Molecular investigation of a fungemia outbreak due to Candida parapsilosis in an intensive care unit
We investigated a nosocomial cluster of four Candida parapsilosis fungemia episodes that occurred in a neurological intensive care unit over a two-week period. The four infected patients had received parenteral nutrition through central lines, and all four had catheter-related candidemia. All of the...
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
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| Series: | Brazilian Journal of Infectious Diseases |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000500010&lng=en&tlng=en |
| _version_ | 1818967379754876928 |
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| author | Murat Dizbay Ayse Kalkanci Busra Ergut Sezer Firdevs Aktas Sibel Aydogan Isil Fidan Semra Kustimur Takashi Sugita |
| author_facet | Murat Dizbay Ayse Kalkanci Busra Ergut Sezer Firdevs Aktas Sibel Aydogan Isil Fidan Semra Kustimur Takashi Sugita |
| author_sort | Murat Dizbay |
| collection | DOAJ |
| description | We investigated a nosocomial cluster of four Candida parapsilosis fungemia episodes that occurred in a neurological intensive care unit over a two-week period. The four infected patients had received parenteral nutrition through central lines, and all four had catheter-related candidemia. All of the isolates were susceptible to all of the antifungals tested, including amphotericin B, fluconazole, voriconazole, and caspofungin. They had strictly related fingerprints, based on randomly amplified polymorphic DNA analysis. Additional DNA sequencing data revealed that they were same strain. Although no isolate of Candida parapsilosis was recovered from other clinical, surveillance, or environmental samples, nosocomial spread of this yeast ceased, following the reinforcement of infection-control measures. Candida parapsilosis may require an intravascular foreign body to cause fungemia, but this outbreak shows that it can be transmitted nosocomially and can cause epidemics. |
| first_indexed | 2024-12-20T13:47:52Z |
| format | Article |
| id | doaj.art-782ac967a130497cba60c45568153f82 |
| institution | Directory Open Access Journal |
| issn | 1678-4391 |
| language | English |
| last_indexed | 2024-12-20T13:47:52Z |
| publisher | Elsevier |
| record_format | Article |
| series | Brazilian Journal of Infectious Diseases |
| spelling | doaj.art-782ac967a130497cba60c45568153f822022-12-21T19:38:36ZengElsevierBrazilian Journal of Infectious Diseases1678-439112539539910.1590/S1413-86702008000500010S1413-86702008000500010Molecular investigation of a fungemia outbreak due to Candida parapsilosis in an intensive care unitMurat Dizbay0Ayse Kalkanci1Busra Ergut Sezer2Firdevs Aktas3Sibel Aydogan4Isil Fidan5Semra Kustimur6Takashi Sugita7Gazi UniversityGazi UniversityGazi UniversityGazi UniversityGazi UniversityGazi UniversityGazi UniversityMeiji Pharmaceutical UniversityWe investigated a nosocomial cluster of four Candida parapsilosis fungemia episodes that occurred in a neurological intensive care unit over a two-week period. The four infected patients had received parenteral nutrition through central lines, and all four had catheter-related candidemia. All of the isolates were susceptible to all of the antifungals tested, including amphotericin B, fluconazole, voriconazole, and caspofungin. They had strictly related fingerprints, based on randomly amplified polymorphic DNA analysis. Additional DNA sequencing data revealed that they were same strain. Although no isolate of Candida parapsilosis was recovered from other clinical, surveillance, or environmental samples, nosocomial spread of this yeast ceased, following the reinforcement of infection-control measures. Candida parapsilosis may require an intravascular foreign body to cause fungemia, but this outbreak shows that it can be transmitted nosocomially and can cause epidemics.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000500010&lng=en&tlng=enCandidemiaCandida parapsilosisnosocomial outbreakintensive care unitRAPDDNA sequencing |
| spellingShingle | Murat Dizbay Ayse Kalkanci Busra Ergut Sezer Firdevs Aktas Sibel Aydogan Isil Fidan Semra Kustimur Takashi Sugita Molecular investigation of a fungemia outbreak due to Candida parapsilosis in an intensive care unit Brazilian Journal of Infectious Diseases Candidemia Candida parapsilosis nosocomial outbreak intensive care unit RAPD DNA sequencing |
| title | Molecular investigation of a fungemia outbreak due to Candida parapsilosis in an intensive care unit |
| title_full | Molecular investigation of a fungemia outbreak due to Candida parapsilosis in an intensive care unit |
| title_fullStr | Molecular investigation of a fungemia outbreak due to Candida parapsilosis in an intensive care unit |
| title_full_unstemmed | Molecular investigation of a fungemia outbreak due to Candida parapsilosis in an intensive care unit |
| title_short | Molecular investigation of a fungemia outbreak due to Candida parapsilosis in an intensive care unit |
| title_sort | molecular investigation of a fungemia outbreak due to candida parapsilosis in an intensive care unit |
| topic | Candidemia Candida parapsilosis nosocomial outbreak intensive care unit RAPD DNA sequencing |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000500010&lng=en&tlng=en |
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