A RARE HISTOLOGICAL FINDING AFTER PANCREATICODUODENECTOMY
In this paper, we describe the case of successful surgical treatment of a rare combination of three malignant tumors of the major duodenal papilla in one patient. A 59-year-old woman presented with abdominal pain, fever, nausea, vomiting, weight loss and obstructive jaundice. After routine examinati...
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| Format: | Article |
| Language: | Russian |
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Russian Academy of Sciences, Tomsk National Research Medical Center
2021-05-01
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| Series: | Сибирский онкологический журнал |
| Subjects: | |
| Online Access: | https://www.siboncoj.ru/jour/article/view/1766 |
| _version_ | 1797875799940923392 |
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| author | V. Y. Rayn M. A. Persidskiy V. P. Ionin E. D. Khadieva |
| author_facet | V. Y. Rayn M. A. Persidskiy V. P. Ionin E. D. Khadieva |
| author_sort | V. Y. Rayn |
| collection | DOAJ |
| description | In this paper, we describe the case of successful surgical treatment of a rare combination of three malignant tumors of the major duodenal papilla in one patient. A 59-year-old woman presented with abdominal pain, fever, nausea, vomiting, weight loss and obstructive jaundice. After routine examination, the patient with suspected cancer of the major duodenal papilla underwent pylorus-sparing pancreatoduodenal resection. Final histology revealed a rare collision of three types of cancer in the major duodenal papilla invading the pancreatic head: moderately-differentiated adenocarcinoma (30 %), moderately differentiated squamous cell carcinoma (20 %) and poorly differentiated small cell neuroendocrine cancer (50 %), surgical resection margins were intact. Immunohistochemical analysis revealed positivity for synaptophysin, chromogranin A and cytokeratin 5/6. The tumor diameter of 2 cm and the absence of signs of locoregional spread allowed the process to be staged as T2N0M0, so the patient did not receive any adjuvant treatment. Follow-up CT performed 6 months later showed two lesions in the liver, and biopsy of one of them was performed. Metastasis of neuroendocrine cancer was histologically and immunohistochemically verified. She started first-line chemotherapy with etoposide + cisplatin. |
| first_indexed | 2024-04-10T01:52:16Z |
| format | Article |
| id | doaj.art-7827992e9f754e86884b00915d152986 |
| institution | Directory Open Access Journal |
| issn | 1814-4861 2312-3168 |
| language | Russian |
| last_indexed | 2024-04-10T01:52:16Z |
| publishDate | 2021-05-01 |
| publisher | Russian Academy of Sciences, Tomsk National Research Medical Center |
| record_format | Article |
| series | Сибирский онкологический журнал |
| spelling | doaj.art-7827992e9f754e86884b00915d1529862023-03-13T09:05:54ZrusRussian Academy of Sciences, Tomsk National Research Medical CenterСибирский онкологический журнал1814-48612312-31682021-05-0120213614010.21294/1814-4861-2021-20-2-136-140854A RARE HISTOLOGICAL FINDING AFTER PANCREATICODUODENECTOMYV. Y. Rayn0M. A. Persidskiy1V. P. Ionin2E. D. Khadieva3БУ ВО «Ханты-Мансийская государственная медицинская академия»; БУ «Окружная клиническая больница»БУ «Окружная клиническая больница»БУ ВО «Ханты-Мансийская государственная медицинская академия»БУ «Окружная клиническая больница»In this paper, we describe the case of successful surgical treatment of a rare combination of three malignant tumors of the major duodenal papilla in one patient. A 59-year-old woman presented with abdominal pain, fever, nausea, vomiting, weight loss and obstructive jaundice. After routine examination, the patient with suspected cancer of the major duodenal papilla underwent pylorus-sparing pancreatoduodenal resection. Final histology revealed a rare collision of three types of cancer in the major duodenal papilla invading the pancreatic head: moderately-differentiated adenocarcinoma (30 %), moderately differentiated squamous cell carcinoma (20 %) and poorly differentiated small cell neuroendocrine cancer (50 %), surgical resection margins were intact. Immunohistochemical analysis revealed positivity for synaptophysin, chromogranin A and cytokeratin 5/6. The tumor diameter of 2 cm and the absence of signs of locoregional spread allowed the process to be staged as T2N0M0, so the patient did not receive any adjuvant treatment. Follow-up CT performed 6 months later showed two lesions in the liver, and biopsy of one of them was performed. Metastasis of neuroendocrine cancer was histologically and immunohistochemically verified. She started first-line chemotherapy with etoposide + cisplatin.https://www.siboncoj.ru/jour/article/view/1766нейроэндокринный ракплоскоклеточный рак большого дуоденального сосочкааденокарцинома бдспилоросохраняющая панкреатодуоденальная резекцияфатерова ампула |
| spellingShingle | V. Y. Rayn M. A. Persidskiy V. P. Ionin E. D. Khadieva A RARE HISTOLOGICAL FINDING AFTER PANCREATICODUODENECTOMY Сибирский онкологический журнал нейроэндокринный рак плоскоклеточный рак большого дуоденального сосочка аденокарцинома бдс пилоросохраняющая панкреатодуоденальная резекция фатерова ампула |
| title | A RARE HISTOLOGICAL FINDING AFTER PANCREATICODUODENECTOMY |
| title_full | A RARE HISTOLOGICAL FINDING AFTER PANCREATICODUODENECTOMY |
| title_fullStr | A RARE HISTOLOGICAL FINDING AFTER PANCREATICODUODENECTOMY |
| title_full_unstemmed | A RARE HISTOLOGICAL FINDING AFTER PANCREATICODUODENECTOMY |
| title_short | A RARE HISTOLOGICAL FINDING AFTER PANCREATICODUODENECTOMY |
| title_sort | rare histological finding after pancreaticoduodenectomy |
| topic | нейроэндокринный рак плоскоклеточный рак большого дуоденального сосочка аденокарцинома бдс пилоросохраняющая панкреатодуоденальная резекция фатерова ампула |
| url | https://www.siboncoj.ru/jour/article/view/1766 |
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