New insights into the neuroprotective and beta-secretase1 inhibitor profiles of tirandamycin B isolated from a newly found Streptomyces composti sp. nov.

New insights into the neuroprotective and beta-secretase1 inhibitor profiles of tirandamycin B isolated from a newly found Streptomyces composti sp. nov.

Abstract Tirandamycin (TAM B) is a tetramic acid antibiotic discovered to be active on a screen designed to find compounds with neuroprotective activity. The producing strain, SBST2-5T, is an actinobacterium that was isolated from wastewater treatment bio–sludge compost collected from Suphanburi pro...

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Bibliographic Details
Main Authors: Thitikorn Duangupama, Jaturong Pratuangdejkul, Sumet Chongruchiroj, Pattama Pittayakhajonwut, Chakapong Intaraudom, Sarin Tadtong, Patcharawee Nunthanavanit, Weerasak Samee, Ya-Wen He, Somboon Tanasupawat, Chitti Thawai
Format: Article
Language:English
Published: Nature Portfolio 2023-03-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-32043-3

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