Neolignans from Licaria chrysophylla and Licaria aurea with DNA topoisomerase II-α inhibitory activity
Seven natural neolignans isolated from Licaria chrysophylla and Licaria aurea along with five semisynthetic derivatives were tested for their inhibitory action on DNA-topoisomerase by relaxation assays on pBR322 plasmid DNA. All compounds tested showed strong inhibition at a concentration of 100 µM,...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Química
2012-01-01
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| Series: | Química Nova |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422012001100024&lng=en&tlng=en |
| _version_ | 1818367172222648320 |
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| author | Amanda de Melo Bezerra Antônio Cláudio da Silva Lins Petrônio Filgueiras de Athayde-Filho Marcelo Sobral da Silva José Maria Barbosa-Filho Celso Amorim Camara Tania Maria Sarmento Silva Vanessa da Silva Luna Creusioni Figueredo dos Santos |
| author_facet | Amanda de Melo Bezerra Antônio Cláudio da Silva Lins Petrônio Filgueiras de Athayde-Filho Marcelo Sobral da Silva José Maria Barbosa-Filho Celso Amorim Camara Tania Maria Sarmento Silva Vanessa da Silva Luna Creusioni Figueredo dos Santos |
| author_sort | Amanda de Melo Bezerra |
| collection | DOAJ |
| description | Seven natural neolignans isolated from Licaria chrysophylla and Licaria aurea along with five semisynthetic derivatives were tested for their inhibitory action on DNA-topoisomerase by relaxation assays on pBR322 plasmid DNA. All compounds tested showed strong inhibition at a concentration of 100 µM, while none showed activity between 5 and 70 µM. These results indicate that no obvious correlation can be derived between the structure of these compounds and their inhibitory effect on the DNA relaxation activity of topoisomerase II. This is the first report on DNA topoisomerase II inhibitors from Licaria chrysophylla and Licaria aurea leading to the identification of lignoids as topoisomerase II-α inhibitors. |
| first_indexed | 2024-12-13T22:47:49Z |
| format | Article |
| id | doaj.art-78269557ae70491b9988704f3eaf8950 |
| institution | Directory Open Access Journal |
| issn | 1678-7064 |
| language | English |
| last_indexed | 2024-12-13T22:47:49Z |
| publishDate | 2012-01-01 |
| publisher | Sociedade Brasileira de Química |
| record_format | Article |
| series | Química Nova |
| spelling | doaj.art-78269557ae70491b9988704f3eaf89502022-12-21T23:28:41ZengSociedade Brasileira de QuímicaQuímica Nova1678-70642012-01-0135112226222810.1590/S0100-40422012001100024S0100-40422012001100024Neolignans from Licaria chrysophylla and Licaria aurea with DNA topoisomerase II-α inhibitory activityAmanda de Melo Bezerra0Antônio Cláudio da Silva Lins1Petrônio Filgueiras de Athayde-Filho2Marcelo Sobral da Silva3José Maria Barbosa-Filho4Celso Amorim Camara5Tania Maria Sarmento Silva6Vanessa da Silva Luna7Creusioni Figueredo dos Santos8Universidade Federal da ParaíbaUniversidade Federal da ParaíbaUniversidade Federal da ParaíbaUniversidade Federal da ParaíbaUniversidade Federal da ParaíbaUniversidade Federal Rural de PernambucoUniversidade Federal Rural de PernambucoUniversidade Federal da ParaíbaUniversidade Federal da ParaíbaSeven natural neolignans isolated from Licaria chrysophylla and Licaria aurea along with five semisynthetic derivatives were tested for their inhibitory action on DNA-topoisomerase by relaxation assays on pBR322 plasmid DNA. All compounds tested showed strong inhibition at a concentration of 100 µM, while none showed activity between 5 and 70 µM. These results indicate that no obvious correlation can be derived between the structure of these compounds and their inhibitory effect on the DNA relaxation activity of topoisomerase II. This is the first report on DNA topoisomerase II inhibitors from Licaria chrysophylla and Licaria aurea leading to the identification of lignoids as topoisomerase II-α inhibitors.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422012001100024&lng=en&tlng=enLicarialignoidstopoisomerase |
| spellingShingle | Amanda de Melo Bezerra Antônio Cláudio da Silva Lins Petrônio Filgueiras de Athayde-Filho Marcelo Sobral da Silva José Maria Barbosa-Filho Celso Amorim Camara Tania Maria Sarmento Silva Vanessa da Silva Luna Creusioni Figueredo dos Santos Neolignans from Licaria chrysophylla and Licaria aurea with DNA topoisomerase II-α inhibitory activity Química Nova Licaria lignoids topoisomerase |
| title | Neolignans from Licaria chrysophylla and Licaria aurea with DNA topoisomerase II-α inhibitory activity |
| title_full | Neolignans from Licaria chrysophylla and Licaria aurea with DNA topoisomerase II-α inhibitory activity |
| title_fullStr | Neolignans from Licaria chrysophylla and Licaria aurea with DNA topoisomerase II-α inhibitory activity |
| title_full_unstemmed | Neolignans from Licaria chrysophylla and Licaria aurea with DNA topoisomerase II-α inhibitory activity |
| title_short | Neolignans from Licaria chrysophylla and Licaria aurea with DNA topoisomerase II-α inhibitory activity |
| title_sort | neolignans from licaria chrysophylla and licaria aurea with dna topoisomerase ii α inhibitory activity |
| topic | Licaria lignoids topoisomerase |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422012001100024&lng=en&tlng=en |
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