Adenovirus and Mycoplasma pneumoniae co-infection as a risk factor for severe community-acquired pneumonia in children
BackgroundTo investigate the pathogenic characteristics and risk factors of pediatric severe community-acquired pneumonia (CAP).MethodsWe retrospectively analyzed the clinical data of hospitalized children with severe CAP from April 2014 to June 2019 in China. Data of age, sex and pathogenic results...
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| Format: | Article |
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Frontiers Media S.A.
2024-01-01
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| Series: | Frontiers in Pediatrics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fped.2024.1337786/full |
| _version_ | 1797338424840028160 |
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| author | Qihong Chen Qihong Chen Lihua Lin Lihua Lin Ning Zhang Ning Zhang Yungang Yang Yungang Yang |
| author_facet | Qihong Chen Qihong Chen Lihua Lin Lihua Lin Ning Zhang Ning Zhang Yungang Yang Yungang Yang |
| author_sort | Qihong Chen |
| collection | DOAJ |
| description | BackgroundTo investigate the pathogenic characteristics and risk factors of pediatric severe community-acquired pneumonia (CAP).MethodsWe retrospectively analyzed the clinical data of hospitalized children with severe CAP from April 2014 to June 2019 in China. Data of age, sex and pathogenic results were collected: bacterial and fungal cultures, respiratory viruses from sputum or bronchoalveolar lavage fluid (BALF), serum Mycoplasma pneumoniae (MP)-IgM and Chlamydia Pneumoniae-IgM, and BALF or blood (1-3)-β-D-glucan/galactomannan test.ResultsA total of 679 children with severe CAP were included in the analysis. The number of cases infected with MP was higher in males than in females. There were significant differences between the ≤1-year and >1-year groups in terms of pathogen. The top three bacteria cultured were Haemophilus influenzae (57/679, 8.4%), Streptococcus pneumoniae (50/679, 7.4%), and Pseudomonas aeruginosa (25/679, 3.7%). The top three viruses detected were adenovirus (AdV, 124/679, 18.3%), respiratory syncytial virus (24/679, 3.5%), and parainfluenza virus (21/679, 3.1%). AdV and MP were the leading pathogens, detected in 18.3% and 32.6% cases, respectively. MP infection increased the risk of AdV infection (OR 3.77, p < 0.0001). MP infection was a risk factor for severe AdV-infected pneumonia, while sex, age, bacteria, Chlamydia Pneumoniae, fungal, and AdV infections were risk factors for severe MP-infected pneumonia.ConclusionsAdV and MP were dominant pathogens in children with severe CAP. AdV and MP infection predisposed each other to develop severe illness. AdV-MP co-infection may lead to severe pneumonia. |
| first_indexed | 2024-03-08T09:30:01Z |
| format | Article |
| id | doaj.art-782f7255ef0445d686afd321c5808a1d |
| institution | Directory Open Access Journal |
| issn | 2296-2360 |
| language | English |
| last_indexed | 2024-03-08T09:30:01Z |
| publishDate | 2024-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pediatrics |
| spelling | doaj.art-782f7255ef0445d686afd321c5808a1d2024-01-31T04:35:47ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602024-01-011210.3389/fped.2024.13377861337786Adenovirus and Mycoplasma pneumoniae co-infection as a risk factor for severe community-acquired pneumonia in childrenQihong Chen0Qihong Chen1Lihua Lin2Lihua Lin3Ning Zhang4Ning Zhang5Yungang Yang6Yungang Yang7Department of Pediatrics, The First Affiliated Hospital of Xiamen University, Xiamen, ChinaPediatric Key Laboratory of Xiamen, Xiamen, ChinaDepartment of Pediatrics, The First Affiliated Hospital of Xiamen University, Xiamen, ChinaPediatric Key Laboratory of Xiamen, Xiamen, ChinaDepartment of Pediatrics, The First Affiliated Hospital of Xiamen University, Xiamen, ChinaPediatric Key Laboratory of Xiamen, Xiamen, ChinaDepartment of Pediatrics, The First Affiliated Hospital of Xiamen University, Xiamen, ChinaPediatric Key Laboratory of Xiamen, Xiamen, ChinaBackgroundTo investigate the pathogenic characteristics and risk factors of pediatric severe community-acquired pneumonia (CAP).MethodsWe retrospectively analyzed the clinical data of hospitalized children with severe CAP from April 2014 to June 2019 in China. Data of age, sex and pathogenic results were collected: bacterial and fungal cultures, respiratory viruses from sputum or bronchoalveolar lavage fluid (BALF), serum Mycoplasma pneumoniae (MP)-IgM and Chlamydia Pneumoniae-IgM, and BALF or blood (1-3)-β-D-glucan/galactomannan test.ResultsA total of 679 children with severe CAP were included in the analysis. The number of cases infected with MP was higher in males than in females. There were significant differences between the ≤1-year and >1-year groups in terms of pathogen. The top three bacteria cultured were Haemophilus influenzae (57/679, 8.4%), Streptococcus pneumoniae (50/679, 7.4%), and Pseudomonas aeruginosa (25/679, 3.7%). The top three viruses detected were adenovirus (AdV, 124/679, 18.3%), respiratory syncytial virus (24/679, 3.5%), and parainfluenza virus (21/679, 3.1%). AdV and MP were the leading pathogens, detected in 18.3% and 32.6% cases, respectively. MP infection increased the risk of AdV infection (OR 3.77, p < 0.0001). MP infection was a risk factor for severe AdV-infected pneumonia, while sex, age, bacteria, Chlamydia Pneumoniae, fungal, and AdV infections were risk factors for severe MP-infected pneumonia.ConclusionsAdV and MP were dominant pathogens in children with severe CAP. AdV and MP infection predisposed each other to develop severe illness. AdV-MP co-infection may lead to severe pneumonia.https://www.frontiersin.org/articles/10.3389/fped.2024.1337786/fullcommunity-acquired pneumoniaetiologyadenovirusMycoplasma pneumoniaerisk factorchildren |
| spellingShingle | Qihong Chen Qihong Chen Lihua Lin Lihua Lin Ning Zhang Ning Zhang Yungang Yang Yungang Yang Adenovirus and Mycoplasma pneumoniae co-infection as a risk factor for severe community-acquired pneumonia in children Frontiers in Pediatrics community-acquired pneumonia etiology adenovirus Mycoplasma pneumoniae risk factor children |
| title | Adenovirus and Mycoplasma pneumoniae co-infection as a risk factor for severe community-acquired pneumonia in children |
| title_full | Adenovirus and Mycoplasma pneumoniae co-infection as a risk factor for severe community-acquired pneumonia in children |
| title_fullStr | Adenovirus and Mycoplasma pneumoniae co-infection as a risk factor for severe community-acquired pneumonia in children |
| title_full_unstemmed | Adenovirus and Mycoplasma pneumoniae co-infection as a risk factor for severe community-acquired pneumonia in children |
| title_short | Adenovirus and Mycoplasma pneumoniae co-infection as a risk factor for severe community-acquired pneumonia in children |
| title_sort | adenovirus and mycoplasma pneumoniae co infection as a risk factor for severe community acquired pneumonia in children |
| topic | community-acquired pneumonia etiology adenovirus Mycoplasma pneumoniae risk factor children |
| url | https://www.frontiersin.org/articles/10.3389/fped.2024.1337786/full |
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