Temporary Rise in Blood Thrombogenicity in Patients with Acute Myocardial Infarction
Objective Although blood thrombogenicity seems to be one of the determinant factors for the development of acute myocardial infarction (MI), it has not been dealt with in-depth. This study aimed to investigate blood thrombogenicity and its change in acute MI patients. Methods and Results ...
| Main Authors: | , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Georg Thieme Verlag KG
2022-01-01
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| Series: | TH Open |
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| Online Access: | http://www.thieme-connect.de/DOI/DOI?10.1055/a-1719-6178 |
| _version_ | 1811167050499883008 |
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| author | Shumpei Kosugi Yasunori Ueda Haruhiko Abe Kuniyasu Ikeoka Tsuyoshi Mishima Tatsuhisa Ozaki Kohtaro Takayasu Takuya Ohashi Haruya Yamane Masayuki Nakamura Takashi Fukushima Kohei Horiuchi Takashi Iehara Satoshi Osaki Kazuki Ozato Koichi Inoue Yukihiro Koretsune Yasushi Matsumura |
| author_facet | Shumpei Kosugi Yasunori Ueda Haruhiko Abe Kuniyasu Ikeoka Tsuyoshi Mishima Tatsuhisa Ozaki Kohtaro Takayasu Takuya Ohashi Haruya Yamane Masayuki Nakamura Takashi Fukushima Kohei Horiuchi Takashi Iehara Satoshi Osaki Kazuki Ozato Koichi Inoue Yukihiro Koretsune Yasushi Matsumura |
| author_sort | Shumpei Kosugi |
| collection | DOAJ |
| description | Objective Although blood thrombogenicity seems to be one of the determinant factors for the development of acute myocardial infarction (MI), it has not been dealt with in-depth. This study aimed to investigate blood thrombogenicity and its change in acute MI patients.
Methods and Results We designed a prospective, observational study that included 51 acute MI patients and 83 stable coronary artery disease (CAD) patients who underwent cardiac catheterization, comparing thrombogenicity of the whole blood between: (1) acute MI patients and stable CAD patients; and (2) acute and chronic phase in MI patients. Blood thrombogenicity was evaluated by the Total Thrombus-Formation Analysis System (T-TAS) using the area under the flow pressure curve (AUC30) for the AR-chip. Acute MI patients had significantly higher AUC30 than stable CAD patients (median [interquartile range], 1,771 [1,585–1,884] vs. 1,677 [1,527–1,756], p = 0.010). Multivariate regression analysis identified acute MI with initial TIMI flow grade 0/1 as an independent determinant of high AUC30 (β = 0.211, p = 0.013). In acute MI patients, AUC30 decreased significantly from acute to chronic phase (1,859 [1,550–2,008] to 1,521 [1,328–1,745], p = 0.001).
Conclusion Blood thrombogenicity was significantly higher in acute MI patients than in stable CAD patients. Acute MI with initial TIMI flow grade 0/1 was significantly associated with high blood thrombogenicity by multivariate analysis. In acute MI patients, blood thrombogenicity was temporarily higher in acute phase than in chronic phase. |
| first_indexed | 2024-04-10T16:03:45Z |
| format | Article |
| id | doaj.art-7831411ed9044d1d9ed47927d0b78e51 |
| institution | Directory Open Access Journal |
| issn | 2512-9465 |
| language | English |
| last_indexed | 2024-04-10T16:03:45Z |
| publishDate | 2022-01-01 |
| publisher | Georg Thieme Verlag KG |
| record_format | Article |
| series | TH Open |
| spelling | doaj.art-7831411ed9044d1d9ed47927d0b78e512023-02-10T09:10:07ZengGeorg Thieme Verlag KGTH Open2512-94652022-01-010601e26e3210.1055/a-1719-6178Temporary Rise in Blood Thrombogenicity in Patients with Acute Myocardial InfarctionShumpei Kosugi0Yasunori Ueda1Haruhiko Abe2Kuniyasu Ikeoka3Tsuyoshi Mishima4Tatsuhisa Ozaki5Kohtaro Takayasu6Takuya Ohashi7Haruya Yamane8Masayuki Nakamura9Takashi Fukushima10Kohei Horiuchi11Takashi Iehara12Satoshi Osaki13Kazuki Ozato14Koichi Inoue15Yukihiro Koretsune16Yasushi Matsumura17Cardiovascular Division, National Hospital Organization Osaka National Hospital, Osaka, JapanCardiovascular Division, National Hospital Organization Osaka National Hospital, Osaka, JapanCardiovascular Division, National Hospital Organization Osaka National Hospital, Osaka, JapanCardiovascular Division, National Hospital Organization Osaka National Hospital, Osaka, JapanCardiovascular