Repurposing the Strontium Ranelate Antiosteoporotic Drug as a New Outstanding Biocompatible Blue Dye
Blue dyes are relatively uncommon in nature, and a novel dithiophene dye (RanB) is reported in this paper. This dye is derived from an old anti-osteoporotic drug and is a metal ion complexing agent, displaying a planar molecular structure, with two sets of carboxylate, isonitrile, thiophene, and imi...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-09-01
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| Series: | Colorants |
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| Online Access: | https://www.mdpi.com/2079-6447/2/3/29 |
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| author | Luca M. Sihn Erick L. Bastos Marcelo Nakamura Mayara K. Uchiyama Henrique E. Toma |
| author_facet | Luca M. Sihn Erick L. Bastos Marcelo Nakamura Mayara K. Uchiyama Henrique E. Toma |
| author_sort | Luca M. Sihn |
| collection | DOAJ |
| description | Blue dyes are relatively uncommon in nature, and a novel dithiophene dye (RanB) is reported in this paper. This dye is derived from an old anti-osteoporotic drug and is a metal ion complexing agent, displaying a planar molecular structure, with two sets of carboxylate, isonitrile, thiophene, and iminodiacetate groups. The blue color originates from a strong absorption peak at 648 nm, accompanied by an unusual fluorescence at 555 nm, with higher energy compared to the main absorption band. RanB forms complexes with lanthanoid ions through the iminodiacetate groups and serves as an effective sensitizer for Tb<sup>3+</sup> ions, heightening their emission and improving their use as luminescent agents. Its photo-physical properties and the interaction with Tb<sup>3+</sup> have been investigated using absorption spectroscopy, steady-state and time-resolved fluorescence spectroscopy, along with computational methods (ZINDO/S and DFT). The RanB toxicity in human umbilical vein endothelial cells has also been tested, showing a lack of toxicity, holding promising prospects for application as a luminescent and coloring agent in pharmaceuticals and food. |
| first_indexed | 2024-03-10T22:54:16Z |
| format | Article |
| id | doaj.art-7830cc46c9344e288eb70f302c565459 |
| institution | Directory Open Access Journal |
| issn | 2079-6447 |
| language | English |
| last_indexed | 2024-03-10T22:54:16Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Colorants |
| spelling | doaj.art-7830cc46c9344e288eb70f302c5654592023-11-19T10:06:47ZengMDPI AGColorants2079-64472023-09-012357859010.3390/colorants2030029Repurposing the Strontium Ranelate Antiosteoporotic Drug as a New Outstanding Biocompatible Blue DyeLuca M. Sihn0Erick L. Bastos1Marcelo Nakamura2Mayara K. Uchiyama3Henrique E. Toma4Instituto de Química, Universidade de São Paulo, São Paulo 05508-000, BrazilInstituto de Química, Universidade de São Paulo, São Paulo 05508-000, BrazilInstituto de Química, Universidade de São Paulo, São Paulo 05508-000, BrazilInstituto de Química, Universidade de São Paulo, São Paulo 05508-000, BrazilInstituto de Química, Universidade de São Paulo, São Paulo 05508-000, BrazilBlue dyes are relatively uncommon in nature, and a novel dithiophene dye (RanB) is reported in this paper. This dye is derived from an old anti-osteoporotic drug and is a metal ion complexing agent, displaying a planar molecular structure, with two sets of carboxylate, isonitrile, thiophene, and iminodiacetate groups. The blue color originates from a strong absorption peak at 648 nm, accompanied by an unusual fluorescence at 555 nm, with higher energy compared to the main absorption band. RanB forms complexes with lanthanoid ions through the iminodiacetate groups and serves as an effective sensitizer for Tb<sup>3+</sup> ions, heightening their emission and improving their use as luminescent agents. Its photo-physical properties and the interaction with Tb<sup>3+</sup> have been investigated using absorption spectroscopy, steady-state and time-resolved fluorescence spectroscopy, along with computational methods (ZINDO/S and DFT). The RanB toxicity in human umbilical vein endothelial cells has also been tested, showing a lack of toxicity, holding promising prospects for application as a luminescent and coloring agent in pharmaceuticals and food.https://www.mdpi.com/2079-6447/2/3/29ranelate bluedithiophene dyeterbium luminescencebiocompatible dyefluorescent dye |
| spellingShingle | Luca M. Sihn Erick L. Bastos Marcelo Nakamura Mayara K. Uchiyama Henrique E. Toma Repurposing the Strontium Ranelate Antiosteoporotic Drug as a New Outstanding Biocompatible Blue Dye Colorants ranelate blue dithiophene dye terbium luminescence biocompatible dye fluorescent dye |
| title | Repurposing the Strontium Ranelate Antiosteoporotic Drug as a New Outstanding Biocompatible Blue Dye |
| title_full | Repurposing the Strontium Ranelate Antiosteoporotic Drug as a New Outstanding Biocompatible Blue Dye |
| title_fullStr | Repurposing the Strontium Ranelate Antiosteoporotic Drug as a New Outstanding Biocompatible Blue Dye |
| title_full_unstemmed | Repurposing the Strontium Ranelate Antiosteoporotic Drug as a New Outstanding Biocompatible Blue Dye |
| title_short | Repurposing the Strontium Ranelate Antiosteoporotic Drug as a New Outstanding Biocompatible Blue Dye |
| title_sort | repurposing the strontium ranelate antiosteoporotic drug as a new outstanding biocompatible blue dye |
| topic | ranelate blue dithiophene dye terbium luminescence biocompatible dye fluorescent dye |
| url | https://www.mdpi.com/2079-6447/2/3/29 |
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