Revisiting the Regenerative Therapeutic Advances Towards Erectile Dysfunction
Erectile dysfunction (ED) is an inability to attain or maintain adequate penile erection for successful vaginal intercourse, leading to sexual and relationship dissatisfaction. To combat ED, various surgical and non-surgical approaches have been developed in the past to restore erectile functions. T...
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MDPI AG
2020-05-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/9/5/1250 |
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| author | Ming-Che Liu Meng-Lin Chang Ya-Chun Wang Wei-Hung Chen Chien-Chih Wu Shauh-Der Yeh |
| author_facet | Ming-Che Liu Meng-Lin Chang Ya-Chun Wang Wei-Hung Chen Chien-Chih Wu Shauh-Der Yeh |
| author_sort | Ming-Che Liu |
| collection | DOAJ |
| description | Erectile dysfunction (ED) is an inability to attain or maintain adequate penile erection for successful vaginal intercourse, leading to sexual and relationship dissatisfaction. To combat ED, various surgical and non-surgical approaches have been developed in the past to restore erectile functions. These therapeutic interventions exhibit significant impact in providing relief to patients; however, due to their associated adverse effects and lack of long-term efficacy, newer modalities such as regenerative therapeutics have gained attention due to their safe and prolonged efficacy. Stem cells and platelet-derived biomaterials contained in platelet-rich plasma (PRP) are thriving as some of the major therapeutic regenerative agents. In recent years, various preclinical and clinical studies have evaluated the individual, as well as combined of stem cells and PRP to restore erectile function. Being rich in growth factors, chemokines, and angiogenic factors, both stem cells and PRP play a crucial role in regenerating nerve cells, myelination of axons, homing and migration of progenitor cells, and anti-fibrosis and anti-apoptosis of damaged cavernous nerve in corporal tissues. Further, platelet-derived biomaterials have been proven to be a biological supplement for enhancing the proliferative and differentiation potential of stem cells towards neurogenic fate. Therefore, this article comprehensively analyzes the progresses of these regenerative therapies for ED. |
| first_indexed | 2024-03-10T19:44:50Z |
| format | Article |
| id | doaj.art-78375b4e85ee4b408d2e8a38317c41aa |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T19:44:50Z |
| publishDate | 2020-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-78375b4e85ee4b408d2e8a38317c41aa2023-11-20T00:54:56ZengMDPI AGCells2073-44092020-05-0195125010.3390/cells9051250Revisiting the Regenerative Therapeutic Advances Towards Erectile DysfunctionMing-Che Liu0Meng-Lin Chang1Ya-Chun Wang2Wei-Hung Chen3Chien-Chih Wu4Shauh-Der Yeh5Department of Urology, Taipei Medical University Hospital, Taipei 11031, TaiwanDepartment of Urology, Fu Jen Catholic University Hospital, Fu Jen Catholic University, New Taipei City 242, TaiwanTCM Biotech International Corp., New Taipei City 22175, TaiwanTCM Biotech International Corp., New Taipei City 22175, TaiwanDepartment of Urology, Taipei Medical University Hospital, Taipei 11031, TaiwanDepartment of Urology and Oncology, Taipei Medical University Hospital, Taipei 11031, TaiwanErectile dysfunction (ED) is an inability to attain or maintain adequate penile erection for successful vaginal intercourse, leading to sexual and relationship dissatisfaction. To combat ED, various surgical and non-surgical approaches have been developed in the past to restore erectile functions. These therapeutic interventions exhibit significant impact in providing relief to patients; however, due to their associated adverse effects and lack of long-term efficacy, newer modalities such as regenerative therapeutics have gained attention due to their safe and prolonged efficacy. Stem cells and platelet-derived biomaterials contained in platelet-rich plasma (PRP) are thriving as some of the major therapeutic regenerative agents. In recent years, various preclinical and clinical studies have evaluated the individual, as well as combined of stem cells and PRP to restore erectile function. Being rich in growth factors, chemokines, and angiogenic factors, both stem cells and PRP play a crucial role in regenerating nerve cells, myelination of axons, homing and migration of progenitor cells, and anti-fibrosis and anti-apoptosis of damaged cavernous nerve in corporal tissues. Further, platelet-derived biomaterials have been proven to be a biological supplement for enhancing the proliferative and differentiation potential of stem cells towards neurogenic fate. Therefore, this article comprehensively analyzes the progresses of these regenerative therapies for ED.https://www.mdpi.com/2073-4409/9/5/1250erectile dysfunction (ED)platelet-rich plasma (PRP)platelet-derived biomaterialsstem cellsregenerative therapyintracavernosal injection |
| spellingShingle | Ming-Che Liu Meng-Lin Chang Ya-Chun Wang Wei-Hung Chen Chien-Chih Wu Shauh-Der Yeh Revisiting the Regenerative Therapeutic Advances Towards Erectile Dysfunction Cells erectile dysfunction (ED) platelet-rich plasma (PRP) platelet-derived biomaterials stem cells regenerative therapy intracavernosal injection |
| title | Revisiting the Regenerative Therapeutic Advances Towards Erectile Dysfunction |
| title_full | Revisiting the Regenerative Therapeutic Advances Towards Erectile Dysfunction |
| title_fullStr | Revisiting the Regenerative Therapeutic Advances Towards Erectile Dysfunction |
| title_full_unstemmed | Revisiting the Regenerative Therapeutic Advances Towards Erectile Dysfunction |
| title_short | Revisiting the Regenerative Therapeutic Advances Towards Erectile Dysfunction |
| title_sort | revisiting the regenerative therapeutic advances towards erectile dysfunction |
| topic | erectile dysfunction (ED) platelet-rich plasma (PRP) platelet-derived biomaterials stem cells regenerative therapy intracavernosal injection |
| url | https://www.mdpi.com/2073-4409/9/5/1250 |
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