In vivo imaging of hierarchical spatiotemporal activation of caspase-8 during apoptosis.

In vivo imaging of hierarchical spatiotemporal activation of caspase-8 during apoptosis.

BACKGROUND: Activation of caspases is crucial for the execution of apoptosis. Although the caspase cascade associated with activation of the initiator caspase-8 (CASP8) has been investigated in molecular and biochemical detail, the dynamics of CASP8 activation are not fully understood. METHODOLOGY/P...

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Main Authors: Katsuya Kominami, Takeharu Nagai, Tatsuya Sawasaki, Yuki Tsujimura, Kenta Yashima, Yasuhiro Sunaga, Masateru Tsuchimochi, Jun Nishimura, Kumiko Chiba, Jun Nakabayashi, Koji Koyamada, Yaeta Endo, Hideo Yokota, Atsushi Miyawaki, Noboru Manabe, Kazuhiro Sakamaki
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3503975?pdf=render

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