Single Fasting Plasma Glucose Versus 75-g Oral Glucose-Tolerance Test in Prediction of Adverse Perinatal Outcomes: A Cohort Study
Background: There remains uncertainty regarding whether a single fasting glucose measurement is sufficient to predict risk of adverse perinatal outcomes. Methods: We included 12,594 pregnant women who underwent a 75-g oral glucose-tolerance test (OGTT) at 22–28 weeks' gestation in the Born in G...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2017-02-01
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| Series: | EBioMedicine |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352396417300294 |
| _version_ | 1811274578367873024 |
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| author | Songying Shen Jinhua Lu Lifang Zhang Jianrong He Weidong Li Niannian Chen Xingxuan Wen Wanqing Xiao Mingyang Yuan Lan Qiu Kar Keung Cheng Huimin Xia Ben Willem J. Mol Xiu Qiu |
| author_facet | Songying Shen Jinhua Lu Lifang Zhang Jianrong He Weidong Li Niannian Chen Xingxuan Wen Wanqing Xiao Mingyang Yuan Lan Qiu Kar Keung Cheng Huimin Xia Ben Willem J. Mol Xiu Qiu |
| author_sort | Songying Shen |
| collection | DOAJ |
| description | Background: There remains uncertainty regarding whether a single fasting glucose measurement is sufficient to predict risk of adverse perinatal outcomes.
Methods: We included 12,594 pregnant women who underwent a 75-g oral glucose-tolerance test (OGTT) at 22–28 weeks' gestation in the Born in Guangzhou Cohort Study, China. Outcomes were large for gestational age (LGA) baby, cesarean section, and spontaneous preterm birth. We calculated the area under the receiver operator characteristic curves (AUCs) to assess the capacity of OGTT glucose values to predict adverse outcomes, and compared the AUCs of different components of OGTT.
Results: 1325 women had a LGA baby (10.5%). Glucose measurements were linearly associated with LGA, with strongest associations for fasting glucose (odds ratio 1.37, 95% confidence interval 1.30–1.45). Weaker associations were observed for cesarean section and spontaneous preterm birth. Fasting glucose have a comparable discriminative power for prediction of LGA to the combination of fasting, 1 h, and 2 h glucose values during OGTT (AUCs, 0.611 vs. 0.614, P = 0.166). The LGA risk was consistently increased in women with abnormal fasting glucose (≥5.1 mmol/l), irrespective of 1 h or 2 h glucose levels.
Conclusions: A single fasting glucose measurement performs comparably to 75-g OGTT in predicting risk of having a LGA baby. |
| first_indexed | 2024-04-12T23:21:25Z |
| format | Article |
| id | doaj.art-783158a832014ce4a3a07412a393cbf4 |
| institution | Directory Open Access Journal |
| issn | 2352-3964 |
| language | English |
| last_indexed | 2024-04-12T23:21:25Z |
| publishDate | 2017-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | EBioMedicine |
| spelling | doaj.art-783158a832014ce4a3a07412a393cbf42022-12-22T03:12:30ZengElsevierEBioMedicine2352-39642017-02-0116C28429110.1016/j.ebiom.2017.01.025Single Fasting Plasma Glucose Versus 75-g Oral Glucose-Tolerance Test in Prediction of Adverse Perinatal Outcomes: A Cohort StudySongying Shen0Jinhua Lu1Lifang Zhang2Jianrong He3Weidong Li4Niannian Chen5Xingxuan Wen6Wanqing Xiao7Mingyang Yuan8Lan Qiu9Kar Keung Cheng10Huimin Xia11Ben Willem J. Mol12Xiu Qiu13Division of Birth Cohort Study, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, ChinaDivision of Birth Cohort Study, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, ChinaDivision of Birth Cohort Study, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, ChinaDivision of Birth Cohort Study, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, ChinaDivision of Birth Cohort Study, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, ChinaDivision of Birth Cohort Study, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, ChinaDivision