Use of ornidazole in the treatment of anaerobic infection in surgery
One of the most complex problems of modern surgery is the treatment and prevention of anaerobic infection. Main place in overcoming of this infectious complication is devoted to urgent surgical intervention and correct early empiric antibacterial therapy. Special place in the combined empiric antiba...
| Main Authors: | , , |
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| Format: | Article |
| Language: | Russian |
| Published: |
Interdisciplinary Academy of Pain Medicine
2021-03-01
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| Series: | Perioperative Medicine |
| Subjects: | |
| Online Access: | https://perioperative.org.ua/index.php/prtmdc/article/view/49 |
| _version_ | 1831642877436887040 |
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| author | Yu M Babina O A Nazarchuk D V Dmytriiev |
| author_facet | Yu M Babina O A Nazarchuk D V Dmytriiev |
| author_sort | Yu M Babina |
| collection | DOAJ |
| description | One of the most complex problems of modern surgery is the treatment and prevention of anaerobic infection. Main place in overcoming of this infectious complication is devoted to urgent surgical intervention and correct early empiric antibacterial therapy. Special place in the combined empiric antibacterial treatment is devoted to 5-nitroimidazoles. Modern data about clinical efficacy of ornidazole in the treatment of surgical infectious complications is presented in the article. We performed a comparison of therapeutic activity and physical-chemical properties, pharmacokinetic and pharmacodynamic features of ornidazole with the first representative of 5-nitroimidazole class – metronidazole. Taking into account antiprotozoal and antianaerobic activity of ornidazole, it is recommended to be used in the schemes of combined therapy of severe generalized anaerobic infections and purulent processes of different localization; treatment and prevention of surgical infections after intraabdominal, thoracic, proctological and dental surgical interventions. |
| first_indexed | 2024-12-19T12:49:01Z |
| format | Article |
| id | doaj.art-7838bc7f764c47bba3a46256d49e2f50 |
| institution | Directory Open Access Journal |
| issn | 2616-339X 2617-2925 |
| language | Russian |
| last_indexed | 2024-12-19T12:49:01Z |
| publishDate | 2021-03-01 |
| publisher | Interdisciplinary Academy of Pain Medicine |
| record_format | Article |
| series | Perioperative Medicine |
| spelling | doaj.art-7838bc7f764c47bba3a46256d49e2f502022-12-21T20:20:37ZrusInterdisciplinary Academy of Pain MedicinePerioperative Medicine2616-339X2617-29252021-03-013210.31636/prmd.v3i2.3Use of ornidazole in the treatment of anaerobic infection in surgeryYu M Babina0O A Nazarchuk1D V Dmytriiev2National Pirogov Memorial Medical University, VinnytsiaNational Pirogov Memorial Medical University, VinnytsiaNational Pirogov Memorial Medical University, VinnytsiaOne of the most complex problems of modern surgery is the treatment and prevention of anaerobic infection. Main place in overcoming of this infectious complication is devoted to urgent surgical intervention and correct early empiric antibacterial therapy. Special place in the combined empiric antibacterial treatment is devoted to 5-nitroimidazoles. Modern data about clinical efficacy of ornidazole in the treatment of surgical infectious complications is presented in the article. We performed a comparison of therapeutic activity and physical-chemical properties, pharmacokinetic and pharmacodynamic features of ornidazole with the first representative of 5-nitroimidazole class – metronidazole. Taking into account antiprotozoal and antianaerobic activity of ornidazole, it is recommended to be used in the schemes of combined therapy of severe generalized anaerobic infections and purulent processes of different localization; treatment and prevention of surgical infections after intraabdominal, thoracic, proctological and dental surgical interventions.https://perioperative.org.ua/index.php/prtmdc/article/view/49non-clostridial anaerobic infectionnitro-imidazoleornidazole |
| spellingShingle | Yu M Babina O A Nazarchuk D V Dmytriiev Use of ornidazole in the treatment of anaerobic infection in surgery Perioperative Medicine non-clostridial anaerobic infection nitro-imidazole ornidazole |
| title | Use of ornidazole in the treatment of anaerobic infection in surgery |
| title_full | Use of ornidazole in the treatment of anaerobic infection in surgery |
| title_fullStr | Use of ornidazole in the treatment of anaerobic infection in surgery |
| title_full_unstemmed | Use of ornidazole in the treatment of anaerobic infection in surgery |
| title_short | Use of ornidazole in the treatment of anaerobic infection in surgery |
| title_sort | use of ornidazole in the treatment of anaerobic infection in surgery |
| topic | non-clostridial anaerobic infection nitro-imidazole ornidazole |
| url | https://perioperative.org.ua/index.php/prtmdc/article/view/49 |
| work_keys_str_mv | AT yumbabina useofornidazoleinthetreatmentofanaerobicinfectioninsurgery AT oanazarchuk useofornidazoleinthetreatmentofanaerobicinfectioninsurgery AT dvdmytriiev useofornidazoleinthetreatmentofanaerobicinfectioninsurgery |