Neolignans from Licaria chrysophylla and Licaria aurea with DNA topoisomerase II-α inhibitory activity

Neolignans from Licaria chrysophylla and Licaria aurea with DNA topoisomerase II-α inhibitory activity

Seven natural neolignans isolated from Licaria chrysophylla and Licaria aurea along with five semisynthetic derivatives were tested for their inhibitory action on DNA-topoisomerase by relaxation assays on pBR322 plasmid DNA. All compounds tested showed strong inhibition at a concentration of 100 µM,...

Full description

Bibliographic Details
Main Authors:	Amanda de Melo Bezerra, Antônio Cláudio da Silva Lins, Petrônio Filgueiras de Athayde-Filho, Marcelo Sobral da Silva, José Maria Barbosa-Filho, Celso Amorim Camara, Tania Maria Sarmento Silva, Vanessa da Silva Luna, Creusioni Figueredo dos Santos
Format:	Article
Language:	English
Published:	Sociedade Brasileira de Química 2012-01-01
Series:	Química Nova
Subjects:	Licaria lignoids topoisomerase
Online Access:	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422012001100024&lng=en&tlng=en

Similar Items

INFLUÊNCIA DO SOMBREAMENTO NO DESENVOLVIMENTO DE MUDAS DE LOURO PIRARUCU (Licaria canella (Meissn.) Kosterm.)
by: Antonio M. PINTO, et al.
Published: (1993-01-01)

Phaeophytins from Thyrsacanthus ramosissimus Moric. with inhibitory activity on human dna topoisomerase II-α
by: Analúcia Guedes Silveira Cabral, et al.
Published: (2012-01-01)

Licaria ramiroi (Lauraceae), a new species from Western Mexico
by: Ramón Cuevas Guzmán, et al.
Published: (2023-01-01)

Nuevas especies de Licaria, Ocotea y Persea (Lauraceae) de México
by: Francisco G. Lorea-Hern\u00E1ndez
Published: (2005-01-01)

Assessment of the dendrochronological potential of Licaria bahiana Kurz, an endemic laurel of lowland Atlantic forests in Brazil
by: Cláudia Fontana, et al.

Aplysfistularine: a novel dibromotyrosine derivative isolated from Aplysina fistularis
by: Narlize Silva Lira, et al.
Published: (2012-01-01)

Plasmodium Topoisomerase VIB and Spo11 Constitute Functional Type IIB Topoisomerase in Malaria Parasite: Its Possible Role in Mitochondrial DNA Segregation
by: Priyanka Singh, et al.
Published: (2023-06-01)

Inhibitory effects of lapachol on rat C6 glioma in vitro and in vivo by targeting DNA topoisomerase I and topoisomerase II
by: Huanli Xu, et al.
Published: (2016-11-01)

Phosphorylation of the human topoisomerase II protein
by: Fry, A, et al.
Published: (1992)

Actions of a Novel Bacterial Topoisomerase Inhibitor against <i>Neisseria gonorrhoeae</i> Gyrase and Topoisomerase IV: Enhancement of Double-Stranded DNA Breaks
by: Soziema E. Dauda, et al.
Published: (2023-07-01)

Evodiamine Stabilizes Topoisomerase I-DNA Cleavable Complex to Inhibit Topoisomerase I Activity
by: Jau-Lang Hwang, et al.
Published: (2009-03-01)

DNA topoisomerases as molecular targets for anticancer drugs
by: Kamila Buzun, et al.
Published: (2020-01-01)

SUMO: A Swiss Army Knife for Eukaryotic Topoisomerases
by: Yilun Sun, et al.
Published: (2022-04-01)

Chemical Diversity and Biological Activities of Essential Oils from <i>Licaria</i>, <i>Nectrandra</i> and <i>Ocotea</i> Species (Lauraceae) with Occurrence in Brazilian Biomes
by: Júlia Karla A. M. Xavier, et al.
Published: (2020-06-01)

Inhibition of Topoisomerases by Metal Thiosemicarbazone Complexes
by: Xiaohua Jiang, et al.
Published: (2023-07-01)

Synthesis, DNA Binding and Topoisomerase I Inhibition Activity of Thiazacridine and Imidazacridine Derivatives
by: Elizabeth Almeida Lafayette, et al.
Published: (2013-12-01)

