Comparison of Methods for Estimating Retinal Shape: Peripheral Refraction vs. Optical Coherence Tomography
Retinal shape presents a clinical parameter of interest for myopia, and has commonly been inferred indirectly from peripheral refraction (PRX) profiles. Distortion-corrected optical coherence tomography (OCT) scans offer a new and direct possibility for retinal shape estimation. The current study co...
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| Format: | Article |
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MDPI AG
2021-01-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/10/2/174 |
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| author | Katharina Breher Alejandro Calabuig Laura Kühlewein Focke Ziemssen Arne Ohlendorf Siegfried Wahl |
| author_facet | Katharina Breher Alejandro Calabuig Laura Kühlewein Focke Ziemssen Arne Ohlendorf Siegfried Wahl |
| author_sort | Katharina Breher |
| collection | DOAJ |
| description | Retinal shape presents a clinical parameter of interest for myopia, and has commonly been inferred indirectly from peripheral refraction (PRX) profiles. Distortion-corrected optical coherence tomography (OCT) scans offer a new and direct possibility for retinal shape estimation. The current study compared retinal curvatures derived from OCT scans vs. PRX measurements in three refractive profiles (0<inline-formula><math display="inline"><semantics><msup><mrow></mrow><mo>°</mo></msup></semantics></math></inline-formula> and 90<inline-formula><math display="inline"><semantics><msup><mrow></mrow><mo>°</mo></msup></semantics></math></inline-formula> meridians, plus spherical equivalent) for 25 participants via Bland–Altman analysis. The radial differences between both procedures were correlated to axial length using Pearson correlation. In general, PRX- and OCT-based retinal radii showed low correlation (all intraclass correlation coefficients < 0.21). PRX found flatter retinal curvatures compared to OCT, with the highest absolute agreement found with the 90<inline-formula><math display="inline"><semantics><msup><mrow></mrow><mo>°</mo></msup></semantics></math></inline-formula> meridian (mean difference +0.08 mm) and lowest in the 0<inline-formula><math display="inline"><semantics><msup><mrow></mrow><mo>°</mo></msup></semantics></math></inline-formula> meridian (mean difference +0.89 mm). Moreover, a negative relation between axial length and the agreement of both methods was detected especially in the 90<inline-formula><math display="inline"><semantics><msup><mrow></mrow><mo>°</mo></msup></semantics></math></inline-formula> meridian (R = −0.38, <i>p</i> = 0.06). PRX measurements tend to underestimate the retinal radius with increasing myopia when compared to OCT measurements. Therefore, future conclusions from PRX on retinal shape should be made cautiously. Rather, faster and more clinically feasible OCT imaging should be performed for this purpose. |
| first_indexed | 2024-03-10T13:27:08Z |
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| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T13:27:08Z |
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| spelling | doaj.art-782b71a8edd745bc8c9b1775cb0723372023-11-21T08:56:03ZengMDPI AGJournal of Clinical Medicine2077-03832021-01-0110217410.3390/jcm10020174Comparison of Methods for Estimating Retinal Shape: Peripheral Refraction vs. Optical Coherence TomographyKatharina Breher0Alejandro Calabuig1Laura Kühlewein2Focke Ziemssen3Arne Ohlendorf4Siegfried Wahl5Institute for Ophthalmic Research, University of Tübingen, 72076 Tübingen, GermanyInstitute for Ophthalmic Research, University of Tübingen, 72076 Tübingen, GermanyInstitute for Ophthalmic Research, University of Tübingen, 72076 Tübingen, GermanyCenter for Ophthalmology, University of Tübingen, 72076 Tübingen, GermanyCarl Zeiss Vision International GmbH, 73430 Aalen, GermanyInstitute for Ophthalmic Research, University of Tübingen, 72076 Tübingen, GermanyRetinal shape presents a clinical parameter of interest for myopia, and has commonly been inferred indirectly from peripheral refraction (PRX) profiles. Distortion-corrected optical coherence tomography (OCT) scans offer a new and direct possibility for retinal shape estimation. The current study compared retinal curvatures derived from OCT scans vs. PRX measurements in three refractive profiles (0<inline-formula><math display="inline"><semantics><msup><mrow></mrow><mo>°</mo></msup></semantics></math></inline-formula> and 90<inline-formula><math display="inline"><semantics><msup><mrow></mrow><mo>°</mo></msup></semantics></math></inline-formula> meridians, plus spherical equivalent) for 25 participants via Bland–Altman analysis. The radial differences between both procedures were correlated to axial length using Pearson correlation. In general, PRX- and OCT-based retinal radii showed low correlation (all intraclass correlation coefficients < 0.21). PRX found flatter retinal curvatures compared to OCT, with the highest absolute agreement found with the 90<inline-formula><math display="inline"><semantics><msup><mrow></mrow><mo>°</mo></msup></semantics></math></inline-formula> meridian (mean difference +0.08 mm) and lowest in the 0<inline-formula><math display="inline"><semantics><msup><mrow></mrow><mo>°</mo></msup></semantics></math></inline-formula> meridian (mean difference +0.89 mm). Moreover, a negative relation between axial length and the agreement of both methods was detected especially in the 90<inline-formula><math display="inline"><semantics><msup><mrow></mrow><mo>°</mo></msup></semantics></math></inline-formula> meridian (R = −0.38, <i>p</i> = 0.06). PRX measurements tend to underestimate the retinal radius with increasing myopia when compared to OCT measurements. Therefore, future conclusions from PRX on retinal shape should be made cautiously. Rather, faster and more clinically feasible OCT imaging should be performed for this purpose.https://www.mdpi.com/2077-0383/10/2/174myopiaretinal shapeperipheral refraction |
| spellingShingle | Katharina Breher Alejandro Calabuig Laura Kühlewein Focke Ziemssen Arne Ohlendorf Siegfried Wahl Comparison of Methods for Estimating Retinal Shape: Peripheral Refraction vs. Optical Coherence Tomography Journal of Clinical Medicine myopia retinal shape peripheral refraction |
| title | Comparison of Methods for Estimating Retinal Shape: Peripheral Refraction vs. Optical Coherence Tomography |
| title_full | Comparison of Methods for Estimating Retinal Shape: Peripheral Refraction vs. Optical Coherence Tomography |
| title_fullStr | Comparison of Methods for Estimating Retinal Shape: Peripheral Refraction vs. Optical Coherence Tomography |
| title_full_unstemmed | Comparison of Methods for Estimating Retinal Shape: Peripheral Refraction vs. Optical Coherence Tomography |
| title_short | Comparison of Methods for Estimating Retinal Shape: Peripheral Refraction vs. Optical Coherence Tomography |
| title_sort | comparison of methods for estimating retinal shape peripheral refraction vs optical coherence tomography |
| topic | myopia retinal shape peripheral refraction |
| url | https://www.mdpi.com/2077-0383/10/2/174 |
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