Anti-diabetic and anti-oxidant status of Loranthus pulverulentus obtained from two different hosts
Leaves of Loranthus pulverulentus have been used ethnically in Pakistan for controlling blood glucose levels. The present study was designed to investigate the anti-diabetic and anti-oxidant potential of the methanolic extracted fractions of L. pulverulentus obtained from two different hosts viz. Da...
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| Format: | Article |
| Language: | English |
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Bangladesh Pharmacological Society
2016-01-01
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| Series: | Bangladesh Journal of Pharmacology |
| Subjects: | |
| Online Access: | https://www.banglajol.info/index.php/BJP/article/view/24056 |
| _version_ | 1819026468819173376 |
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| author | Sairah Hafeez Kamran Mobasher Ahmad Durre Shahwar Muhammad Ajaib |
| author_facet | Sairah Hafeez Kamran Mobasher Ahmad Durre Shahwar Muhammad Ajaib |
| author_sort | Sairah Hafeez Kamran |
| collection | DOAJ |
| description | Leaves of Loranthus pulverulentus have been used ethnically in Pakistan for controlling blood glucose levels. The present study was designed to investigate the anti-diabetic and anti-oxidant potential of the methanolic extracted fractions of L. pulverulentus obtained from two different hosts viz. Dalbergia sissoo and Populus nigra. The acute study demonstrated that L. pulverulentus (D. sissoo) leaves possess significant blood glucose lowering effect whereas L. pulverulentus (P. nigra) was didnt significantly decreased blood glucose levels. The n-butanol fraction of L. pulverulentus (D. sissoo) also significantly increased in vivo total anti-oxidant activity on eighth day after treatment and blood glucose levels were significantly reduced (%46.7) when compared to the control diabetic group (%?198.1) and metformin treated group (%?25.9). Leaves of L. pulverulentus (D. sissoo) have good margin of safety as therapeutic index is 3.5. This study provides scientific evidence that leaves of L. pulverulentus (D. sissoo) possess potential anti-diabetic activity whereas L. pulverulentus (P. nigra) was not found effective in diabetic illness. |
| first_indexed | 2024-12-21T05:27:04Z |
| format | Article |
| id | doaj.art-782adae335d744cba4b488fdf859be41 |
| institution | Directory Open Access Journal |
| issn | 1991-0088 |
| language | English |
| last_indexed | 2024-12-21T05:27:04Z |
| publishDate | 2016-01-01 |
| publisher | Bangladesh Pharmacological Society |
| record_format | Article |
| series | Bangladesh Journal of Pharmacology |
| spelling | doaj.art-782adae335d744cba4b488fdf859be412022-12-21T19:14:40ZengBangladesh Pharmacological SocietyBangladesh Journal of Pharmacology1991-00882016-01-0111110.3329/bjp.v11i1.24056Anti-diabetic and anti-oxidant status of Loranthus pulverulentus obtained from two different hostsSairah Hafeez Kamran0Mobasher Ahmad1Durre Shahwar2Muhammad Ajaib3University College of Pharmacy, University of the Punjab, Allama Iqbal Campus, Lahore 54000University College of Pharmacy, University of the Punjab, Allama Iqbal Campus, Lahore 54000Department of Chemistry, Government College University, Lahore 54000Department of Botany, Government College University, Lahore 54000Leaves of Loranthus pulverulentus have been used ethnically in Pakistan for controlling blood glucose levels. The present study was designed to investigate the anti-diabetic and anti-oxidant potential of the methanolic extracted fractions of L. pulverulentus obtained from two different hosts viz. Dalbergia sissoo and Populus nigra. The acute study demonstrated that L. pulverulentus (D. sissoo) leaves possess significant blood glucose lowering effect whereas L. pulverulentus (P. nigra) was didnt significantly decreased blood glucose levels. The n-butanol fraction of L. pulverulentus (D. sissoo) also significantly increased in vivo total anti-oxidant activity on eighth day after treatment and blood glucose levels were significantly reduced (%46.7) when compared to the control diabetic group (%?198.1) and metformin treated group (%?25.9). Leaves of L. pulverulentus (D. sissoo) have good margin of safety as therapeutic index is 3.5. This study provides scientific evidence that leaves of L. pulverulentus (D. sissoo) possess potential anti-diabetic activity whereas L. pulverulentus (P. nigra) was not found effective in diabetic illness.https://www.banglajol.info/index.php/BJP/article/view/24056Anti-diabeticAnti-oxidantDalbergia sissooLoranthus pulverulentusPopulus nigra |
| spellingShingle | Sairah Hafeez Kamran Mobasher Ahmad Durre Shahwar Muhammad Ajaib Anti-diabetic and anti-oxidant status of Loranthus pulverulentus obtained from two different hosts Bangladesh Journal of Pharmacology Anti-diabetic Anti-oxidant Dalbergia sissoo Loranthus pulverulentus Populus nigra |
| title | Anti-diabetic and anti-oxidant status of Loranthus pulverulentus obtained from two different hosts |
| title_full | Anti-diabetic and anti-oxidant status of Loranthus pulverulentus obtained from two different hosts |
| title_fullStr | Anti-diabetic and anti-oxidant status of Loranthus pulverulentus obtained from two different hosts |
| title_full_unstemmed | Anti-diabetic and anti-oxidant status of Loranthus pulverulentus obtained from two different hosts |
| title_short | Anti-diabetic and anti-oxidant status of Loranthus pulverulentus obtained from two different hosts |
| title_sort | anti diabetic and anti oxidant status of loranthus pulverulentus obtained from two different hosts |
| topic | Anti-diabetic Anti-oxidant Dalbergia sissoo Loranthus pulverulentus Populus nigra |
| url | https://www.banglajol.info/index.php/BJP/article/view/24056 |
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