Design, synthesis and antiproliferative evaluation of new acridine-thiosemicarbazone derivatives as topoisomerase IIα inhibitors
by: Gleyton Leonel Silva Sousa, et al.
Published: (2024-01-01)

Natural Compounds as Therapeutic Agents: The Case of Human Topoisomerase IB
by: Alessio Ottaviani, et al.
Published: (2021-04-01)

A Short History of Topoisomerases at Actelion Pharmaceuticals
by: Cornelia Zumbrunn
Published: (2022-08-01)

Gel-Free Tools for Quick and Simple Screening of Anti-Topoisomerase 1 Compounds
by: Josephine Geertsen Keller, et al.
Published: (2023-04-01)

What’s on the Other Side of the Gate: A Structural Perspective on DNA Gate Opening of Type IA and IIA DNA Topoisomerases
by: Vita Vidmar, et al.
Published: (2023-02-01)

Type IA Topoisomerases as Targets for Infectious Disease Treatments
by: Ahmed Seddek, et al.
Published: (2021-01-01)

The Potential of Topoisomerase Inhibitor-Based Antibody–Drug Conjugates
by: Seungmin Han, et al.
Published: (2022-08-01)

Role of Topoisomerases in Pediatric High Grade Osteosarcomas: TOP2A Gene Is One of the Unique Molecular Biomarkers of Chemoresponse
by: Natacha Entz-Werle, et al.
Published: (2013-06-01)

Dioxane-Linked Novel Bacterial Topoisomerase Inhibitors Exhibit Bactericidal Activity against Planktonic and Biofilm Staphylococcus aureus In Vitro
by: Anna Chen, et al.
Published: (2022-12-01)

The Implication of Topoisomerase II Inhibitors in Synthetic Lethality for Cancer Therapy
by: Victor M. Matias-Barrios, et al.
Published: (2023-01-01)

Bulge oligonucleotide as an inhibitory agent of bacterial topoisomerase I
by: Zhaoqi Yang, et al.
Published: (2018-01-01)

Palindromic carbazole derivatives: unveiling their antiproliferative effect via topoisomerase II catalytic inhibition and apoptosis induction
by: Mateusz Olszewski, et al.
Published: (2024-12-01)

Mechanism of Type IA Topoisomerases
by: Tumpa Dasgupta, et al.
Published: (2020-10-01)

Resveratrol Modulates the Topoisomerase Inhibitory Potential of Doxorubicin in Human Colon Carcinoma Cells
by: Anika Schroeter, et al.
Published: (2014-12-01)

Archaea: A Gold Mine for Topoisomerase Diversity
by: Florence Garnier, et al.
Published: (2021-05-01)

Developments in Non-Intercalating Bacterial Topoisomerase Inhibitors: Allosteric and ATPase Inhibitors of DNA Gyrase and Topoisomerase IV
by: Scott Grossman, et al.
Published: (2023-02-01)

Effect of etoposide on grass pea DNA topoisomerase II: an in silico, in vivo, and in vitro assessments
by: Aveek Samanta, et al.
Published: (2019-12-01)

Synthesis and Evaluation of Antiproliferative Activity, Topoisomerase IIα Inhibition, DNA Binding and Non-Clinical Toxicity of New Acridine–Thiosemicarbazone Derivatives
by: Gleyton Sousa, et al.
Published: (2022-09-01)

Structural and Biochemical Basis of Etoposide-Resistant Mutations in Topoisomerase IIα
by: Elizabeth G. Gibson, et al.
Published: (2022-06-01)

Prospects of Topoisomerase Inhibitors as Promising Anti-Cancer Agents
by: Prasanna Anjaneyulu Yakkala, et al.
Published: (2023-10-01)

Dual Targeting Topoisomerase/G-Quadruplex Agents in Cancer Therapy—An Overview
by: Silvia Salerno, et al.
Published: (2022-11-01)

Solvent-Free Synthesis, DNA-Topoisomerase II Activity and Molecular Docking Study of New Asymmetrically N,N'-Substituted Ureas
by: Aurea Echevarria, et al.
Published: (2012-11-01)

Women’s contribution in understanding how topoisomerases, supercoiling, and transcription control genome organization
by: Laura Martin, et al.
Published: (2023-03-01)

Prognostic Significance of DNA Topoisomerase II Alpha (TOP2A) in Cholangiocarcinoma
by: Khaa Hoo Ong, et al.
Published: (2023-04-01)