Division, National Hospital Organization Osaka National Hospital, Osaka, JapanCardiovascular Division, National Hospital Organization Osaka National Hospital, Osaka, JapanCardiovascular Division, National Hospital Organization Osaka National Hospital, Osaka, JapanCardiovascular Division, National Hospital Organization Osaka National Hospital, Osaka, JapanCardiovascular Division, National Hospital Organization Osaka National Hospital, Osaka, JapanCardiovascular Division, National Hospital Organization Osaka National Hospital, Osaka, JapanCardiovascular Division, National Hospital Organization Osaka National Hospital, Osaka, JapanCardiovascular Division, National Hospital Organization Osaka National Hospital, Osaka, JapanCardiovascular Division, National Hospital Organization Osaka National Hospital, Osaka, JapanCardiovascular Division, National Hospital Organization Osaka National Hospital, Osaka, JapanCardiovascular Division, National Hospital Organization Osaka National Hospital, Osaka, JapanCardiovascular Division, National Hospital Organization Osaka National Hospital, Osaka, JapanCardiovascular Division, National Hospital Organization Osaka National Hospital, Osaka, JapanCardiovascular Division, National Hospital Organization Osaka National Hospital, Osaka, JapanObjective Although blood thrombogenicity seems to be one of the determinant factors for the development of acute myocardial infarction (MI), it has not been dealt with in-depth. This study aimed to investigate blood thrombogenicity and its change in acute MI patients. Methods and Results We designed a prospective, observational study that included 51 acute MI patients and 83 stable coronary artery disease (CAD) patients who underwent cardiac catheterization, comparing thrombogenicity of the whole blood between: (1) acute MI patients and stable CAD patients; and (2) acute and chronic phase in MI patients. Blood thrombogenicity was evaluated by the Total Thrombus-Formation Analysis System (T-TAS) using the area under the flow pressure curve (AUC30) for the AR-chip. Acute MI patients had significantly higher AUC30 than stable CAD patients (median [interquartile range], 1,771 [1,585–1,884] vs. 1,677 [1,527–1,756], p = 0.010). Multivariate regression analysis identified acute MI with initial TIMI flow grade 0/1 as an independent determinant of high AUC30 (β = 0.211, p = 0.013). In acute MI patients, AUC30 decreased significantly from acute to chronic phase (1,859 [1,550–2,008] to 1,521 [1,328–1,745], p = 0.001). Conclusion Blood thrombogenicity was significantly higher in acute MI patients than in stable CAD patients. Acute MI with initial TIMI flow grade 0/1 was significantly associated with high blood thrombogenicity by multivariate analysis. In acute MI patients, blood thrombogenicity was temporarily higher in acute phase than in chronic phase.http://www.thieme-connect.de/DOI/DOI?10.1055/a-1719-6178blood thrombogenicityacute myocardial infarctioncoronary artery diseaset-tas |
| spellingShingle | Shumpei Kosugi Yasunori Ueda Haruhiko Abe Kuniyasu Ikeoka Tsuyoshi Mishima Tatsuhisa Ozaki Kohtaro Takayasu Takuya Ohashi Haruya Yamane Masayuki Nakamura Takashi Fukushima Kohei Horiuchi Takashi Iehara Satoshi Osaki Kazuki Ozato Koichi Inoue Yukihiro Koretsune Yasushi Matsumura Temporary Rise in Blood Thrombogenicity in Patients with Acute Myocardial Infarction TH Open blood thrombogenicity acute myocardial infarction coronary artery disease t-tas |
| title | Temporary Rise in Blood Thrombogenicity in Patients with Acute Myocardial Infarction |
| title_full | Temporary Rise in Blood Thrombogenicity in Patients with Acute Myocardial Infarction |
| title_fullStr | Temporary Rise in Blood Thrombogenicity in Patients with Acute Myocardial Infarction |
| title_full_unstemmed | Temporary Rise in Blood Thrombogenicity in Patients with Acute Myocardial Infarction |
| title_short | Temporary Rise in Blood Thrombogenicity in Patients with Acute Myocardial Infarction |
| title_sort | temporary rise in blood thrombogenicity in patients with acute myocardial infarction |
| topic | blood thrombogenicity acute myocardial infarction coronary artery disease t-tas |
| url | http://www.thieme-connect.de/DOI/DOI?10.1055/a-1719-6178 |
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