Seven natural neolignans isolated from Licaria chrysophylla and Licaria aurea along with five semisynthetic derivatives were tested for their inhibitory action on DNA-topoisomerase by relaxation assays on pBR322 plasmid DNA. All compounds tested showed strong inhibition at a concentration of 100 µM, while none showed activity between 5 and 70 µM. These results indicate that no obvious correlation can be derived between the structure of these compounds and their inhibitory effect on the DNA relaxation activity of topoisomerase II. This is the first report on DNA topoisomerase II inhibitors from Licaria chrysophylla and Licaria aurea leading to the identification of lignoids as topoisomerase II-α inhibitors.
ISSN:1678-7064

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