DNA methylation landscapes of 1538 breast cancers reveal a replication-linked clock, epigenomic instability and cis-regulation
Understanding the molecular mechanisms underlying DNA methylation in cancer and its clinical relevance remains crucial. Here, the authors study RRBS-based profiles of 1538 breast tumours and 244 normal breast tissues from the METABRIC cohort and report epigenomic instability and cis-regulatory effec...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-09-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-25661-w |
| _version_ | 1818460303953756160 |
|---|---|
| author | Rajbir Nath Batra Aviezer Lifshitz Ana Tufegdzic Vidakovic Suet-Feung Chin Ankita Sati-Batra Stephen-John Sammut Elena Provenzano H. Raza Ali Ali Dariush Alejandra Bruna Leigh Murphy Arnie Purushotham Ian Ellis Andrew Green Francine E. Garrett-Bakelman Chris Mason Ari Melnick Samuel A. J. R. Aparicio Oscar M. Rueda Amos Tanay Carlos Caldas |
| author_facet | Rajbir Nath Batra Aviezer Lifshitz Ana Tufegdzic Vidakovic Suet-Feung Chin Ankita Sati-Batra Stephen-John Sammut Elena Provenzano H. Raza Ali Ali Dariush Alejandra Bruna Leigh Murphy Arnie Purushotham Ian Ellis Andrew Green Francine E. Garrett-Bakelman Chris Mason Ari Melnick Samuel A. J. R. Aparicio Oscar M. Rueda Amos Tanay Carlos Caldas |
| author_sort | Rajbir Nath Batra |
| collection | DOAJ |
| description | Understanding the molecular mechanisms underlying DNA methylation in cancer and its clinical relevance remains crucial. Here, the authors study RRBS-based profiles of 1538 breast tumours and 244 normal breast tissues from the METABRIC cohort and report epigenomic instability and cis-regulatory effects. |
| first_indexed | 2024-12-14T23:28:07Z |
| format | Article |
| id | doaj.art-7832b4cd7ff242839e4e5e73265c879e |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-14T23:28:07Z |
| publishDate | 2021-09-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-7832b4cd7ff242839e4e5e73265c879e2022-12-21T22:43:45ZengNature PortfolioNature Communications2041-17232021-09-0112111310.1038/s41467-021-25661-wDNA methylation landscapes of 1538 breast cancers reveal a replication-linked clock, epigenomic instability and cis-regulationRajbir Nath Batra0Aviezer Lifshitz1Ana Tufegdzic Vidakovic2Suet-Feung Chin3Ankita Sati-Batra4Stephen-John Sammut5Elena Provenzano6H. Raza Ali7Ali Dariush8Alejandra Bruna9Leigh Murphy10Arnie Purushotham11Ian Ellis12Andrew Green13Francine E. Garrett-Bakelman14Chris Mason15Ari Melnick16Samuel A. J. R. Aparicio17Oscar M. Rueda18Amos Tanay19Carlos Caldas20Cancer Research UK Cambridge Institute, Li Ka Shing Centre, University of CambridgeDepartment of Computer Science and Applied Mathematics, and Department of Biological Regulation, Weizmann Institute of ScienceMechanisms of Transcription Laboratory, The Francis Crick InstituteCancer Research UK Cambridge Institute, Li Ka Shing Centre, University of CambridgeCancer Research UK Cambridge Institute, Li Ka Shing Centre, University of CambridgeCancer Research UK Cambridge Institute, Li Ka Shing Centre, University of CambridgeCancer Research UK Cambridge CentreCancer Research UK Cambridge Institute, Li Ka Shing Centre, University of CambridgeCancer Research UK Cambridge Institute, Li Ka Shing Centre, University of CambridgeCancer Research UK Cambridge Institute, Li Ka Shing Centre, University of CambridgeResearch Institute in Oncology and HematologySchool of Cancer and Pharmaceutical Sciences, King’s College LondonDivision of Cancer and Stem Cells, School of Medicine, University of Nottingham and Nottingham University Hospital NHS TrustDivision of Cancer and Stem Cells, School of Medicine, University of Nottingham and Nottingham University Hospital NHS TrustDivision of Hematology and Medical Oncology, Weill Cornell MedicineDepartment of Physiology and Biophysics, Weill Cornell MedicineDivision of Hematology and Medical Oncology, Weill Cornell MedicineDepartment of Molecular Oncology, British Columbia Cancer Research CentreCancer Research UK Cambridge Institute, Li Ka Shing Centre, University of CambridgeDepartment of Computer Science and Applied Mathematics, and Department of Biological Regulation, Weizmann Institute of ScienceCancer Research UK Cambridge Institute, Li Ka Shing Centre, University of CambridgeUnderstanding the molecular mechanisms underlying DNA methylation in cancer and its clinical relevance remains crucial. Here, the authors study RRBS-based profiles of 1538 breast tumours and 244 normal breast tissues from the METABRIC cohort and report epigenomic instability and cis-regulatory effects.https://doi.org/10.1038/s41467-021-25661-w |