of Birth Cohort Study, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, ChinaDivision of Birth Cohort Study, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, ChinaDivision of Birth Cohort Study, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, ChinaDivision of Birth Cohort Study, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, ChinaInstitute of Applied Health Research, University of Birmingham, Birmingham, UKDivision of Birth Cohort Study, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, ChinaThe Robinson Research Institute, School of Paediatrics and Reproductive Health, University of Adelaide, Adelaide, SA, AustraliaDivision of Birth Cohort Study, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, ChinaBackground: There remains uncertainty regarding whether a single fasting glucose measurement is sufficient to predict risk of adverse perinatal outcomes. Methods: We included 12,594 pregnant women who underwent a 75-g oral glucose-tolerance test (OGTT) at 22–28 weeks' gestation in the Born in Guangzhou Cohort Study, China. Outcomes were large for gestational age (LGA) baby, cesarean section, and spontaneous preterm birth. We calculated the area under the receiver operator characteristic curves (AUCs) to assess the capacity of OGTT glucose values to predict adverse outcomes, and compared the AUCs of different components of OGTT. Results: 1325 women had a LGA baby (10.5%). Glucose measurements were linearly associated with LGA, with strongest associations for fasting glucose (odds ratio 1.37, 95% confidence interval 1.30–1.45). Weaker associations were observed for cesarean section and spontaneous preterm birth. Fasting glucose have a comparable discriminative power for prediction of LGA to the combination of fasting, 1 h, and 2 h glucose values during OGTT (AUCs, 0.611 vs. 0.614, P = 0.166). The LGA risk was consistently increased in women with abnormal fasting glucose (≥5.1 mmol/l), irrespective of 1 h or 2 h glucose levels. Conclusions: A single fasting glucose measurement performs comparably to 75-g OGTT in predicting risk of having a LGA baby.http://www.sciencedirect.com/science/article/pii/S2352396417300294Fasting plasma glucoseOral glucose-tolerance testLarge for gestational ageCesarean sectionSpontaneous preterm birth |
| spellingShingle | Songying Shen Jinhua Lu Lifang Zhang Jianrong He Weidong Li Niannian Chen Xingxuan Wen Wanqing Xiao Mingyang Yuan Lan Qiu Kar Keung Cheng Huimin Xia Ben Willem J. Mol Xiu Qiu Single Fasting Plasma Glucose Versus 75-g Oral Glucose-Tolerance Test in Prediction of Adverse Perinatal Outcomes: A Cohort Study EBioMedicine Fasting plasma glucose Oral glucose-tolerance test Large for gestational age Cesarean section Spontaneous preterm birth |
| title | Single Fasting Plasma Glucose Versus 75-g Oral Glucose-Tolerance Test in Prediction of Adverse Perinatal Outcomes: A Cohort Study |
| title_full | Single Fasting Plasma Glucose Versus 75-g Oral Glucose-Tolerance Test in Prediction of Adverse Perinatal Outcomes: A Cohort Study |
| title_fullStr | Single Fasting Plasma Glucose Versus 75-g Oral Glucose-Tolerance Test in Prediction of Adverse Perinatal Outcomes: A Cohort Study |
| title_full_unstemmed | Single Fasting Plasma Glucose Versus 75-g Oral Glucose-Tolerance Test in Prediction of Adverse Perinatal Outcomes: A Cohort Study |
| title_short | Single Fasting Plasma Glucose Versus 75-g Oral Glucose-Tolerance Test in Prediction of Adverse Perinatal Outcomes: A Cohort Study |
| title_sort | single fasting plasma glucose versus 75 g oral glucose tolerance test in prediction of adverse perinatal outcomes a cohort study |
| topic | Fasting plasma glucose Oral glucose-tolerance test Large for gestational age Cesarean section Spontaneous preterm birth |
| url | http://www.sciencedirect.com/science/article/pii/S2352396417300294 |
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