Clinical Potential of YY1-Hypoxia Axis for Vascular Normalization and to Improve Immunotherapy

Clinical Potential of YY1-Hypoxia Axis for Vascular Normalization and to Improve Immunotherapy

Abnormal vasculature in solid tumors causes poor blood perfusion, hypoxia, low pH, and immune evasion. It also shapes the tumor microenvironment and affects response to immunotherapy. The combination of antiangiogenic therapy and immunotherapy has emerged as a promising approach to normalize vascula...

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Bibliographic Details
Main Authors: Concetta Meo, Filomena de Nigris
Format: Article
Language:English
Published: MDPI AG 2024-01-01
Series:Cancers
Subjects:
tumor vascularization
hypoxia
immunotherapy
Online Access:https://www.mdpi.com/2072-6694/16/3/491

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