| spellingShingle | Rajbir Nath Batra Aviezer Lifshitz Ana Tufegdzic Vidakovic Suet-Feung Chin Ankita Sati-Batra Stephen-John Sammut Elena Provenzano H. Raza Ali Ali Dariush Alejandra Bruna Leigh Murphy Arnie Purushotham Ian Ellis Andrew Green Francine E. Garrett-Bakelman Chris Mason Ari Melnick Samuel A. J. R. Aparicio Oscar M. Rueda Amos Tanay Carlos Caldas DNA methylation landscapes of 1538 breast cancers reveal a replication-linked clock, epigenomic instability and cis-regulation Nature Communications |
| title | DNA methylation landscapes of 1538 breast cancers reveal a replication-linked clock, epigenomic instability and cis-regulation |
| title_full | DNA methylation landscapes of 1538 breast cancers reveal a replication-linked clock, epigenomic instability and cis-regulation |
| title_fullStr | DNA methylation landscapes of 1538 breast cancers reveal a replication-linked clock, epigenomic instability and cis-regulation |
| title_full_unstemmed | DNA methylation landscapes of 1538 breast cancers reveal a replication-linked clock, epigenomic instability and cis-regulation |
| title_short | DNA methylation landscapes of 1538 breast cancers reveal a replication-linked clock, epigenomic instability and cis-regulation |
| title_sort | dna methylation landscapes of 1538 breast cancers reveal a replication linked clock epigenomic instability and cis regulation |
| url | https://doi.org/10.1038/s41467-021-25661-w |
| work_keys_str_mv | AT rajbirnathbatra dnamethylationlandscapesof1538breastcancersrevealareplicationlinkedclockepigenomicinstabilityandcisregulation AT aviezerlifshitz dnamethylationlandscapesof1538breastcancersrevealareplicationlinkedclockepigenomicinstabilityandcisregulation AT anatufegdzicvidakovic dnamethylationlandscapesof1538breastcancersrevealareplicationlinkedclockepigenomicinstabilityandcisregulation AT suetfeungchin dnamethylationlandscapesof1538breastcancersrevealareplicationlinkedclockepigenomicinstabilityandcisregulation AT ankitasatibatra dnamethylationlandscapesof1538breastcancersrevealareplicationlinkedclockepigenomicinstabilityandcisregulation AT stephenjohnsammut dnamethylationlandscapesof1538breastcancersrevealareplicationlinkedclockepigenomicinstabilityandcisregulation AT elenaprovenzano dnamethylationlandscapesof1538breastcancersrevealareplicationlinkedclockepigenomicinstabilityandcisregulation AT hrazaali dnamethylationlandscapesof1538breastcancersrevealareplicationlinkedclockepigenomicinstabilityandcisregulation AT alidariush dnamethylationlandscapesof1538breastcancersrevealareplicationlinkedclockepigenomicinstabilityandcisregulation AT alejandrabruna dnamethylationlandscapesof1538breastcancersrevealareplicationlinkedclockepigenomicinstabilityandcisregulation AT leighmurphy dnamethylationlandscapesof1538breastcancersrevealareplicationlinkedclockepigenomicinstabilityandcisregulation AT arniepurushotham dnamethylationlandscapesof1538breastcancersrevealareplicationlinkedclockepigenomicinstabilityandcisregulation AT ianellis dnamethylationlandscapesof1538breastcancersrevealareplicationlinkedclockepigenomicinstabilityandcisregulation AT andrewgreen dnamethylationlandscapesof1538breastcancersrevealareplicationlinkedclockepigenomicinstabilityandcisregulation AT francineegarrettbakelman dnamethylationlandscapesof1538breastcancersrevealareplicationlinkedclockepigenomicinstabilityandcisregulation AT chrismason dnamethylationlandscapesof1538breastcancersrevealareplicationlinkedclockepigenomicinstabilityandcisregulation AT arimelnick dnamethylationlandscapesof1538breastcancersrevealareplicationlinkedclockepigenomicinstabilityandcisregulation AT samuelajraparicio dnamethylationlandscapesof1538breastcancersrevealareplicationlinkedclockepigenomicinstabilityandcisregulation AT oscarmrueda dnamethylationlandscapesof1538breastcancersrevealareplicationlinkedclockepigenomicinstabilityandcisregulation AT amostanay dnamethylationlandscapesof1538breastcancersrevealareplicationlinkedclockepigenomicinstabilityandcisregulation AT carloscaldas dnamethylationlandscapesof1538breastcancersrevealareplicationlinkedclockepigenomicinstabilityandcisregulation |