Adiponectin Attenuates Lipopolysaccharide-induced Apoptosis by Regulating the Cx43/PI3K/AKT Pathway

Adiponectin Attenuates Lipopolysaccharide-induced Apoptosis by Regulating the Cx43/PI3K/AKT Pathway

Cardiomyocyte apoptosis is a crucial factor leading to myocardial dysfunction. Adiponectin (APN) has a cardiomyocyte-protective impact. Studies have shown that the connexin43 (Cx43) and phosphatidylinositol-3-kinase (PI3K)/protein kinase B (AKT) signaling pathways play an important role in the heart...

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Bibliographic Details
Main Authors: Luqian Liu, Meijuan Yan, Rui Yang, Xuqing Qin, Ling Chen, Li Li, Junqiang Si, Xinzhi Li, Ketao Ma
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Pharmacology
Subjects:
adiponectin
apoptosis
sepsis
PI3K/AKT
connexin43
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.644225/full

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