Tumor cell-derived asymmetric dimethylarginine regulates macrophage functions and polarization

Tumor cell-derived asymmetric dimethylarginine regulates macrophage functions and polarization

Abstract Background Asymmetric dimethylarginine (ADMA), which is significantly elevated in the plasma of cancer patients, is formed via intracellular recycling of methylated proteins and serves as a precursor for resynthesis of arginine. However, the cause of ADMA elevation in cancers and its impact...

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Bibliographic Details
Main Authors: Yi-Ling Chen, AKaychia T. Lowery, Samuel Lin, Ameae M. Walker, Kuan-Hui E. Chen
Format: Article
Language:English
Published: BMC 2022-11-01
Series:Cancer Cell International
Subjects:
Arginine metabolism
Asymmetric dimethylarginine
cancer stem cells
Autophagy
Macrophage polarization
Online Access:https://doi.org/10.1186/s12935-022-02769-7

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