DNA methylation landscapes of 1538 breast cancers reveal a replication-linked clock, epigenomic instability and cis-regulation
Understanding the molecular mechanisms underlying DNA methylation in cancer and its clinical relevance remains crucial. Here, the authors study RRBS-based profiles of 1538 breast tumours and 244 normal breast tissues from the METABRIC cohort and report epigenomic instability and cis-regulatory effec...
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Bibliographic Details
| Main Authors: |
Rajbir Nath Batra,
Aviezer Lifshitz,
Ana Tufegdzic Vidakovic,
Suet-Feung Chin,
Ankita Sati-Batra,
Stephen-John Sammut,
Elena Provenzano,
H. Raza Ali,
Ali Dariush,
Alejandra Bruna,
Leigh Murphy,
Arnie Purushotham,
Ian Ellis,
Andrew Green,
Francine E. Garrett-Bakelman,
Chris Mason,
Ari Melnick,
Samuel A. J. R. Aparicio,
Oscar M. Rueda,
Amos Tanay,
Carlos Caldas |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Portfolio
2021-09-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-021-25661-w
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